Detailed Program

7:00 a.m. - 6:00 p.m.

Registration

Lobby
Convention Level - East

8:30 a.m. - 5:00 p.m.

Satellites
*Registration Fee Applies

Joint Satellite - Placental & Fetal Physiology

Meeting Room 1
Meeting Level - East

Endometrial Satellite

Meeting Room 8&15
Meeting Level - East

Joint Satellite - Myometrium/Parturition/PREBIC

Meeting Room 2&3
Meeting Level - East

Ovarian Biology Satellite

Meeting Room 11
Meeting Level - East

12:00 p.m. - 1:00 p.m.

Mid-Career Session
*Ticketed

Meeting Room 12
Meeting Level - East

5:15 p.m. - 6:15 p.m.

Early Career Forum
*Ticketed

Meeting Room 2&3
Meeting Level - East

6:30 p.m. - 8:00 p.m.

Welcome Reception

Ballroom BC
Convention Level - East

7:00 a.m. - 6:00 p.m.

Registration

Lobby
Convention Level - East

8:00 a.m. - 8:10 a.m.

 Presidential Welcome

Ballroom BC
Convention Level - East

8:10 a.m. - 9:00 a.m.

President's Distinguished Lecture I

Prof. Tessa Roseboom, PhD
Amsterdam UMC, University of Amsterdam
Amsterdam, Netherlands

 Laying foundation for healthy generations: lessons from the past to inform the future

Ballroom BC
Convention Level - East

9:00 a.m. - 10:00 a.m.

President's New Investigator Plenary
Supported by the Past Presidents' Fund
Moderators:
Yoel Sadovsky, MD
Kelle Moley, MD

Ballroom BC
Convention Level - East

9:00 a.m. - 9:15 a.m.

O-001: Maternal Extracellular Vesicle Derived miR-375-3p Promotes Fetal Overgrowth in Healthy Pregnant Mice
Manon D Owen, Rachel Quilang, Abigail Byford, Leander Stewart, Melanie Reay, Naima Endesh, Simon Futers, Neil Turner, Nadira Yuldasheva, Jayne Charnock, Rebecca Spencer, Niamh Forde, Beth Holder, Susan Ozanne, Eleanor M Scott, Karen Forbes

9:15 a.m. - 9:30 a.m.

O-002: Modulating an Essential Gene for Cellular Senescence in a Mouse Model of Pelvic Organ Prolapse
Mari J. Domingo, Haolin Shi, Kristin S Miller, Maria E Florian-Rodriguez

9:30 a.m. - 9:45 a.m.

O-003: In Utero Endothelial Cells Under-Express Vasculature Development Genes and Have Poor Elongation in Response to Flow in Single Ventricle Congenital Heart Disease
Angela Desmond, Anhyo Jeong, Guadalupe Martinez, Arjun Bhattacharya, Yalda Afshar

9:45 a.m. - 10:00 a.m.

O-004: Human Vaginal Stem Cells: Identification Using Cell Surface Markers and Functional Assays
Kjiana E Schwab, Srividya P Babu, Shanti Gurung,^, Anna Rosamilia, Pamela A Moalli, Kyle E Orwig, Caroline E Gargett

10:00 a.m. - 12:00 p.m.

Poster Session I

Exhibit Hall B
Convention Level - East

12:00 p.m. - 1:00 p.m.

Lunch & Learn Session
Reproductive Health Sciences: A Global Perspective
*Boxed lunches were available for purchase through online registration only.

Moderators:
Tania Ortiga-Carvalho, PhD
Genevieve Neal-Perry, MD, PhD

Pregnancy and newborn health in Africa: A research perspective
Shane Norris, PhD

AMPATH: A collaboration to improve reproductive health in Western Kenya
Rachael Spitzer, MD, MPH, FRCSC
Astrid Christoffersen-Deb, PhD, MDCM, FACOG, FRCPC

Ballroom BC
Convention Level - East

1:15 p.m. - 3:15 p.m.

Concurrent Mini-Symposia I

Interventions to Support Healthy Life Trajectories in Humans

Moderators:
Kent Thornburg, PhD
Chiara Mando, PhD

Meeting Room 11
Meeting Level - East

1:15 p.m. - 1:45 p.m.

Revolutionising maternal and newborn care in Africa: Pathways for a healthier future
Shane Norris, PhD

1:45 p.m. - 2:15 p.m.

Designing Digital Interventions to reduce Lifecourse Risk among Patients with Polycystic Ovary Syndrome (PCOS)
Shruthi Mahalingaiah, MD, MS

2:15 p.m. - 2:45 p.m.

Maternal Obesity; Consequences for Cardiac Function in the Child
Lucilla Poston CBE

2:45 p.m. - 3:15 p.m.

Maternal metabolic and mental health and offspring health and development – translation of research findings into interventions and policy.
Johan G Eriksson, MD, DMSc

Brain Health Across the Lifespan: Effects of Adverse Pregnancy

Meeting Room 8/15
Meeting Level - East

Moderators:
William Pearce, PhD
Emily Cornish, BA BMBCh DTM&H MRCOG

1:15 p.m. - 1:45 p.m.

Fetal cerebrovascular implication of fetal growth restriction
Beth Allison, PhD

1:45 p.m. - 2:15 p.m.

Therapeutic targets for perinatal brain injury
Irina Burd, MD, PhD

2:15 p.m. - 2:45 p.m.

The impact of obesity in pregnancy on offspring hypothalamic feeding pathways
Laura Dearden, PhD

2:45 p.m. - 3:15 p.m.

Maternal brain risk in adverse pregnancy
Marilyn Cipolla, PhD

Don't Forget Mum! - Adverse Pregnancy and Maternal Health Risk

1:15 p.m. - 1:45 p.m.

Interventions during obese pregnancy: opportunities to improve maternal as well as offspring health
Sue Ozanne, PhD

1:45 p.m. - 2:15 p.m.

Mechanisms for impaired cardiovascular outcomes following preeclampsia - evidence from animal studies
Floor Spaans, PhD

2:15 p.m. - 2:45 p.m.

GDM precision prevention, diagnosis, prognosis, and treatment:  The EMPOWeR trial
Rebecca Reynolds, PhD, FRCP, FRCPE

2:45 p.m. - 3:15 p.m.

Maternal cardiometabolic health following pregnancy complications in women living with socioeconomic disadvantage
Claire Roberts, PhD

Next Generation Biomaterials for Reproductive Research

Moderators:
Michelle L. Oyen, PhD
Amanda Kallen, MD

Meeting Room 1
Meeting Level - East

1:15 p.m. - 1:45 p.m.

Targeted Nanoliposome Therapy in Obstetrics and Gynecology
Roger Smith, AM, MBBS, FRACP, PhD

1:45 p.m. - 2:15 p.m.

Menstrual fluid for the study of endometrial biology
Angela Goncalves, PhD

2:15 p.m. - 2:45 p.m.

Tissue engineering the endometriotic phenotype using organoid systems
Juan Gnecco, PhD

2:45 p.m. - 3:15 p.m.

Decidua-mimicking hydrogels for the study of trophoblast invasion
Michelle L. Oyen, PhD

Environmental toxins and Uterine Fibroids

Moderators:
Ayman Al-Hendy, MD, PhD
Shannon Hawkins, MD, PHD

1:15 p.m. - 1:45 p.m.

Effects of endocrine-disrupting chemicals on female reproductive health
Richelle Duque Björvang, MD, PhD

1:45 p.m. - 2:15 p.m.

At-risk myometrial stem cells response to phthalate exposures using a novel 3D organoid model
Mohamed Ali, PhD

2:15 p.m. - 2:45 p.m.

Phthalates and leiomyoma pathogenesis: Molecular mechanisms
Serdar Bulun, MD

2:45 p.m. - 3:15 p.m.

Phthalates and uterine fibroids: A public health perspective
Ami Zota, ScD

Nanotubes in Reproduction

Moderators:
Steve Lye, PhD
Shannon Whirledge, PhD, MHS

Meeting Room 13
Meeting Level - East

1:15 p.m. - 1:45 p.m.

Introduction and State-of-the-Field of Tunneling Nanotubes (TNTs) and Related Cell Protrusions: an overview of their potential functions and implications
Emil Lou MD, PhD, FACP

1:45 p.m. - 2:15 p.m.

Cellular networking via tunneling nanotubes in ovarian cancer
Emil Lou MD, PhD, FACP

2:15 p.m. - 2:45 p.m.

Tunneling nanotubes: Macrophage-Myocyte communication and cargo transport in pregnant uterus
Lubna Nadeem, PhD

2:45 p.m. - 3:15 p.m.

Intercellular Communication in the Ovarian Follicle: Strategies and Tools
Hugh Clarke, PhD

3:15 p.m. - 3:30 p.m.

Coffee Break

3:30 p.m. - 5:30 p.m.

Concurrent Oral Presentations I

Clinical and Translational Perinatology I

Moderators:
Bo Jacobsson, MD, PhD
Jessica Garcia de Paredes, MD

Meeting Room 1
Meeting Level - East

3:30 p.m. - 3:45 p.m.

O-005: The Associations between Diet and Cardiometabolic Health After Pregnancy
McKenzie K. Jancsura, Michael D Wirth, Nathan P Helsabeck, William Grobman, nuMoM2b HHS Investigators

3:45 p.m. - 4:00 p.m.

