SRI 2015 Annual Meeting
SRI 2015 Annual Meeting

Society of Reproductive Investigation (SRI)


Detailed Agenda

Download the Final Program Here!

Wednesday, March 25
8:30 a.m. - 5:00 p.m. Fetal Physiology Satellite Meeting

Organizer: Lubo Zhang

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Plaza A
8:30 a.m. - 5:00 p.m. Placenta Satellite Meeting

Program Director: Helen N. Jones, Ph.D., Division of Reproductive Sciences and General Thoracic Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA

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Plaza B
8:30 a.m. - 5:00 p.m. Preterm Birth Satellite Meeting

Symposium Coordinator: Ramkumar Menon, Ph.D., Assistant Professor, Department of Obstetrics and Gynecology, Maternal-Fetal Medicine & Perinatal Research Division, The University of Texas Medical Branch at Galveston, Galveston, TX

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Yosemite B
8:30 a.m. - 5:00 p.m. Endometrium Satellite Meeting

Organizers: Professor Peter A W Rogers, Professor of Women's Health Research, University of Melbourne Department of Obstetrics & Gynecology, and Research Director, Royal Women's Hospital, Victoria, Australia
Asgi T. Fazleabas, Ph.D., Professor and Associate Chair for Research, Department of Obstetrics, Gynecology & Reproductive Biology, Director, Center for Women's Health, Co-Director, Reproductive and Developmental Sciences Program, Michigan State University, Grand Rapids, MI, USA

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Franciscan C & D
8:30 a.m. - 5:00 p.m. Myometrium Satellite Meeting

Symposium Coordinators: Rachel Tribe, Ph.D., Reader in Women's Health, Division of Women's Health, King's College London, Women's Health Academic Centre, King's Health Partners, London, UK
R. Ann Word, M.D., Professor of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

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Yosemite A
3:00 p.m. - 6:00 p.m. Registration Yosemite Foyer
5:15p.m. - 6:15 p.m. New Investigator Career Development Session: Good Grantsmanship: The Key to Success
Thomas Jansson M.D., Ph.D., University of Colorado School of Medicine
Stephen Matthews, Ph.D., University of Toronto
Plaza A
5:15 p.m. - 6:15 p.m. Mid-Career Investigator Career Development Session: Discovery and Development Process for Therapeutics and Diagnostics
Thomas J. Musci M.D., Chief Medical Officer Ariosa Diagnostics
Ken Song, M.D., Chief Executive Officer, Ariosa Diagnostics
Plaza B
6:45 p.m. - 8:00 p.m. Opening Reception Imperial A & B
Thursday, March 26
6:30 a.m. - 7:30 a.m. Bayer Breakfast Series I: What's New in Menopausal Hormone Therapy 2015?
Nanette Santoro, M.D.
Professor and E. Stewart Taylor Chair of Obstetrics and Gynecology
University of Colorado School of Medicine
Imperial A
7:00 a.m. - 8:00 a.m. Career Development Meeting (Career Development Committee) Union Square 3 - 4
7:00 a.m. - 6:00 p.m. Registration Yosemite Foyer
7:45 a.m. - 10:00 a.m. Welcome Address, New Investigator Plenary, President's Distinguished Lecture
7:45 a.m. - 8:00 a.m. President's Welcome Address
8:00 a.m. - 9:00 a.m. Presidential New Investigator Plenary Session
8:00 a.m. - 8:15 a.m. Impaired Development of Early Endometriotic Lesions in CD 44 Knockout Mice
Jennifer Knudtson, M.D.
8:15 a.m. - 8:30 a.m. Hsa-miR-30d Is Transported By Exosomes From Human Endometrial Epithelium To the Trophectoderm of Preimplantation Embryos and Modulates Embryo
Felip Vilella Mitjana
8:30 a.m. - 8:45 a.m. A Targeted Drug Delivery System for the Uterus
Jonathan Paul, Ph.D.
8:45 a.m. - 9:00 a.m. Molecular Evidence of Functional Progesterone Withdrawal in Labouring Human Myometrium
Lubna Nadeem, Ph.D.
9:00 a.m. - 10:00 a.m. President's Distinguished Lecture I
Sensing and Responding to Microbes: A Forward Genetic Approach
Bruce Beutler, M.D.
2011 Nobel Laureate in Physiology or Medicine
University of Texas Southwestern Medical Center
Raymond and Ellen Willie Distinguished Chair in Cancer Research
Director, Center for Genetics of Host Defense
Regental Professor, Department of Immunology
Continental 5 - 6
10:00 a.m. - 12:00 p.m. Poster Session I Grand Ballroom A & B
12:00 p.m. - 1:30 p.m. Lunch Symposium: Progestogens and Preterm Birth: From its Molecular Effects on the Uterus and Cervix to its Role in Prevention of Spontaneous Preterm Birth

The Current Use of Progestogens in the Clinical Prevention of Spontaneous Preterm Birth
Hy Simhan, M.D.