O-006: Development of an Explainable AI Tool for Risk Stratification in Fetal Growth Restriction
Raquel Zimmerman, , Edgar Javier Hernandez, Mark Yandell, Nathan Blue

4:00 p.m. - 4:15 p.m.

O-007: Maternal Body Mass Index and Neonatal Morbidity After Labor at Term
Jennifer L Grasch, Kartik K Venkatesh, Uma M Reddy, Lynn M Yee, Robert M Silver, Hyagriv Simhan, Brian Mercer, Judith Chung, David M Haas, Becky McNeil, William A Grobman, Heather A Frey

4:15 p.m. - 4:30 p.m.

O-008: Childhood Sexual Abuse and Post Cesarean Pain
Jennifer L. Bailit

4:30 p.m. - 4:45 p.m.

O-009: Changes in Sphingolipid Content of Small Extracellular Vesicles from Gestational Diabetes Pregnancies Contribute to Maternal Endothelial Dysfunction
Tik Tsun (Ivan) Cheng, Frederik Nguyen, Isabella Caniggia

4:45 p.m. - 5:00 p.m.

O-012: Maternal Hyperinsulinemia Independently Alters Immune Cell Composition and Induces Placental Inflammation
Tracy Kabao Her, Grace Chung, Anh Nguyen, Seokwon Jo, Megan Beetch, Ernesto Bernal-Mizrachi, Emilyn Alejandro

5:00 p.m. - 5:15 p.m.

O-011: Maternal DHA Supplementation Alters Placental Phospholipid Content
Katie L Bidne, Karin A Zemski Berry, Thomas Jansson, Theresa L Powell

5:15 p.m. - 5:30 p.m.

O-010: Maternal Diet Determines Offspring Gut Serotonin Response in Primates
Gwendolynn Hummel, Erin E Bolte, Mindy Engevik, Derek O'Neil, Kjersti M Aagaard

Gynecology I

Moderators:
Ripla Arora, PhD
Maira Casalechi

3:30 p.m. - 3:45 p.m.

O-013: Using Cancer-Driver Mutations to Identify Candidate Drug Targets for Endometriosis Therapy
Daniëlle Peterse, Samuel Garrard, Dayana Alay Gonzalez, Ghalali Aram, Michael Rogers

3:45 p.m. - 4:00 p.m.

O-014: Endometriotic Epithelium Activates Inflammatory Signaling of Macrophages in Superficial Peritoneal Lesions
Gregory W Burns, Zhen Fu, Erin L Vegter, Zachary B Madaj, Erin Greaves, Idhaliz Flores, Asgerally T Fazleabas

4:00 p.m. - 4:15 p.m.

O-015:The Biophysical Microenvironment Impacts Endometrial Epithelial Tissue Invasion
Ayse Nihan Kilinc, Samantha E. Holt, Heather George, Juan Gnecco, Linda Griffith

4:15 p.m. - 4:30 p.m.

O-016: Reversal of Fibrosis with Improvement of Endometrial Receptivity of Adenomyotic Uteri by Conditioned Media of Adipose-Derived Stem Cells
Joseph Huang, Chun-Yen Huang, Yu-Hao Huang, Ya-Chun Yu, Li-Yen Shiu, Yun-Hsian Hung

4:30 p.m. - 4:45 p.m.

O-017: Therapeutic Effect of Nanoceria as a Non-Steroidal Anti-Inflammatory Drug on Endometriosis in a Mouse Model
Taeho Kim, Md Saidur Rahman, Kay Hadrick, Seock-Jin Chung, Ian Carley, Shamsun Nahar, Tae Hoon Kim, Jae-Wook Jeong

4:45 p.m. - 5:00 p.m.

O-018: Impaired Bone Morphogenetic Protein Signaling Pathways Disrupt Decidualization in Endometriosis
Diana Monsivais, Zian Liao, Suni Tang, Peixin Jiang, Ting Geng, Timoty Dunn, Joie Guner, Linda Alpuing Radilla, Xiaoming Guan

5:00 p.m. - 5:15 p.m.

O-019: Higher Prevalence of Somatic Cancer Driver Mutations in Deeply Invasive Endometriosis and Endometriomas Compared to Superficial Endometriosis
Maria Facadio Antero, Elizabeth Schlant, Lucy Chen, Bhuchitra Singh, Laura Courtright, Joshua Brennan, Briana Winer-Centurelli, Tian-Li Wang, Ie-Ming Shih, James Segars

5:15 p.m. - 5:30 p.m.

O-020: SPIRIT Long-Term Extension Study: Subgroup Analyses of Dysmenorrhea and Non-Menstrual Pelvic Pain Response through 104 Weeks
Christian Becker, Sawsan As-Sanie, Julie Perry, Yi Zhong, Neil Johnson

Parturition I

Moderators:
K. Joseph Hurt, MD, PhD
Hanah Georges, PhD

Meeting Room 8/15
Meeting Level - East

3:30 p.m. - 3:45 p.m.

O-021: Inflammation-Associated Preterm Labor via Progesterone Withdrawal in Decidual Stromal Cells
Angela DeTomaso, Hyeyon Kim, Jacqueline Shauh, Sarah Alserhaid, Soma Chakravarti, Anika Adulla, Maya Ghoul, Kelsey Lopez, Sarah Zigo, Lauren J Park, Emily McKinney, David Hackney, Sam Mesiano

3:45 p.m. - 4:00 p.m.

O-022: HLA-G: A Frontline Immunomodulator at the Chorio-Decidual Interface
Ryan C V Lintao, Lauren Richardson, Jenieve Chapa, Leslie Michelle M Dalmacio, Ramkumar Menon

4:00 p.m. - 4:15 p.m.

O-023: Maximal Delay to Administer HSJ633, an Allosteric Anti-IL-6R, After Inducing Preterm Labor to Prevent Preterm Birth and Adverse Neonatal Outcomes
France Côté, Aurélie Faucher, Maria El-Azzi, Marie-Pénélope Simard, Béatrice Ferri, Tiffany Habelrih, Xin Hou, Christiane Quiniou, David Olson, Sylvain Chemtob

4:15 p.m. - 4:30 p.m.

O-024: Whole Cervix Imaging of Collagen, Muscle, and Cellularity in Term and Preterm Patient
Wenjie Wu, Zhexian Sun, Hansong Gao, Yuan Nan, Josephine Lau, Yiqi Lin, Haonan Xu, Hannah R Krigman, Qing Wang, Yong Wang

4:30 p.m. - 4:45 p.m.

O-025: Circulating Levels of miRNA Biomarkers Measured at 12 Weeks Predict Subsequent Fetal Growth Restriction and Preterm Birth
Maria Arianoglou, Sung H Kim, Lucia Riaposova, David A MacIntyre, Lynne Sykes, Phillip R Bennett, Vasso Terzidou

4:45 p.m. - 5:00 p.m.

O-026: Phosphorylation of ERK via Hyaluronan Signaling Regulates the Barrier Mechanism at Cervical Epithelium
Yusuke Ueda, Shanmugapriyaa Madhukaran, Mala Mahendroo

5:00 p.m. - 5:15 p.m.

O-027: Effect of Ephedrine, Phenylephrine, and Norepinephrine on Myometrial Contractility
Joseph Park, Oksana Shynlova, John Kingdom, Stephen Lye, Mrinalini Balki

5:15 p.m. - 5:30 p.m.

O-028: Fetal Intramuscular Administration of Rytvela Partially Resolved LPS-Induced Inflammation in Preterm Sheep
Yuki Takahashi, Tsukasa Takahashi, Erin L Fee, Haruo Usuda, Sylvain Chemtob, David M Olson, Jeffrey A Keelan, Matthew Kemp

Placenta I

Moderators:
Simcha Yagel, MD
Cathy Vaillancourt, PhD

Meeting Room 11
Meeting Level - East

3:30 p.m. - 3:45 p.m.

O-029: Lessons Learned in Single-Cell vs. Single-Nuclei RNA-Sequencing of the Placenta in Health and Disease
Niv Skrabianskis, Inbal Admati, Hannah Hochgerner, Osnat Ophir, Amit Ziesel, Simcha Yagel, Zeev Weiner, Solt Ido

3:45 p.m. - 4:00 p.m.

O-030: Improving Analysis and Interpretation of Single-Cell Sequencing Approaches
Sabrena Rutledge, Arun Seetharam, Teka Khan, R. Michael Roberts, Geetu Tuteja

4:00 p.m. - 4:15 p.m.

O-031: Mid-late Gestation Leptin Infusion Induces Placental Mitochondrial and Endoplasmic Reticulum Unfolded Protein Responses in a Mouse Model of Preeclampsia
Jessica L Faulkner, Mayumi Takano, Safia Ogbi, Wen Tong, Masahiko Nakata, Tereza Cindrova-Davies, Dino A Giussani

4:15 p.m. - 4:30 p.m.

O-032: The Epigenetic Factor PHF13 Governs Trophoblast Stemness and Differentiation
Yingshi Ouyang, Elena Sadovsky, Tianjiao Chu, Yoel Sadovsky

4:30 p.m. - 4:45 p.m.