Physiology of Progesterone/PR Signaling in the Pregnancy Myometrium
Sam Mesiano, Ph.D.

The Role of Progestogens in Cervical Remodeling
Michael House, M.D.
12:00 p.m. - 1:30 p.m. Past President's Lunch (By invitation only) Union Square 3 - 4
1:45 p.m. - 3:45 p.m. Concurrent Oral Presentations I
Clinical Perinatology
Moderators: Craig E. Pennell, MD, MBBS, FRANZCOG, CMFM
                     Hilary A. Roeder, M.D.
Continental 1 – 3
1:45 p.m. – 2:00 p.m. Hypothalamic Pituitary Adrenal Axis Hormones Are Reduced in Obese Pregnancy
Laura Stirrat, MBCHB
2:00 p.m. – 2:15 p.m. Mid-Pregnancy Amniotic Fluid Bisphenol A Concentrations and Adverse Pregnancy Outcomes Shaofu Li, Ph.D.
2:15 p.m. – 2:30 p.m. Maternal Whole Blood Gene Expression Predicts Spontaneous Preterm Birth in Asymptomatic Women as Early as 18 Weeks Gestation Yujing Jan Heng, Ph.D.
2:30 p.m. – 2:45 p.m. Baseline Uterine Tone in Labor: Does It Matter? Kristina A. Epplin, M.D.
2:45 p.m. – 3:00 p.m. Placental Shape and Neonatal Body Composition Nicole E. Marshall, M.D.
3:00 p.m. – 3:15 p.m. Paradigm Shift: Large Neonatal Head Circumference Is More Predictive of Instrumental or Operative Delivery and Neonatal Complications Than Birthweight
Simcha Yagel, M.D.
3:15 p.m. – 3:30 p.m. White Matter Oxygenation Measured By T2* Blood Oxygen Level Dependent (BOLD) Magnetic Resonance Imaging (MRI) Is Lower in Small for Gestational Age (SGA) Fetuses Compared To Gestation Matched Healthy Controls
Fiona C. Denison, M.D.
3:30 p.m. – 3:45 p.m. Giving Birth To a Low Birth Weight Child (LBW) and Risk of Cardiovascular Disease (CVD): Effect of Traditional CVD Risk Factors
Radek Bukowski, M.D., Ph.D.
Gynecology I
Moderators: Ruth A. Word, M.D.
                     Amelie Fassbender, Ph.D.
                     Patricia T. Jimenez, M.D.
Imperial A
1:45 p.m. – 2:00 p.m. The Role of IGF2 Signaling in Fibroid Stem Cell Function and Fibroid Pathogenesis
Molly B. Moravek, M.D., MPH
2:00 p.m. – 2:15 p.m. Epigenetic Regulation of DNA Damage/Repair Signaling Pathway in Human Uterine Fibroids
Qiwei Yang, Ph.D.
2:15 p.m. – 2:30 p.m. The Decreased Endometrial Expression of Leukemia Inhibitory Factor and Interleukin-11 at the Implantation Window of Adenomyosis Patients
Chih-Feng Yen, M.D.
2:30 p.m. – 2:45 p.m. Effect of Usage and Type of Hormonal Contraception (HC) on Anti-Mullerian Hormone (AMH) Levels in Young African American Women (AAW)
Marissa L. Steinberg, M.D.
2:45 p.m. – 3:00 p.m. Tubal Ligation May Induce Quiescence of Distal Fallopian Tube Epithelia: A Potential Mechanism for Risk Reduction of Serous Carcinomas.
Ekaterina Tiourin
3:00 p.m. – 3:15 p.m. Inflammaging of Uterosacral Ligaments: A Novel Estrogen Modulated Mechanism of Pelvic Organ Prolapse
Ritsuko Iwanaga, Ph.D.
3:15 p.m. – 3:30 p.m. Silicone Vs. Water-Based Lubricant for Symptomatic Vaginal Dryness After Breast Cancer: Preliminary Findings From a Randomized Trial
Martha Hickey, M.D., Ph.D.
3:30 p.m. – 3:45 p.m. The Effects of Hormones on Skin Wrinkles and Rigidity Vary By Race: 4 Year Follow-Up for Skin Characteristics Ancillary Study of the KEEPS Trial
Carter M. Owen, M.D.
Maternal Biology and Health
Moderators: Jorge P. Figueroa, M.D., Ph.D.
                     Jayanth Ramadoss, Ph.D.
Continental 7 – 9
1:45 p.m. – 2:00 p.m. Dose Dependent Association Between Number of Consecutive Miscarriages and Cardiovascular Disease Later in Life [ndash] Evidence From a Scottish Cohort.
Marise M. Wagner, M.D.
2:00 p.m. – 2:15 p.m. Maternal Cardiovascular Risk Profile After a Pregnancy Complicated By Preterm Intrauterine Growth Restriction
Blanka Vasak, M.D.
2:15 p.m. – 2:30 p.m. Adipose Tissue Inflammation, ER Stress and Insulin Resistance in Obese Pregnant Mice With Fetal Overgrowth
Irving L. Aye, Ph.D.
2:30 p.m. – 2:45 p.m. Placental Lipid Synthetic Pathways Are Impaired By Maternal Insulin Resistance
Luciana Lassance, Ph.D.
2:45 p.m. – 3:00 p.m. Estradiol-17[beta] Stimulates Hydrogen Sulfide Biosynthesis Via Estrogen Receptor (ER[alpha]/[beta])[ndash]Dependent Mechanism in Uterine Artery Smooth Muscle Cells
Thomas J. Lechuga, B.S.
3:00 p.m. – 3:15 p.m. Enhanced Angiotensin Type 2 Receptor-Mediated Vasodilation and Blood Flow in Uterine Arteries of Pregnant Rats
Jay Mishra, Ph.D.
3:15 p.m. – 3:30 p.m. Protection From Endotoxin-Induced Hypotension in Pregnancy: Attenuation By CCR2 Deficiency or Pharmacological Inhibition
Laura Howe, MRes
3:30 p.m. – 3:45 p.m. Progestins Impair Anti-Viral Host Defense
Alicia M. McCarthy, M.D., Ph.D.