O-033: Mitigation of Placental Insufficiency and Fetal Growth Restriction through IGF1 Gene Therapy in a Guinea Pig Model
Baylea Davenport, Rebecca Wilson, Helen Jones

4:45 p.m. - 5:00 p.m.

O-034: Multiomics Analysis of Placental Dysfunction in Obstetric Disorders
Samantha Piekos, Oren Barak, Nathan Price, Leroy Hood, Yoel Sadovsky

5:00 p.m. - 5:15 p.m.

O-035: SINE RNA in Imprinted microRNA Clusters: A Key Player in Placental Intrinsic Defense Against Various Pathogens
Hana Totary-Jain, Ishani Wickramage, Max Raggio, Charles Lockwood, Umit Kayisli, Ozlem Guzeloglu-Kayisli

5:15 p.m. - 5:30 p.m.

O-036: Macrophage Polarization and Function at the Maternal-Fetal Interface is Both Pro- and Anti-Inflammatory in the Setting of Intrauterine Infection
N Pithia, G Protti, G Del Vecchio, C Chougnet, M Cappelletti, F Ma, L Miller, M Pellegrini, A Jobe, P Presicce, S Kallapur

Maternal Health & Biology

Moderators:
George Osol, PhD
Kaela Varberg, PhD

Meeting Room 12
Meeting Level - East

3:30 p.m. - 3:45 p.m.

O-037: Influenza A Virus Disease Severity and Pathogenesis in a Pregnant Non-Human Primate Model
Orlando Cervantes, T Lewis, H Huang, M Fredericks, J Munson, B Del Rosario, C English, B Curtis, M Berg, S Wangari, S Kapnadak, B Altemeier, S Dross, A Germond, A Baldessari, R Van Abel, M Dacanay, YY Wu, C Fountain, H Li, D Fuller, Kristina Adams Waldorf

3:45 p.m. - 4:00 p.m.

O-038: Preeclampsia Attenuates Middle Cerebral Artery Resistance Post-Pregnancy in the Setting of Sustained Hypertension
Jonathan W Ray, Xuming Sun, Hossam Shaltout, Victor M Pulgar, Liliya M Yamaleyeva

4:00 p.m. - 4:15 p.m.

O-039: Identification of Unique Epithelia Lineage Specification Patterns in the Cervix during Pregnancy
ShanmugaPriyaa Madhukaran, Mala Mahendroo

4:15 p.m. - 4:30 p.m.

O-040: Maternal Obesity Impacts Enterobacteriaceae Strains in Human Newborns That Increase TMAO and Provoke Hepatic Fibrosis in Adulthood
Rashi Sehgal, April Teague, Wanke Zhao, William P Robins, Karen R Jonscher, Jacob E Friedman

4:30 p.m. - 4:45 p.m.

O-041: Reduced Maternal Cardiac Output in Pregnancies Complicated by Placental Insufficiency May Not Be Due to Lower Fetal Weight as Measured by Cardiovascular MRI in Sheep
Steven KS Cho, Jack RT Darby, Stacey L Holman, Anna L David, Christopher K Macgowan, Andrew Melbourne, Janna L Morrison, Mike Seed

4:45 p.m. - 5:00 p.m.

O-042: Maternal Obesity Dampens Changes in Metabolic Flexibility across Gestation
Taysir Mahmoud, Begum Aydogan-Mathyk, Patrick Catalano, Sai Krupa Das, Perrie Faye O'Tierney-Ginn

5:00 p.m. - 5:15 p.m.

O-043: PFAS Exposures During Pregnancy and Midlife Cardiovascular Disease Risk Factors in Women of the Project Viva Cohort
Eva Laura Siegel, Jordan Arvayo, Emma V Preston, Sheryl L Rifas-Shiman, Emily Oken, Marie-France Hivert, Jorge Chavarro, Tamarra James-Todd, Ami Zota

5:15 p.m. - 5:30 p.m.

O-044: Periconceptional Obesity and Diet Independently Change the Gut Microbiota in Pregnant Mice and Alter Maternal Immune Responses and Pregnancy Outcome
Lieske Wekema, Nicole Schenkelaars, Régine Steegers-Theunissen, Sam Schoenmakers, Marijke Faas

Reproductive Biology I

Moderators:
Sonia Herraiz, PhD
Aymara Mas Perucho, PhD

Meeting Room 13
Meeting Level - East

3:30 p.m. - 3:45 p.m.

O-045: Unravelling the Role of Thrombospondin-1 (THBS1) in the Ovary: Reproductive Characterization of a THBS1 Knockout Mouse Model
Noelia Ramírez-Martín, Anna Buigues, Jessica Martínez, Cristina Rodríguez-Hernández, Paula Blázquez, Antonio Pellicer, Sonia Herraiz

3:45 p.m. - 4:00 p.m.

O-156:  Effects of Superovulation on Ovarian Perifollicular Angiogenesis
Georgia Mappa, Nicoals M Orsi, Clare Freer

4:00 p.m. - 4:15 p.m.

O-046: Temporal Transcriptomic Profiles Suggest p53-Mediated Apoptotic Pathway is Involved in Cyclophosphamide Treated Mouse Ovaries
Xia Hao, Africa Vincelle Nieto, Palomares Reyes Arturo, Palomares Reyes Armando, A. Rodriguez-Wallberg Kenny

4:15 p.m. - 4:30 p.m.

O-047: Lowering Insulin Alleviates Age- and Diet-Induced Reproductive Dysfunction in Female Mice
Faria Athar, Liam Hall, Nicole Templeman

4:30 p.m. - 4:45 p.m.

O-157: Obesity Induced Disruption Of The Murine Gut Microbiota Impairs Ovarian Function
Sarah Munyoki, Julie P Goff, Erin Wilderoter, Carlos Castro, Anthony J Zeleznik, Stacy G Wendel, Miguel Brieño-Enriquez, Eldin Jašarević

4:45 p.m. - 5:00 p.m.

O-048: Growth Factor-Enriched Xenogeneic Ovarian ECM Hydrogels: A Promising Treatment for Premature Ovarian Failure
Emilio Francés-Herrero, Clara Bueno-Fernandez, Adolfo Rodríguez-Eguren, María Gómez-Álvarez, Amparo Faus, Alexandra Soto-Prado, Patricia Sebastian-Leon, Patricia Diaz-Gimeno, Ana Díaz, Antonio Pellicer, Irene Cervelló

5:00 p.m. - 5:15 p.m.

O-049: Engineering Synthetic Hydrogels for Modeling Vascularized Endometriosis Lesions in Microfluidic Devices
Lauren Pruett, Angela Jiao, Ellen Kan, Ryan Ogi, Matthew Johnson, Priyatanu Roy, David Trumper, Linda Griffith

5:15 p.m. - 5:30 p.m.

O-158: Stromal Progesterone Receptor is Crucial for Establishing Mouse Uterine Receptivity and Decidual Response
Sylvia C. Hewitt, Barbara Nicol, Frank Orellana, Humphrey Yao, Francesco J DeMayo

5:45 p.m. - 7:15 p.m.

Connection Corners
*Ticketed

East Ballroom A
Convention Level - East

7:00 a.m. - 6:00 p.m.

Registration

Lobby
Convention Level - East

8:00 a.m. - 8:10 a.m.

 Presidential Welcome

Ballroom BC
Convention Level - East

8:10 a.m. - 9:00 a.m.

President's Distinguished Lecture II

Tracy Bale, PhD
University of Colorado, Anschutz Medical Campus
Aurora, CO, USA

Ballroom BC
Convention Level - East

9:00 a.m. - 11:00 a.m.

Poster Session II

Exhibit Hall B
Convention Level - East

11:00 a.m. - 12:30 p.m.

Concurrent Oral Presentations II

Developmental Programming I

Moderators:
Janice Bailey, PhD
Sarah Wernimont, MD, PhD

Meeting Room 1
Meeting Level - East

11:00 a.m. - 11:15 a.m.

O-050: Breaking Rules: The Complex Relationship between DNA Methylation and X-Chromosome Inactivation in the Human Placenta
Amy M Inkster, Allison M Matthews, Carolyn J Brown, Wendy P Robinson

11:15 a.m. - 11:30 a.m.

O-051: Bioaccumulation of Microplastics in Placentae Associated with Environmental Chemical Exposures and Obstetrical Outcomes
Enrico R. Barrozo, Marcus A. Garcia, Michael D. Jochum, Eliane El Hayek, Eliseo F. Castillo, Jorge Gonzalez-Estrella, Cynthia Shope, Melissa A. Suter, Matthew J. Campen, Kjersti M. Aagaard

11:30 a.m. - 11:45 a.m.

O-052: Biomarkers of Chronic Stress in Association with Maternal ‘Vulnerability’ and the Impact on Embryonic Growth: The Rotterdam Periconceptional Cohort (Predict Study)
Sofie KM van Zundert, Lenie van Rossem, Mina Mirzaian, Sten P Willemsen, Lotte W Voskamp, Wietske AP Bastiaansen, Darya Nikpayam, Pieter H Griffioen, Wim F Schilleman, Anton HJ Koning, Sjoerd AA van den Berg, Melek Rousian, Ron HN van Schaik, Régine PM Steegers-Theunissen

11:45 a.m. - 12:00 p.m.