Parturition I: Cervix, Myometrium, and Membranes
Moderators: Mala Mahendroo, Ph.D.
                     Xuesen Dong, M.D., Ph.D.

Continental 4
1:45 p.m. – 2:00 p.m. Mouse Myometrial Transcriptome Analysis By RNAseq Shows Inflammation Is a Side-Effect, Not a Requisite, for Labor
Roberta Migale, M.Sc.
2:00 p.m. – 2:15 p.m. Mechanisms Behind a Novel Tocolytic: Blockade of ANOCTAMIN-1 Inhibits Uterine Contractions By Altering Uterine Smooth Muscle Cell Membrane Potential and Thus Intracellular Calcium Levels
Joy Vink, M.D.
2:15 p.m. – 2:30 p.m. Elucidating the Role of miR-143 and miR-145 in Cervical Remodeling and Preterm Birth
Lauren Anton, Ph.D.
2:30 p.m. – 2:45 p.m. Key Determinants of Fetal Fibronectin Extra Domain-A (EDA)-Induced Activation of TLR4
Yoshitsugu Chigusa, M.D., Ph.D.
2:45 p.m. – 3:00 p.m. Oxytocin Modulates a Unique Set of Human Myometrial MicroRNAs
Joanna R.Cook, M.D., MRCOG
3:00 p.m. – 3:15 p.m. Retosiban (GSK221149) [ndash] An Orally Active Oxytocin Receptor Antagonist, Prevents Stretch-Induced Stimulation of Human Myometrial Contractility
Alex Moraitis, M.D.
3:15 p.m. – 3:30 p.m. Histone Modifying Enzymes Involved in the Epigenetic Regulation of Labor-Associated Genes in the Amnion
Tamas Zakar, M.D., Ph.D.
3:30 p.m. – 3:45 p.m. Progesterone Inhibits a Critical Pathway for Fetal Membrane Weakening, In Vitro
D. Kumar, M.D.
Preeclampsia I
Moderators: Robert Powers, Ph.D.
                     Jenny Myers, Ph.D.
Continental 5 – 6
1:45 p.m. – 2:00 p.m. Large Cohort Microarray Analysis Reveals Subclasses of Common Pregnancy Pathologies With Correlation To Clinical Presentations and Outcomes
Brian J. Cox
2:00 p.m. – 2:15 p.m. Poor Placental Vascularization at 12 Weeks of Pregnancy Is Associated With a Specific Cluster of Serum Proteins
Roel de Heus, M.D., Ph.D.
2:15 p.m. – 2:30 p.m. The Role of Aryl Hydrocarbon Receptor Activation in Fetoplacental Endothelial Cell Function and Fetal Growth Restriction
Anna Palatnik, M.D.
2:30 p.m. – 2:45 p.m. The Role of Ca2+ Activated Potassium (KCa) Channels in Enhanced Ca2+ Signaling in Uterine Artery Endothelial Cells (UAEC)
Roxanne E. Alvarez, B.S.
2:45 p.m. – 3:00 p.m. Multiple Cytokines and Growth Factors Associated With Preeclampsia Induce Endothelial Dysfunction in HUVECs Via Src Kinase
Nauman Khurshid, M.D.
3:00 p.m. – 3:15 p.m. Activating Transcription Factor 3 Is Reduced in Preeclampsia and Negatively Regulates sFlt1 and Soluble Endoglin
Tu’uhevaha Kaitu’u-Lino, Ph.D.
3:15 p.m. – 3:30 p.m. Low-Dose Aspirin Reduces the Incidence of Preeclampsia in Women With Multiple Gestations and Elevated Human Chorionic Gonadotropin
Anna G. Euser, M.D., Ph.D.
3:30 p.m. – 3:45 p.m. Antiphospholipid Antibody-Induced miR-146a Activates TLR8 in Trophoblast and Is Inhibited By Vitamin D
Stefan M. Gysler, B.S.
Reproductive Endocrinology and Infertility