O-053: Periconceptual CoQ10 Effects on Reproductive and Perinatal Consequences from Maternal Dyslipidemia
Abigail Klein, Tricia Larsen, Tyler Gandy, Kyle Siemers, Ross Lanier, Michelle Baack

12:00 p.m. - 12:15 p.m.

O-054: Periconceptional Stress Signalling through O-GlcNAcylation: Effects on Placental Development
Xueli Liu, Lewis Renshall, Angelos Evangelinos, Carolyn Jones, Daniel Brison, Adam Stevens, Peter Ruane, John Aplin, Mark Dilworth, Melissa Westwood

12:15 p.m. - 12:30 p.m.

O-055: Conserved DNA Methylation Signatures in Neonatal Blood of Humans and Guinea Pigs Exposed to Antenatal Corticosteroid Treatment
Bona Kim, Alisa Kostaki, Stephen Matthews

Fetus I

Moderators:
Paul Rozance, MD
Kimberley Botting, PhD

Meeting Room 2/3
Meeting Level - East

11:00 a.m. - 11:15 a.m.

O-056: Decoding the Mystery of Recurrent Pregnancy Loss: Revelations from Genome Sequencing
Mona Aminbeidokhti, Amrita Nagasuri, Hakan Cakmak, Eleni Jaswa, Maureen Baldwin, Alison Edelman, Elizabeth Pollard, Michael Snyder, Marina Sirota, Christina Tise, Jonathan Bernstein, Mary Stephenson, Ruth Lathi, Svetlana Yatsenko, Aleksandar Rajkovic

11:15 a.m. - 11:30 a.m.

O-057: Early Origins of Cardiac Dysfunction in an Embryonic Model of Obstructive Sleep Apnea During Development
Jacob Vincent, Sara Perelmuter, Natasha I. Cavell, Mathilde Lucas, Youguo Niu, Jack P. Barry, Sage G. Ford, Rachael C. Crew, Anna L.K. Cochrane, German A. Arenas, Bernardo J. Krause, Lucas C. Pantaleao, Susan E. Ozanne, Dino A. Giussani

11:30 a.m. - 11:45 a.m.

O-058: Replacement Insulin during IGF-1 Infusion Increases Body Growth and Myoblast Proliferation in Fetal Sheep
Jane Stremming, Neeka Barooni, Eileen I Chang, Alicia White, Paul J Rozance, Carrie E McCurdy, Laura D Brown

11:45 a.m. - 12:00 p.m.

O-059: Testing a Genetic Risk Score for Birth Weight for Generalizability Across Races
Maryam Zeinomar, Lisa Pappas, Merry Joseph, Joseph Mims, Rafael Guerrero, Barry Moore, Nathan R. Blue

12:00 p.m. - 12:15 p.m.

O-060: Astrocytes Modulate Drug Transporter Activity in Human Fetal Brain Endothelial Cells
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Rebecca Krichker, Cathal Rollins, Stephen G. Matthews

12:15 p.m. - 12:30 p.m.

O-061: The Extremely Preterm Ovine Fetus Lacks the Ability to Compensate for Loss of Placental Growth Factor Input When Undergoing Artificial Placenta Treatment
Sean William David Carter, Haruo Usuda, Hideyuki Ikeda, Erin L Fee, Masatoshi Saito, Matthew W Kemp

Preeclampsia I

Moderators:
Anna David, PhD FRCOG
Liping Feng, MD

Meeting Room 8/15
Meeting Level - East

11:00 a.m. - 11:15 a.m.

O-062: Placenta-Derived Small Extracellular Vesicles Impair Maternal Endothelial Function via Ceramide-Induced Mitochondrial Fission in Early-Onset Preeclampsia
Jonathan William Ausman, Martin Post, Ori Nevo, Isabella Caniggia

11:15 a.m. - 11:30 a.m.

O-063: Extracellular Mitochondrial DNA Impairs Maternal Endothelial Function in Rat Aorta during Pregnancy
Nataliia Hula, Renee Oliveira da Silva, Gabrielle Kelly, Isabelle K. Gorham, Taiming Liu, Arlin B. Blood, Nicole R. Phillips, Styliani Goulopoulou

11:30 a.m. - 11:45 a.m.

O-064: Single-Cell Analysis of Preeclampsia with and without IUGR: Placental Insights
Inbal Admati, Niv Skarbianskis, Hannah Hochgerner, Osnat Ophir, Simcha Yagel, Amit Zeisel, Ido Solt

11:45 a.m. - 12:00 p.m.

O-065: Anti-Ferroptotic Drugs as a Novel Tool to Reduce Placental sFlt-1 Secretion: A Potential Treatment for Preeclampsia
Sapir Lianski, Tehila Mizrachi, Shirin Elhaik-Goldman, Debra Goldman-Wohl, Simcha Yagel, Ofer Beharier

12:00 p.m. - 12:15 p.m.

O-066: LOX-1 Inhibition Selectively Prevents Aortic but Not Cerebral Stiffness in a Model of Preeclampsia
Jennifer Lynne Anderson, Tremble M Sarah, McGreer A. Jayden, Tainter-Gilbery V. Abigayle, Cipolla J. Marilyn

12:15 p.m. - 12:30 p.m.

O-067: The Cardioselective Beta-1 Blockers, Bisoprolol and Nebivolol, Affect Fetoplacental Vascular Function
Teresa Tropea, Paul Brownbill, Heagerty M. Anthony, Jenny E. Myers

Gynecology II

Moderators:
Jose Teixeira, PhD
Zian Liao

Meeting Room 11
Meeting Level - East

11:00 a.m. - 11:15 a.m.

O-068: Coenzyme Q-10 Reduces the Aberrant Production of Extracellular Matrix Proteins in Uterine Leiomyomas through Its Effect on the Transforming Growth Factor Beta 3 Pathway
Charlene Galvez Echague, Minnie Malik, Paul Driggers, William Catherino

11:15 a.m. - 11:30 a.m.

O-069: Phthalate Metabolite Exposure Induces Accumulation of Oxidative Stress and Extracellular Matrix in Pre-Fibroid Myometrial Stem Cell-Derived 3D Organoids: Modeling a Fibroid Phenotype
Somayeh Vafaei, Mervat M Omran, Qiwei Yang, Ami R. Zota, Mohamed Ali, Ayman Al-Hendy

11:30 a.m. - 11:45 a.m.

O-070: E-proteins Regulates Estrogen Signaling and Immune Function during Endometriotic Lesion Development
Yong Song, Gregory W. Burns, Erin Vegter, Samantha Hrbek, Awatef Ayesh, Xiuyuan Jin, Ke Liu, Asgerally T. Fazleabas

11:45 a.m. - 12:00 p.m.

O-071: Potential for Diagnosis of Endometriosis Using ^99mTc-Maraciclatide
Tatjana Gibbons, Druin Burch, Jon Barnett, Sarah Cade, Richard Graham, Patel Neel, Krina Zondervan, Becker Christian

12:00 p.m. - 12:15 p.m.

O-072: Simvastatin and Mifepristone Act Synergistically to Inhibits PR-A/B Signaling in Uterine Leiomyomas
Gregory W. Kirschen, Sadia Afrin

12:15 p.m. - 12:30 p.m.

O-073: Differential Expression of Race and MED12-Associated Long Non-Coding RNAs in Uterine Leiomyomas
Tsai-Der Chuang, Nhu Ton, Shawn Rysling, Derek Quintanilla, Drake Boos, Omid Khorram

Parturition II

Moderators:
Sarah England, PhD
Ramón Lorca, PhD

Meeting Room 12
Meeting Level - East

11:00 a.m. - 11:15 a.m.

O-074: Mapping Changes in Uterine Contractility during the Ovulatory Cycle with Wide-Area Calcium Imaging in Live Mice
David Combs, Eric Moult, Andrew Preecha, Shahinoor Begum, Sarah K England, Adam E Cohen

11:15 a.m. - 11:30 a.m.

O-075: Noninvasive Uterine Maturation Biomarkers Modeled through Electromyometrial Imaging and Spike Propagation Graph Analysis
Zichao Wen, Peinan Zhao, Yuelin Li, Yiqi Lin, Hansong Gao, Xinyu Zhang, Yuan Nan, Yong Wang

11:30 a.m. - 11:45 a.m.

O-076: The Opioid Buprenorphine Induces Fetal Membrane Sterile Inflammation in Part through Toll-Like Receptor 4 Activation
Tatyana Lynn, Ryan M Logan, Kimberly A Yonkers, Vikki M Abrahams

11:45 a.m. - 12:00 p.m.

O-077: Vaginal Administration of Live Biotherapeutic Lactobacillus Crispatus CTV-05 in Pregnancy Leads to Persistent Colonisation and Reduces Inflammation
Erna Bayar, Ryan L Love, Yun S Lee, Sherrianne Ng, Belen Gimeno-Molina, Thomas Parks, Peter P Lee, Phillip R Bennett, Lynne Sykes, David A MacIntyre

12:00 p.m. - 12:15 p.m.

O-078: Tissue-Specific Fetal Brain and Membrane Inflammasome Activation by Choriodecidual Ureaplasma parvum Infection in a Rhesus Macaque Model
Sudeshna Tripathy, Larry S Sherman, Irina Burd, Meredith A Kelleher

12:15 p.m. - 12:30 p.m.

O-079: Cervical Epigenome Profiling Early in Pregnancy for Insight into Perinatal Outcomes
Devon O'Brien, Julie Vircks, Bradley Belden, Rebecca Biswell, Nick Nolte, Daniel Louiselle, Rana Elounais, Bong Nguyen, Elin Grundberg, Devika Maulik

Reproductive Endocrinology and Infertility I

Moderators:
Anna Knight, PhD
Sarah Cromack, MD

Meeting Room 13
Meeting Level - East

11:00 a.m. - 11:15 a.m.

O-080: Correlation between Uterine Fluid Leukocytes at the Time of Frozen Embryo Transfer and Pregnancy Outcomes
Suset Rodriguez, Laura Padula, Eva Fisher, Mohammed Ibrahim, Janice Moscoso, Michael Paidas, George Attia, Natasa Strbo

11:15 a.m. - 11:30 a.m.

O-081: Testis-Specific Exosomes Protect Testicular Damage through p38MAPK/ERK and AKT Signaling Pathways in Prepubescent Mice: A Paradigm Shift in Fertility Preservation
Farzana Liakath Ali, Omer Raheem, Hang-Soo Park, Analea Beckman, Mohammad Mousaei, Ayman Al-Hendy

11:30 a.m. - 11:45 a.m.

O-082: Peak Endometrial Thickness is Not Predictive of Live Birth Rate in Patients Undergoing Frozen Embryo Transfer
Haley G. Genovese, Stephanie F. Willson, Baris Ata, Nicolas Garrido, Marie D. Werner, Emre Seli

11:45 a.m. - 12:00 p.m.

O-083: Endometrial Host-Microbiome Interactions through Immune Defense Mechanism and GPCR Signaling in Reproductive Health
Marta Gonzalez-Monfort, Bruno Toson, David Perez-Villaroya, Yong Yue, Jun Yin, Veronica Llorens-Rico, Felipe Vilella, Carlos Simon, Inmaculada Moreno

12:00 p.m. - 12:15 p.m.

O-084: Assisted Reproductive Technology (ART) Pregnancies Display an Increase in Placentation Abnormalities Compared to Unassisted Pregnancies or Pregnancies from Non-IVF Fertility Treatment (NIFT) in Patients with Sub/Infertility
David Huang, Jennifer Qin, Amanda Adeleye, Paolo Rinaudo, Lydia Zablotska, Marcelle Cedars

12:15 p.m. - 12:30 p.m.

O-085: Alya Purple: Patient-Specific Multi-Scale, Multi-Physics Simulations of Human Uterine Contractions and Peristalsis during Pregnancy and the Menstrual Cycle
Yiqi Lin, Jazmin Sierra, Sicheng Wang, Constantine Butakoff, Wenjie Wu, Yuan Nan, Mariano Vazquez, Yong Wang

12:30 p.m. - 1:30 p.m.

Diversity, Equity & Inclusion Forum: Addressing Health Equity Across Geographic and Reproductive Health Perspectives
*Boxed lunches were available for purchase through online registration only.

Moderators:
Shathiyah Kulandavelu, PhD
Michelle Debbink, MD, PhD

The 2024 DEI Forum will consist of a panel of diverse experts including:

Bo Jacobsson, MD, PhD
Professor
Sahlgrenska University Hospital/University of Gothenburg, Sweden

Saraswathi Vedam, PhD, RM, FACNM Sci D(hc)
Principal, Birth Place Lab
Professor, University of British Columbia Midwifery, Canada

Elizabeth Bonney, MD, MPH
Professor
University of Vermont, USA

Ballroom BC
Convention Level - East

1:45 p.m. - 3:45 p.m.

Concurrent Mini-Symposia II

Circadian Rhythmicity and Lifelong Health

Moderators:
Bo Jacobsson, MD, PhD
Juanita Jellyman, PhD

Meeting Room 13
Meeting Level - East

1:45 p.m. - 2:15 p.m.

Circadian rhythms in the placenta
Peter Mark, PhD

2:15 p.m. - 2:45 p.m.

Perinatal time cues and potential acute and long-term health effects
Thomas Erren, MD, MPH

2:45 p.m. - 3:15 p.m.

Timing and Pregnancy Outcomes
Sarah England, PhD

3:15 p.m. - 3:45 p.m.

Sexual dimorphism and imprinting in circadian entrainment of metabolism and behavior
Janine LaSalle, PhD

The Mighty Mitochondrion: Cell Powerhouse and Beyond

Moderators:
Michelle Baack, MD
Stella Goulopoulou, PhD

Meeting Room 11
Meeting Level - East

1:45 p.m. - 2:15 p.m.

Circulating cell-free mitochondrial DNA in preeclampsia: pathogenic trigger or marker of stress?
Stella Goulopoulou, PhD

2:15 p.m. - 2:45 p.m.

Small but powerful messengers: The contribution of placental small extracellular vesicles to maternal mitochondrial homeostasis in preeclampsia
Isabella Caniggia, MD, PhD

2:45 p.m. - 3:15 p.m.

Oocyte mitochondria: Key regulators of oocyte and ovary development
Deepak Adhikari, PhD

3:15 p.m. - 3:45 p.m.

Oocyte mtDNA supplementation and developmental outcome
Justin St John, PhD

Don't Forget Dad! - Paternal Influence on Disease Programming

Moderators:
Claire Roberts, PhD
Bernardo Krause, PhD

Meeting Room 2&3
Meeting Level - East

1:45 p.m. - 2:15 p.m.

Understanding the ‘sperm RNA code’ for epigenetic inheritance with emerging tools
Qi Chen, MD, PhD

2:15 p.m. - 2:45 p.m.

Glucocorticoids, the Epididymis and Transgenerational Transmission
Steve Matthews, PhD

2:45 p.m. - 3:15 p.m.

tRNA fragments – transferring information between generations
Ana Boskovic, PhD

3:15 p.m. - 3:45 p.m.

Intergenerational inheritance of obesity and hepatic steatosis: The role of germline microRNAs
Jose Jimenez-Chillarón, PhD

Cutting Edge Technologies in Reproduction

Moderators:
Joop S.E. Laven, MD, PhD
Sophie Petropoulos, PhD

Meeting Room 8/15
Meeting Level - East

1:45 p.m. - 2:15 p.m.

Single-cell genomics in reproduction and development
Sophie Petropoulos, PhD

2:15 p.m. - 2:45 p.m.

Single cell genomics and ovarian function and dysfunction
Aleksandar Rajkovic, MD, PhD

2:45 p.m. - 3:15 p.m.

Navigating PCOS Complexities through Cutting-Edge Methods and Technologies
Elisabet Stener-Victorin, PhD

3:15 p.m. - 3:45 p.m.

Synthetic Ex Utero Embryogenesis:from Naive Stem Cells to Complete Embryo Models
Jacob (Yaqub) H. Hanna, MD PhD

Artificial Intelligence in Reproductive Sciences

Moderators:
Bas van Rijn, MD, PhD
Murilo Graton, PhD

Meeting Room 1
Meeting Level - East

1:45 p.m. - 2:15 p.m.

Application of Artificial Intelligence in the IVF Laboratory
Charles Bormann, PhD

2:15 p.m. - 2:45 p.m.

Decoding Preeclampsia: AI Technologies to Predict Maternal Risk
Vesela P. Kovacheva, MD PhD

2:45 p.m. - 3:15 p.m.

The power and pitfalls of AI in global reproductive health
Bethany Hedt-Gauthier, PhD

3:15 p.m. - 3:45 p.m.

AI-based tools for prediction of myometrial tumors
Aymara Mas Perucho, PhD

Advanced Imaging: Connecting Biophysics with Reproduction

Moderators:
John Kingdom, MD
Bin Gu, PhD

Meeting Room 12
Meeting Level - East

1:45 p.m. - 2:15 p.m.

Prenatal Diagnosis of Human Placental Diseases: integration of imaging methods and Placenta Growth Factor (PlGF)
John Kingdom, MD

2:15 p.m. - 2:45 p.m.

High intensity focused ultrasound (HIFU) for twin-twin transfusion syndrome: challenges and successes
Christoph Lees, MD, FRCOG

2:45 p.m. - 3:15 p.m.

Placental and fetal MRI in detecting fetal growth restriction
Janna Morrison, PhD

3:15 p.m. - 3:45 p.m.

Enhancing Endometriosis Imaging to Enhance Clinical and Surgical Care
Mathew Leonardi, MD, PhD, FRCSC

3:45 p.m. - 4:00 p.m.

Coffee Break

Meeting Level - East

4:00 p.m. - 5:30 p.m.

Concurrent Oral Presentations III

Global Population Health

Moderators:
Dharani Hapangama, BSc, MBChB, MD FRCOG
Shathiyah Kulandavelu, PhD

Meeting Room 1
Meeting Level - East

4:00 p.m. - 4:15 p.m.

O-086: Preconception Paternal Adherence to a Prudent Diet Pattern: A Shield Against Accelerated Child Growth
Antonio Rossi, Zheng Hao Chen, Myrtha Reyna-Vargas, Piushkumar Mandhane, Elinor Simons, Stuart Turvey, Theo Moraes, Padmaja Subbarao, Kozeta Miliku

4:15 p.m. - 4:30 p.m.