Moderators: Esther Eisenberg, M.D., MPH
                     Nataki C. Douglas, M.D., Ph.D.
                     Karen Berkowitz, M.D.
Imperial B
1:45 p.m. – 2:00 p.m. Distinctive Pattern of miRNAs -200b and -429 Expression in Human Ovulation
Tal Imbar, M.D.
2:00 p.m. – 2:15 p.m. Knockout of AIRE (Autoimmune Regulator) Gene Causes Peri-Implantation Fetal Loss and Rapid Reduction in the Ovarian Follicular Reserve
Lynda K. McGinnis, Ph.D.
2:15 p.m. – 2:30 p.m. The Effect of Pyrroloquinoline Quinone on Meiotic Progression in Aged Mouse Oocytes Fed a Control and High Fat Diet
Violet Klenov, M.D.
2:30 p.m. – 2:45 p.m. The Rate of Serum AMH Decline During Controlled Ovarian Hyperstimulation Is Predictive of IVF Response and Clinical Pregnancy
Aaron K. Styer, M.D.
2:45 p.m. – 3:00 p.m. Altered Local Immune Response in the Granulosa Cells of Women With Polycystic Ovarian Syndrome
Jaye Adams, M.D.
3:00 p.m. – 3:15 p.m. Vitamin D Supplementation Increases Serum Levels of Soluble Receptor for Advanced Glycation End Products Among Women With Polycystic Ovary Syndrome
Abdulrahim Rouzi, M.D., FRCSC
3:15 p.m. – 3:30 p.m. Antioxidants Normalize Obesity-Induced Changes in Gene Expression in Granulosa Cells
Monica Mainigi, M.D.
3:30 p.m. – 3:45 p.m. The Weight Is Over: The Impact of Obesity on Antim[uuml]llerian Hormone (AMH) in Young African American Women (AAW)
Lia A. Bernardi, M.D.
3:45 p.m. - 4:00 p.m. Coffee Break Continental Foyer
4:00 p.m. - 6:00 p.m. Mini Symposia I
Views of the Basic Immune Biology of Pregnancy: Past, Present and Future
Moderator: Elizabeth Bonney, M.D.
Continental 5 - 6
4:00 p.m. – 4:30 p.m. What Part of Pregnancy is Immunologically Dangerous?
Polly Matzinger, Ph.D.
4:30 p.m. – 5:00 p.m. Treg Cells at Implantation – MicroRNAs and Other Determinants
Sarah Robertson, Ph.D.
5:00 p.m. – 5:30 p.m. Functional Studies of the Microbiota in Health and Diseases of the Female Urogenital Mucus
Amanda Lewis, Ph.D.
5:30 p.m. – 6:00 p.m. Animal Models of Maternal and Neonatal Immunity
Elizabeth Bonney, M.D.
Impact of Placental Packages on the Maternal Immune System
Moderator: Virginia Winn, M.D., Ph.D.
Continental 1 - 3
4:00 p.m. – 4:30 p.m. Biology of Extracellular Vesicles (Exosomes) in the Immune System
Adrian Morelli, M.D., Ph.D.
4:30 p.m. – 5:00 p.m. Novel Approaches for Analysis of Pregnancy-Related Extracellular Vesicles
Rebecca Dragovic, Ph.D.
5:00 p.m. – 5:30 p.m. Exploring the Role of Placental Exosomes in RA Amelioration
Virginia Winn, M.D., Ph.D.
5:30 p.m. – 6:00 p.m. Vesicle-Based miRNA Communication Among the Placental-Maternal-Fetal Compartments
Yoel Sadovsky, M.D.
Understanding Prenatal Brain Injury: Advances in Diagnosis and Treatment
Moderator: Irina Burd, M.D., Ph.D.
Continental 7 - 9
4:00 p.m. – 4:30 p.m. Understanding Prenatal Brain Injury: Lessons From Animal Models