O-087: Use of Antiviral Medication during Pregnancy Reduces the Risk of Preeclampsia
Alice Zancanaro, Susanne Hesselman, Roxanne Hastie, Anna Fogdell-Hahn, Theodora Kunovac-Kallak, Anna-Karin Wikström, Susanne Lager

4:30 p.m. - 4:45 p.m.

O-088: Association between Neighborhood Poverty and Pregestational Comorbidities in a Birthing Population from a Segregated Region
Nigel Madden, Samanvi Kanugula, Lynn Yee, Joe Feinglass

4:45 p.m. - 5:00 p.m.

O-089: Prenatal Antidepressant Exposure and Long-Term Child Development: A Population-Based Cohort Study
Amanda Nitschke, Naomi Phagau, Paramdeep Kaur, Brenda Poon, Martin Guhn, Tim Oberlander, Gillian Hanley

5:00 p.m. - 5:15 p.m.

O-090: Reframing the Economic Arguments for Improving Obstetrical Care: Saving Money Costs Too Much
Mark I. Evans, Gregory F Ryan, David W Britt, George S Mussalli, Jaqueline Worth, Christian Macedonia, Lawrence D Devoe

5:15 p.m. - 5:30 p.m.

O-091: The Economic Burden of Uterine Fibroids in the United States 2022: A Comparative Cost-Analysis
D. Hazimeh*, A. Coco*, I. Casubhoy, J. Segars, B. Singh
*= Co-First Authors

Developmental Programming II

Moderators:
Daniel Hardy, Dphil
Kristin Connor, PhD

Meeting Room 2/3
Meeting Level - East

4:00 p.m. - 4:15 p.m.

O-092: Maternal Obesity Causes Cardiac Contractile Dysfunction in Mouse Fetuses In Utero
Gabrielle K. Crombie, Owen R. Vaughan

4:15 p.m. - 4:30 p.m.

O-093: iR-21-5p Protects Embryos Against Developmental Hypoxia-Induced Cardiac Dysfunction
Ranya V. Kumar, Youguo Niu, Sage G. Ford, Rachael C. Crew, Anna L.k. Cochrane, German A. Arenas, Dino A. Giussani, Bernardo J. Krause

4:30 p.m. - 4:45 p.m.

O-094: Maternal High-Fat Diet Affects Lung Function in the Newly Weaned Offspring
Yem J Alharithi, Nolan Gregg, Kayla R Williams, Sushil Kumar, Zhenying Nie, Alina Maloyan

4:45 p.m. - 5:00 p.m.

O-095: Beyond Birthweight: Unravelling the Roles of Genetics and Early Life Nutrition in Mitigating Child Obesity
C A Wang, K L Connor, S Mohammadkhani, S J Lye, T A Mori, L J Beilin, W H Oddy, C E Pennell

5:00 p.m. - 5:15 p.m.

O-096: Chronic Prenatal Delta-9-Tetrahydrocannabinol Exposure Impacts Offspring Neurodevelopment and Emotional Behavior
Kimberly Ryan, Elinor Sullivan, Joshue Karpf, Lyndsey Shorey-Kendrick, Christopher Kroenke, Jamie Lo

5:15 p.m. - 5:30 p.m.

O-097: Silencing Neuroinflammatory Reactive Astrocyte Activating Factors Ameliorates Disease Outcomes in Perinatal White Matter Injury
Amanda Brosius Lutz, Patricia Renz, Vera Tscherrig, Marel Steinfort, Valerie Haesler, Eric Huang, Manideep Chevali, David Rowitch, Shane Liddelow, Andreina Schoeberlein, Daniel Surbek

Reproductive Biology II

Moderators:
Diana Monsivais, PhD
Daniëlle Peterse, PhD

Meeting Room 8/15
Meeting Level - East

4:00 p.m. - 4:15 p.m.

O-098: Development and Characterization of a 3D Human Endometrium-on-a-Chip Model
Sofía Zaragozano Martínez, Javier Moncayo-Arlandi, Bruno Toson, Javier González-Fernández, Juan Pablo Grases, María Pardo-Figuerez, Ana Ochando, Carlos Simon, Felipe Vilella

4:15 p.m. - 4:30 p.m.

O-099: Establishment of In Vitro Implantation Model Using Newly Developed Endometrial Organoid
Taishi Fujimura, Isao Tamura, Toshihide Yoneda, Amon Shiroshita, Hitomi Takasaki, Yuichiro Shirafuta, Shun Sato, Norihiro Sugino

4:30 p.m. - 4:45 p.m.

O-100: 3D In Vitro Modelling of Embryo-Endometrial Interface Unravels Entosis Role on Cell-in-Cell Invasion During Human Embryo Implantation
Andrea Palomar, Irene Zorzan, Matteo Molè, Alicia Quiñonero,¹ Perter Rugg-Gunn, Francisco Domínguez

4:45 p.m. - 5:00 p.m.

O-101: A Single-Cell RNA-Seq Survey of Mouse Implantation Site Mapping the Contribution of Maternal Exogenous Bone Marrow Cells to Decidual Immune Landscape
Jacqueline Kisa, Nafeesa Abuwala, Rihao Qu, Kriti Agrawal, Hugh S Taylor, Reshef Tal

5:00 p.m. - 5:15 p.m.

O-102: The Functional Requirement for PGRMC Proteins in Uterine Decidualization and Their Role in Lipid Metabolism and RNA Biology
Nikhil Srivastava, Todd S. Paisley, Cindy A. Pru, John P Lydon, James K. Pru

5:15 p.m. - 5:30 p.m.

O-103: Interleukin-1β Induces and Accelerates Human Endometrial Stromal Cell Senescence and Impairs Decidualization via the c-Jun N-Terminal Kinase Pathway
Jie Yu, Sarah L Berga, Eric Zou, Jacara Washington, Brandon J Marzullo, Indrani C Bagchi, Milan K Bagchi, Robert N Taylor

Placenta II

Moderators:
Meghan Riddell, PhD
Camille Couture

Meeting Room 11
Meeting Level - East

4:00 p.m. - 4:15 p.m.

O-104: The Effects of Trophoblast Invasion on the Maternal Cells in the Decidua of Early Pregnancy
Andreas I Lackner, Anna-Lena Hoebler, Alexandra Trinks, Markus Morkel, Naveed Ishaque, Robert M Angelo, Juergen Pollheimer

4:15 p.m. - 4:30 p.m.

O-105: Macrophages Are Essential Regulators of Uterine Vascular Adaptation during Early Pregnancy in Mice
Sarah A. Robertson, Holly M. Groome, Chin Y. Peck, Claire T. Roberts, Alison S. Care

4:30 p.m. - 4:45 p.m.

O-106: Activin and FSTL3 Dynamics in Hemochorial Placentation
Mikaela Simon, Khursheed Iqbal, Ayelen Moreno-Irusta, Regan Scott, Marija Kuna, Kaela Varberg, Geetu Tuteja, Michael Soares

4:45 p.m. - 5:00 p.m.

O-107: Trophoblast-Specific Overexpression of Adiponectin Receptor 2 Inhibits Placental Mitochondrial Respiration in Mice
Fredrick J Rosario, Kenneth Barentsen, Jerad Dumolt, Johann Urschitz, Theresa L Powell, Thomas Jansson

5:00 p.m. - 5:15 p.m.

O-108: Assessing Placental Health via Mid-Pregnancy Maternal Serum in Congenital Heart Defects
Alyssa A Tipler, Marcella Rodriguez, Terry Morgan, Helen Jones

5:15 p.m. - 5:30 p.m.

O-109: Three-Dimensional Human Trophoblast Stem Cell Model Recapitulating Human Trophoblast Development during Pregnancy
Lishi Ma, Mark Kibschull, Yanxing Wei, Stephen Lye

Reproductive Endocrinology and Infertility II

Moderators:
Chellakkan Blesson, MPhil, PhD, HCLD
Limor Man, MD, M.Med.Sc

Meeting Room 12
Meeting Level - East

4:00 p.m. - 4:15 p.m.

O-110: Human Cathelicidin Peptide LL37 Enhances Efficacy of Mesenchymal Stem Cell-Derived Extracellular Vesicles as a Novel Treatment Approach for Polycystic Ovary Syndrome
Analea Beckman, Hang-soo Park, Mohammad Mousaei Ghasroldasht, Farzana Liakath Ali, Nina Hafner, Ayman Al-Hendy

4:15 p.m. - 4:30 p.m.

O-111: Cardiovascular Events Associated with PCOS Diagnosis in Longitudinal Cohort
Tess Cherlin, Colleen Morse, Regeneron Genetics Center, Penn Medicine BioBank, Shefali Setia-Verma

4:30 p.m. - 4:45 p.m.

O-112: Single-Cell RNA Sequencing Reveals Mechanisms of Ovarian Preservation by AMH During Chemotherapy
Ngoc Minh Phuong Nguyen, Eun Mi Chang, Duygu Saatcioglu, Motohiro Kano, Maeva Chauvin, Natalie Sicher, Aki Kashiwagi, Nicholas Nagykery, Christina Chow, Dadi Gao, Patricia K. Donahoe, David Pepin

4:45 p.m. - 5:30 p.m.

O-113: Chemotherapy Induced Pro-Apoptotic Extracellular Vesicles Transferring Caspase-8 in the Prepubertal Testis - Mechanistic Insights into Onco-Fertility Preservation in Pre-Pubertal Boys
Michael Philip Rimmer, Christopher David Gregory, Rod Mitchell

5:00 p.m. - 5:15 p.m.

O-114: B Cells Are Regulators of Menopause-Associated Weight Gain, Glucose Metabolism and Adipose Tissue Dysfunction Mainly through E2/ERa Signaling
Marisol Castillo-Castrejón, Estefania Valencia-Rincon, Stevi Johnson-Murguia, Mark L Lang, Michael B Stout, Elizabeth A Wellberg

5:15 p.m. - 5:30 p.m.

O-115: Novel Pro-Regenerative Biomaterial for Combating Genitourinary Syndrome of Menopause
Emma Isabel Zelus, Marianna Alperin, Karen L Christman

Clinical and Translational Perinatology II

Moderators:
Chiara Mando, PhD
Rahul D’Mello, MD, PhD

Meeting Room 13
Meeting Level - East

4:00 p.m. - 4:15 p.m.

O-116: The Role of Vaccination in Maternal Fetal Dyads in SARS-CoV-2 Antibody Transfer
Cathlyn Sullivan, Deepraj Pawar, Wu Hongwen, Joanathan Riel, Lauren Ching, Vivek Nerurkar, Alanna Tseng, Eileen Nakano, Men Jean Lee

4:15 p.m. - 4:30 p.m.

O-117:The Fetal Liver-Brain Axis: Zika Virus Infection Induces a Type I Interferon/Cytokine Response in Fetal Liver That Correlates with Brain Injury
Miranda Li, H Huang, A Li, A Vong, R Li, J Munson, H Zhao, E Li, S Dross, T Lewis, A Orvis, M Coleman, D Fuller, R Kapur, M Gale Jr., L Rajagopal, KM Adams Waldorf

4:30 p.m. - 4:45 p.m.

O-118: Neonatal Events and Childhood Respiratory Impairment
Cynthia Gyamfi-Bannerman, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

4:45 p.m. - 5:00 p.m.

O-119: Administration of Proteins Secreted by the Placenta Markedly Improves Outcomes in Premature Guinea Pigs
Avery C Kramer, Kelsey J Faer, Rebecca M Dyson, Alice Freeman, Theresa L Powell, Max Berry, Thomas Jansson

5:00 p.m. - 5:15 p.m.

O-120: Rytvela Prevents Preterm Birth and Neonatal Tissue Injury When Administered After the Onset of Preterm Labor While the Tocolytic Agent Nifedipine is Ineffective
Tiffany Habelrih, Béatrice Ferri, Félix Maufette-Whyte, Xin Hou, Allan Reuben, France Côté, Christiane Quiniou, David Olson, Sylvie Girard, Sylvain Chemtob

5:15 p.m. - 5:30 p.m.

5:45 p.m. - 7:00 p.m.

Presidential Address and Awards Ceremony

Ballroom BC
Convention Level - East

8:30 p.m. - 11:00 p.m.

The Featles Canadian Tour
*Ticketed

Ballroom BC
Convention Level - East

7:00 a.m. - 1:00 p.m.

Registration

Lobby
Convention Level - East

7:30 a.m. - 8:15 a.m.

SRI Member Business Meeting
*ALL SRI Members are invited to attend, including in-training members. Breakfast will be served.

Ballroom BC
Convention Level - East

8:20 a.m. - 8:30 a.m.

Welcome & Announcements

Ballroom BC
Convention Level - East

8:30 a.m. - 9:20 a.m.

The March of Dimes Richard B. Johnston Jr. MD Prize

Ballroom BC
Convention Level - East

9:30 a.m. - 11:30 a.m.

Poster Session III

11:30 a.m. - 1:00 p.m.

Concurrent Oral Presentations IV

Fetus II

Moderators:
Perrie O'Tierney-Ginn, PhD
Jin Bai

Meeting Room 1
Meeting Level - East

11:30 a.m. - 11:45 a.m.

O-121: Maternal Obesity in Pregnancy Improves Fetal Responses to Maternal Hypotension in an Ovine Model
Anna L.K. Cochrane, Rachael C. Crew, Youguo Niu, Sage G. Ford, Clement L. Cahen, Michael P Murphy, Susan E. Ozanne, Dino A. Giussani

11:45 a.m. - 12:00 p.m.

O-122: Fetal Sheep Brain DHA Content is Preserved in Fetal Growth Restriction in Spite of Lower Maternal and Fetal Plasma DHA Concentrations
Stephanie S Chassen, Stefanie Raymond-Whish, Karin Zemski-Berry, Stephanie R Wesolowski, Laura D Brown, Paul J Rozance, Theresa L Powell

12:00 p.m. - 12:15 p.m.

O-123: Support on a Pumped Artificial Placenta Circuit Increases Cardiac Energy Demand in a Fetal Pig Model
Jessica Seen Mann Chow, Mitchell C Lock, Alex J Charest-Pekeski, Steven KS Cho, Stacey L Holman, Brahmdeep S Saini, Fu-Tsuen Lee, Megan Quinn, Liqun Sun, Christoph Haller, Mike Seed, Janna L Morrison

12:15 p.m. - 12:30 p.m.

O-124: In Utero Delta-9-Tetrahydrocannabinol Exposure Adversely Affects Offspring Lung Development and Function
Adam Crosland, Matthias Schabel, Isaac Cinco, Cindy McEvoy^, Michael Davies, Lyndsey Shorey-Kendrick, Ilhem Messaoudi, Eliot Spindel, Jamie Lo

12:30 p.m. - 12:45 p.m.

O-125: Acute Fetal Hyperglucagonemia Increases Hepatic Expression of Genes Regulating Amino Acid Catabolism and Decreases Fetal Amino Acid Concentrations
Amelia R. Tanner, Marjorie A Nguyen, Sarah N Cilvik, Evgenia Dobrinskikh, Russell V. Anthony, Stephanie R. Wesolowski, Paul J. Rozance

12:45 p.m. - 1:00 p.m.

O-126: A Novel Device to Detect Fetal Asphyxia in Labour
Abu ul Hassan S Rana, Suzanne Miller, Elif Kadife, Alesia Harper, Marimuthu Palaniswami, Fiona C Brownfoot

Gynecology III

Moderators:
Marianna Alperin, MD, MS
Enrico Barrozo, PhD

Meeting Room 2/3
Meeting Level - East

11:30 a.m. - 11:45 a.m.

O-127: Pilot Data from the First Double-Blind Placebo-Controlled Vaginal Microbiota Transplantation Trial
Fatima Aysha Hussain, Agnes Bergerat, Julia Kelly, Briah Cooley, Daniel Worrall, Jiawu Xu, Aditi Kannan, Tess Brunner, Natalie Culler, Wafae El Arar, Ankita Katukota, Mary Dong, Douglas Kwon, Caroline Mitchell

11:45 a.m. - 12:00 p.m.

O-128: Extracellular Vesicles from Cervicovaginal Microbes Induced Immune Responses in Endometrial Cells
Yu Hasegawa, Andrea Joseph, Jake Robinson, Charuta Agashe, Kate O’Neill, Michal A Elovitz

12:00 p.m. - 12:15 p.m.

O-129: Chlamydia and Gonorrhea Infection in an Endocervix Microphysiologic Model
Katherine M Nelson, Daniel J Minahan, Vonetta L Edwards, Ian J Glomski, Keena Thomas, Forrest C Walker, Patrick M Bavoli, Isabelle Derré, Alison K Criss, Jacques Ravel, Jason P Gleghorn

12:15 p.m. - 12:30 p.m.

O-130: Human Vaginal Epithelial Stem Cells Are Negatively Impacted by Chemotherapy
Krystyna N. Rytel, Pamela A Moalli, Caroline Gargett, Meena Sukhwani, Gabrielle King, Kyle Orwig

12:30 p.m. - 12:45 p.m.

O-131: Novel Non-Invasive MRI Biomarkers of Interstitial Cystitis/Bladder Pain Syndrome
Julie Suyama, Sheronda Statum, Aurea Mohana-Borges, Yajun Ma, Jennifer Anger, Christine Chung, Marianna Alperin

12:45 p.m. - 1:00 p.m.

Placenta III

Moderators:
Ellen Menkhorst, PhD
Amy Wooldridge, MD

Meeting Room 8/15
Meeting Level - East

11:30 a.m. - 11:45 a.m.

O-132: Disrupted Collagen Architecture at the Previous Cesarean Scar is a Defining Pathology of Placenta Accreta Spectrum-Stop Blaming the Placenta
Lior Kashani Ligumsky, Anhyo Joneg, Haley Marks, Karrison Ibe, Guadalupe Martinez, S. Ananth Karumanchi, Laurent Bentolila, Deborah Krakow, Yalda Afshar

11:45 a.m. - 12:00 p.m.

O-133: Role of CEBPB in Early Events of Extravillous Trophoblast Cell Differentiation
Ayelen Moreno-Irusta, Malay Basu, Michael J Soares

12:00 p.m. - 12:15 p.m.