Irina Burd, M.D., Ph.D.
4:30 p.m. – 5:00 p.m. Mechanisms of Inflammation at the Maternal-Fetal Interface
Vikki Abrahams, Ph.D.
5:00 p.m. – 5:30 p.m. Cell-Based Therapies for Prenatal White Matter Injury?
Michael Johnston, M.D.
5:30 p.m. – 6:00 p.m. Molecular Imaging and Nanotechnology to Prevent CP Caused by IAI
Roberto Romero, M.D., D.Med.Sci.
Endometriosis: Revolutions in an Evolutionary Disease
Moderator: Matt Dyson, Ph.D.
Continental 4
4:00 p.m. – 4:30 p.m. Role of Bone Marrow-Derived Stem Cells in Endometrial Regeneration / Endometriosis
Hugh Taylor, M.D.
4:30 p.m. – 5:00 p.m. An Epigenetic GATA Switch Causes Pathological Gene Expression in Endometriosis
Matt Dyson, Ph.D.
5:00 p.m. – 5:30 p.m. A Non-Human Primate model of Endometriosis
Ov Slayden, Ph.D.
5:30 p.m. – 6:00 p.m. Mechanism-Based Stratification of Endometriosis Patients
Linda Griffith, Ph.D.
Advances in Fertility Preservation: From Now to Next
Moderator: Francesca Duncan, Ph.D.
Imperial A
4:00 p.m. – 4:30 p.m. Ovarian Stem Cells: Their Existence and Potential Roles in Infertility Preservation Treatments
Evelyn Telfer, Ph.D.
4:30 p.m. – 5:00 p.m. Non-Human Primate Model of Ovarian Cortical Tissue Vitrification and Transplantation for Fertility Preservation
Mary Zelinski, Ph.D.
5:00 p.m. – 5:30 p.m. Exploring and Expanding Reproductive Options Through in Vitro Follicle Growth Technologies
Francesca Duncan, Ph.D.
5:30 p.m. – 6:00 p.m. Fertility Preservation: A Clinician’s Perspective
Mary Ellen Pavone, M.D.
Digging Deep: Tumor Immunity, Genetics and Genomics Converge in Gynecological Malignancies
Moderator: Kunle Odunsi, M.D., Ph.D.
Imperial B
4:00 p.m. – 4:30 p.m. Crosstalk Between Cancer Cells and Adipocytes
Ernst Lengyel, M.D., Ph.D.
4:30 p.m. – 5:00 p.m. A Novel CD4+ Th Subset Directly Recognizes Tumor in a Non-Classical Fashion: Implications for Ovarian Cancer Immunotherapy
Kunle Odunsi, M.D
5:00 p.m. – 5:30 p.m. Lineage Dependence as a Target for Therapy in High Grade Serous Ovarian Cancer
Kevin Elias, M.D.
5:30 p.m. – 6:00 p.m. Targeting FANCD2 as a Novel Strategy for Treatment of Ovarian Cancer
Tanja Pejovic, M.D., Ph.D.
Unintended Pregnancy: Scope of Problem, Outcomes and Interventions
Moderator: Alicia Armstrong, M.D.
Franciscan A & B
4:00 p.m. – 4:30 p.m. Scope of Problem
Sunni Mumford, Ph.D.
4:30 p.m. – 5:00 p.m. Obstetric Outcomes After Unintended Pregnancies
Allison Bryant, M.D., MPH
5:00 p.m. – 5:30 p.m. Interventions
Alicia Armstrong, M.D.
5:30 p.m. – 6:00 p.m. Recent Advances in Contraceptive Research
David Archer, M.D.
6:00 p.m. - 7:30 p.m. Connection Corners
New and Mid-Career Investigators come, meet and 'connect' with Senior Investigators about jobs, career advice or just for some friendly banter. Drinks and light appetizers are provided.
Yosemite A & B
Friday, March 27, 2015
6:45 a.m. - 7:45 a.m.

Bayer Breakfast Series II: Abnormal Uterine Bleeding (AUB): Does Mechanistic Insight Offer New Targets for Treatment?

Hilary OD Critchley, M.D.
Professor of Reproductive Medicine
MRC Centre for Reproductive Health
University of Edinburgh
The Queen's Medical Research Institute

Imperial A
7:00 a.m. - 8:00 a.m. Minority Career Development Session
Erica Marsh, M.D., Northwestern University
Ramkumar Menon, Ph.D., University of Texas Medical Branch
Yosemite A & B
8:00 a.m. - 9:00 a.m. Presidents Distinguished Lecture II
Autoimmune-Mediated Infertility: Reconsidering Immune Tolerance to Self
Margaret G. Petroff, Ph.D.
Associate Professor, Department of Pathobiology and Diagnostic Investigation
College of Veterinary Medicine
Michigan State University
East Lansing, Michigan
Continental 5 - 6
9:00 a.m. - 11:00 a.m. Poster Session II Grand Ballroom A & B
11:00 a.m. - 12:30 p.m. Concurrent Oral Presentations II
Developmental Programming I
Moderators: Kent L.R. Thornburg, Ph.D.
                    Alison Holloway, Ph.D.
Continental 5 - 6
11:00 am. – 11:15 a.m. Maternal Obesity Programs a Metabolic Syndrome Phenotype in Rat Offspring That Is Ameliorated By Exercise Even in Old Age: It’s Never Too Late
Consuelo Lomas, Ph.D.
11:15 a.m. – 11:30 a.m. Markers of Insulin Resistance and Mitochondrial Overload in Young, Low Birth Weight, Male Guinea Pig Offspring
Kristyn Dunlop, B.S.
11:30 a.m. – 11:45 a.m. Perinatal Growth Restriction-Induced Cardiac Remodeling
Vani C. Movva, MBBS
11:45 a.m. – 12:00 p.m. Antenatal Glucocorticoids Lead To Multigenerational Programming of Behaviour Via Paternal Transmission
Vasilis G. Moisiadis, B.Sc.
12:00 p.m. – 12:15 p.m. Antioxidants Reverse Obesity-Induced Transcriptomic Changes in Oocytes
Kathleen O’Neill, M.D.
12:15 p.m. – 12:30 p.m. Exposure To Grandmaternal Low-Protein Diet Gives Rise To Accelerated Reproductive Aging
Catherine E. Aiken, M.D., Ph.D.
Gynecology Oncology
Moderators: Bo Rueda, Ph.D.
                     Thangesweran Ayakanu, MRCOG, MBBS, DRCOG
Continental 1 - 3
11:00 a.m. – 11:15 a.m. Gene Signature of PTEN]mutant DICER+/- Endometrial Cancer Predicts Worse Survival
Shannon M. Hawkins, M.D., Ph.D.
11:15 a.m. – 11:30 a.m. Bazodoxifene Reduces FGF18 Expression in Human Endometrial Stromal Cells In Vitro and in Mice through an Increase in HAND2 Expression
Clare A. Flannery, MD.
11:30 a.m. – 11:45 a.m. Transferrin Facilitates DNA-Double Strand Breaks Via Transferrin Receptor 1 in Human Fallopian Tubal Epithelial Cells: Possible Involvement of Transferrin in Carcinogenesis
Shogo Shigeta, M.D.
11:45 a.m. – 12:00 p.m. Cantrixil Induces JNK-Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents In Vivo Recurrence
Ayesha B. Alvero, M.D., M.Sc.
12:00 p.m. – 12:15 p.m. Chemoresistance in Epithelial Ovarian Cancer Cells Is Controlled By Mechanisms Emanating From Chemotherapy-Induced Genotype Switch in Glutathione Peroxidase, Through the Up-Regulation of Cytidine Deaminase
Nicole M. Fletcher, Ph.D.
12:15 p.m. – 12:30 p.m. Mutations in the PIK3 Pathway as a Major Determinant of Trastuzumab Resistance in Uterine Serous Carcinoma
Jonathan Black, M.D., M.Sc.
Placenta I
Moderators: Tereza Cindrova-Davies, Ph.D.
                     Stacy Zamudio, Ph.D.
Imperial A
11:00 a.m. – 11:15 a.m. Placental Homing Peptide-microRNA-145 Inhibitor Conjugates for Targeted Enhancement of Placenta Growth
Lynda K. Harris, Ph.D.
11:15 a.m. – 11:30 a.m. Role of Irisin in Modulation of Human Trophoblast Differentiation
Hamid Reza Kohan-Ghadr, Ph.D.
11:30 a.m. – 11:45 a.m. Secreted Frizzled Related Protein 1 (sFRP1) May Impair Wnt Signaling To Lead To Fetal Growth Restriction
Alice M. Wang, M.D.
11:45 a.m. – 12:00 p.m. Alterations To DNA Methylation and Hydroxymethylation in Placenta With Maternal Adiposity
Kohzoh Mitsuya, Ph.D.