O-134: Race Differences in Energy Metabolism and Inflammatory Status of Mid-Gestation Human Placenta
Yu-Chin Lien, Mengyuan Kan, Rita Leite, Blanca E Himes, Virginia D. Winn, Samuel Parry, Jerome F. Strauss III, Rebecca A. Simmons

12:15 p.m. - 12:30 p.m.

O-135: Impact of Placental SLC2A3 RNA Interference throughout Gestation
Tori C Kennedy, Amelia R. Tanner, Cameron S. Lynch, Quinton A. Winger, Paul J. Rozance, Russ V. Anthony

12:30 p.m. - 12:45 p.m.

O-136: Characterization of Human Cytotrophoblast Cell Population Dynamics throughout Pregnancy
Olivier Schaffers, Madhavi Harhangi, Simone Verburgt, Joost Gribnau, Bas B. Van Rijn

12:45 p.m. - 1:00 p.m.

O-137: Toxoplasma gondii Polarizes Placental Trophoblast Differentiation Away from an Infection-Resistant Canonical Cell Lineage
Leah F Cabo, Rafaela J Silva, Liheng Yang, Christina J Megli, Carolyn B Coyne, Jon P Boyle

Reproductive Biology III

Moderators:
Joanne Kwak-Kim, MD, MPH
Begum Aydogan Mathyk, MD

Meeting Room 11
Meeting Level - East

11:30 a.m. - 11:45 a.m.

O-138: Human Umbilical Cord Platelet-Rich Plasma: Metabolomic, Proteomic, and Wound Healing Studies in Endometrial Stem Cells
Clara Bueno-Fernandez, Adolfo Rodríguez-Eguren, Marcos Agustina-Fernández, María Gómez-Álvarez, Emilio Francés-Herrero, Amparo Faus, Antonio Pellicer, Irene Cervelló

11:45 a.m. - 12:00 p.m.

O-139: Ovarian-Specific Extracellular Vesicles: A Novel Approach for Treating Premature Ovarian Insufficiency
Mohammad Mousaei Ghasroldasht, Farzana Liakath Ali, Hang-Soo Park, Ayman Al-Hendy

12:00 p.m. - 12:15 p.m.

O-160: The Impact of Glucocorticoids on miRNA in the Epididymis of Adult Male Guinea Pigs
Christopher Casciaro, Alisa Kostaki, Stephen Matthews

12:15 p.m. - 12:30 p.m.

O-140: Multi-Omics Profiling Reveals Regional Variations in the Healthy Fallopian Tube: A Comprehensive Analysis
Jessica Tozour, Hieu Nguyen, Sarah Johnston, Da Kuang, Jean Gabriel Rosario, Erik Nordgren, Stephen A Fisher, Junhyong Kim, Kathleen O'Neill

12:30 p.m. - 12:45 p.m.

O-141: Serial Intravascular Labeling Unravels Trafficking Patterns of Decidual Lymphocytes in the Non-Human Primate
Jessica Vazquez, Ann Mitzey, Thaddeus Golos, Aleksandar Stanic

12:45 p.m. - 1:00 p.m.

O-142: Overexpression of Endometrial Epithelial 60S Acidic Ribosomal Protein P1 Induces Histopathologic Features and Transcriptome Profiles Consistent with Endometrial Cancer
Warren B. Nothnick, Amanda Graham

Preeclampsia II

Moderators:
Phillip Bennett, PhD MD FRCOG FMedSci
Enrrico Bloise

Meeting Room 12
Meeting Level - East

11:30 a.m. - 11:45 a.m.

O-143: Activin A Persists in Maternal Serum in the Postpartum Period Suggesting an Active Role in Persistent Hypertension Following a HDP
Caroline Smith, Agnes Koczo, Alyssa Smith, Sila Yavan, Carrie Bennett, Christina Megli, Alisse Hauspurg

11:45 a.m. - 12:00 p.m.

O-144: Alternative Activation of Macrophages Driven by Aberrantly Decidualised Endometrial Stromal Fibroblasts May Be a Pathogenic Process during Placentation in Pre-Eclampsia
Olivia C Moran, Peter T Ruane, Abdullah Shahzad, Jenny E Myers, Elizabeth R Mann

12:00 p.m. - 12:15 p.m.

O-145: Circulating Inflammatory Profile in Early- and Late-Onset Preeclampsia: Contribution to Endothelial Activation
Elsa Bernier, Camille Couture, Marie-Ève Brien, Charles H Graham, Sylvie Girard

12:15 p.m. - 12:30 p.m.

O-146: First Trimester Vaginal Microbes and Immune Factors Predict Severe Preeclampsia
William F Kindschuh, Yoli Meydan, Aya Brown Kav, Heekuk Park, Julia Urban, Emily Watters, Susan Pollak, George R. Saade, Judith Chung, Brian M Mercer, William A Grobman^, David M Haas, Robert M Silver, Renu Nandakumar, Uma Reddy, Ronald Wapner, Anne-Catrin Uhlemann, Tal Korem

12:30 p.m. - 12:45 p.m.

O-147: Persistence of Circulating Cardiovascular Biomarkers Years Following a Hypertensive Disorder of Pregnancy
Austin Max Gabel, Lindsay Cheu, Mindy Pike, Alisa Kachikis, Stephen McCartney, Raj Shree

12:45 p.m. - 1:00 p.m.

O-148: Low Circulating SPINT1 at 36 Weeks Gestation Strongly Predicts Fetal Growth Restriction and Adverse Neonatal Outcomes
Tu'uhevaha Kaitu'u-Lino, Roxanne Hastie, Sue Walker, Teresa MacDonald, Ping Cannon, Tuong-Vi Nguyen, Parinaz Mehdipour, Lucy Bartho, Danica Idzes, Alexandra Roddy Mitchell, Stephen Tong

Benign & Malignant Tumors

Moderators:
Shannon Hawkins, MD, PhD
Gregory Burns, PhD

Meeting Room 13
Meeting Level - East

11:30 a.m. - 11:45 a.m.

O-149: The Pathological Reprogramming of N6-methyladenosine Epitranscriptome in Human Uterine Fibroids
Qiwei Yang, Karthigayan Shanmugasundaram, Xianbin Yu, Qinzhe Liu, Chuan He, Ayman Al-Hendy, Thomas G Boyer

11:45 a.m. - 12:00 p.m.

O-150: Bone Mineral Density After 48 Months of Elagolix + Add-Back Therapy in Women with Heavy Menstrual Bleeding Associated with Uterine Fibroids
Vicki L. Schnell, James Simon, Eric Brown, Liesl Bredeson, James Thomas, Anna Chan, Michael C. Snabes

12:00 p.m. - 12:15 p.m.

O-151: Improving the Diagnostic Accuracy of an Ovarian Cancer Triage Test Using a Joint miRNA-Protein Model
James W. Webber, Laura Wollborn, Sudhanshu Mishra, Allison Vitonis, Daniel W. Cramer, Ryan Phan, Todd Pappas, Dipanjan Chowdhury, Kevin M. Elias

12:15 p.m. - 12:30 p.m.

O-152: NGS Compartment Analysis Revealed Uniformity within the Stroma and Type-Specific Differences in the Epithelium of Endometriosis-Associated and High-Grade Serous Ovarian Carcinomas
Karolin Heinze, Ian Beddows, Bianca Ribeiro de Souza, Martin Koebel, Hui Shen, Michael Anglesio

12:30 p.m. - 12:45 p.m.

O-153: Obesity and the PTEN Mutant Endometrium
Hilary J Skalski, Madison MacLachlan, Amelia R Arendt, Shannon K Harkins, Katelyn Becker, Marc Wegener, Marie Adams, Galen Hostetter, Ronald L Chandler

12:45 p.m. - 1:00 p.m.

O-154: SERINC2 Promotes the Occurrence and Development of Cervical Cancer via Competing for Serine to Drive T Cells Exhaustion
Yixuan Sun, Qihua Peng, Xiao Li, Lipeng Hu, Xueli Zhang, Zhigang Zhang, Yincheng Teng

1:15 p.m. - 2:45 p.m.

Hot Topics & Awards Ceremony

Moderators:
Dino Giussani, MA PhD ScD FRCOG
Bo Rueda, PhD

East Ballroom BC
Convention Level - East

1:15 p.m. - 1:30 p.m.

O-161: Placental Extracellular Vesicles Modifies Future Cardiovascular Disease Development in Rodents
Sien Yee Sandy Lau, Yourong Feng, Qi Chen, Katie Groom, Charlotte Oyston, Carolyn Barrett∗, Larry Chamley

1:30 p.m. - 1:45 p.m.

O-162: Characterisation of Small Extracellular Vesicles in Endometriosis Patients: Cellular Origins and Macrophage Modulation within the Peritoneal Microenvironment
Yifan Wang, Zhixing Jin, Banayot Hosh, Ayazhan Akhatova, Erin Greaves, Rebecca Dragovic, Jen Southcombe, Christian M Becker

1:45 p.m. - 2:45 p.m.

Awards Ceremony

• President's Presenter's Awards
• Early Career Investigator Awards
• Laxmi Baxi Awards
• The Kusum Lata Excellence Awards
• Thomas McDonald Award
• Chinese Program Travel Awards
• Poster Awards