12:00 p.m. – 12:15 p.m. Multiplexed Genotyping and Concurrent Allele-Specific Expression Analysis for Imprinted Gene Verification in Human Placenta
Jill L. Reiter, Ph.D.
12:15 p.m. – 12:30 p.m. A Mouse Model of Advance Maternal Age - Understanding Older Mothers’ Vulnerability To Late Stillbirth
Samantha C. Lean, B.Sc. (Hons), MRes
Pre-Clinical Perinatology Research Models
Moderators: Ronald R. Magness, Ph.D.
                    Asgerally Faxleabas, Ph.D.
Imperial B
11:00 a.m. – 11:15 a.m. Increased Nitrotyrosine (NT) Expression in the Pancreas of IUGR Fetal Baboons in Late Gestation Indicates That Fetal Nutrient Restriction Promotes Inflammatory Responses and Oxidative Stress (OS) in the Developing Primate Pancreas
Ablat Tursun, Ph.D.
11:15 a.m. – 11:30 a.m. Maternal Western-Style Diet Diminishes Placental Perfusion in a Non-Human Primate Model
Jamie Lo, M.D.
11:30 a.m. – 11:45 a.m. Maternal Antioxidant Treatment Increases Expression of Genes Regulating Hypoxia Signalling, Sodium Movement and Surfactant Maturation in the Fetal Lung
E.V. McGillick, Ph.D.
11:45 a.m. – 12:00 p.m. Specific DAMPs Cause Sterile Inflammation of the Chorioamniotic Membranes and Adverse Perinatal Outcomes
Olesya Plazyo, M.Sc.
12:00 p.m. – 12:15 p.m. Reduced Glycolytic Pathway in the Placenta With Maternal Obesity
Alina Maloyan, Ph.D.
12:15 p.m. – 12:30 p.m. Dietary-Induced Obesity Suppresses Expression and Alters Rhythmicity of Clock Genes in Maternal Metabolic Tissues During Rat Gestation
Rachael C. Crew, B.S.
Reproductive Biology I
Moderators: Ov D. Slayden, Ph.D.
                     Sarah A. Marshall, M.Sc.
Continental 4
11:00 a.m. – 11:15 a.m. Human Endometrial Stromal Cell Connexin (Cx)43 Responds Reversibly To Hormone Stimulation and Withdrawal and Regulates Markers of Angiogenesis and Mesenchymal-Epithelial Transition (MET)
Robert N. Taylor, M.D., Ph.D.
11:15 a.m. – 11:30 a.m. Differences in Phenotypic Features and Hormone Responsiveness Between Healthy Uterine Endometrium and Matched Tubal Epithelium in Women
Eve Bunni, M.Phil.
11:30 a.m. – 11:45 a.m. Epigenetic Therapy: Novel Translational Implications for Arrest of Environmental Dioxin Induced Endometriotic Progression
Zaraq Khan, MBBS
11:45 a.m. – 12:00 p.m. The miR-200 Family Regulates Mesenchymal-Epithelial Transition in Human Endometrial Stromal Cells During Decidualization
Patricia T. Jimenez, M.D.
12:00 p.m. – 12:15 p.m. PER2 Synchronizes Mitotic Transition and Decidual Transformation of Human Endometrial Stromal Cells
Joanne Muter, M.Sc.
12:15 p.m. – 12:30 p.m. Expression and Regulation of the Cysteine-Rich Secretory Proteins CRISPs in the Non-Human Primate Reproductive Tract
Carol B. Hanna, Ph.D.
Stem Cells
Moderator: Carlos Simon, M.D., Ph.D.
                    Levent Mutlu, M.D.
Continental 7 - 9
11:00 a.m. – 11:15 a.m. Bone Marrow-Derived Cells in Murine Endometrium Express Estrogen Receptor Beta
Sara S. Morelli, M.D.
11:15 a.m. – 11:30 a.m. CD146 and CD140b Enrich for Putative Stem/Progenitor Cells in Human Myometrium and Fibroids
Amanda L. Patterson, Ph.D.
11:30 a.m. – 11:45 a.m. Spontaneous Single-Copy Deletion of chr17p13.1 in Human Embryonic Stem Cells Improves Cell Survival By Decreasing Expression of TP53
Hadar Amir, M.D., Ph.D.
11:45 a.m. – 12:00 p.m. Decellularization of the Rat Uterus Yielded Scaffold Capable of Tissue Regeneration Without Immune Rejection Upon Allotransplantation
Kaoru Miyazaki, M.D., Ph.D.
12:00 p.m. – 12:15 p.m. Premature Ovarian Insufficiency (POI) Is Associated With Abnormalities in Ovarian Stem Cells (OSC) in an Allogeneic Non-Human Primate (NHP) Transplant Model
Jaclyn Yu, B.S.
12:15 p.m. – 12:30 p.m. 17beta-Estradiol Enhanced CXCL12/CXCR4 Expression Mediates Bone Marrow-Derived Stem Cell Migration To Human Endometrium
Xiuli Wang, M.D.
12:45 p.m. - 2:00 p.m.

Toolbox Symposium

Advances in Gene Editing: Using CRISPR and TALENs in the Development of Non-human Primate Disease Models
Jon D. Hennebold, Ph.D.
Oregon National Primate Research Center
Oregon Health & Science University
Beaverton, Oregon

Development in FACS - The Latest in Cell Sorting, Analysis, and Reagents
Rebecca LaFond, Ph.D.
Miltenyi Biotec

Continental 5 - 6
12:45 p.m. - 2:00 p.m. SRI President's Presenter Awards (By invitation only) Franciscan A & B
2:00 p.m. - 4:00 p.m. Mini Symposia II

Understanding Aging and Age-Induced Impairment in Oocyte Quality
In honor of Dr. Robert Jaffe's outstanding contributions to the field of Reproductive Medicine.
Moderator: Margareta Pisarska

Ovarian Aging: From DOR to POF - Pathways of Ovarian Dysfunction
Margareta Pisarska, M.D.

DNA Repair - An Important Determinant of Oocyte Aging
Kutluk Oktay, M.D.

Mitochondrial Dysfunction and Ovarian Aging
Andrea Jurisicova, Ph.D.

Exomes, Chromosomes and Ovarian Failure
Aleksandar Rajkovic, M.D., Ph.D.

Pelvic Organ Prolapse: Recent Insights and New Treatments
Moderator: Caroline Gargett

The Genetic Epidemiology of Pelvic Organ Prolapse
Jennifer Wu, M.D., MPH

Inflammaging and Pelvic Support: Is There a Fountain of Youth for the Pelvic Floor?
Kathleen Connell, M.D.

Elastogenesis and Role of Estrogen in Pelvic Organ Prolapse
R Ann Word, Ph.D.

Endometrial Mesenchymal Stem Cells as Cell-Based Therapy for POP
Caroline Gargett, Ph.D.

Recent Advances in Leiomyoma Therapy: From Conception to Application
Moderator: William Catherino

Evolution of Robotic Surgical Management of Uterine Leiomyomas
William Catherino, M.D., Ph.D.

Non-Surgical Procedural Leiomyoma Therapies
Ebbie Stewart, M.D.

Origins, Advances and Controversies in Hysteroscopic Myomectomy
Erica Marsh, M.D.

Medical Management of Leiomyomas: From Bench to Bedside
Kristof Chwalisz, M.D., Ph.D.

Immunity and Inflammation in Disease of the Fetus, Neonate and Child
Moderator: Kristina Adams Waldorf, M.D.

Molecular Mechanisms Linking Placental Infection, Inflammation and Fetal Injury
Kristina Adams Waldorf, M.D.

Red Blood Cell Alloimmunization During Pregnancy: a First Look at Mechanisms, Consequences and Potential Therapeutics
Jeanne Hendrickson, M.D.

Placental Responses Mediate Adverse Effects of Maternal Immune Activation on Neurodevelopment
Elaine Hsiao, Ph.D.

Gestational Gene-Immune Interactions in Neurodevelopmental Disorders
Theo Palmer, Ph.D.

Pregnancy Programming and Implications for Long-Term Health
Moderator: Jane Norman, M.D.

Developmental Programming - Does it Really Exist? Evidence From Human Studies
Jane Norman, M.D.

Placental Nutrient Sensing, Fetal Growth and Later Disease
Thomas Jansson, M.D., Ph.D.

Programming by Maternal Over-Nutrition - a Developing Obesity Crisis
Susan Ozanne, Ph.D.

Maternal Stress, Placental O-GlcNAc Transferase, and Neurodevelopmental Disorders
Tracy Bale, Ph.D.

Trophoblast Over-Invasion: The Rise of Placenta Accreta
Moderator: Nicholas Illsley, Ph.D.

Placenta Accreta: “The New Epidemic”
Abdulla Al-Khan, M.D.

Abnormal Vascular Architecture at the Placental-Maternal Interface in Abnormally Invasive Placenta
Frederic Chantraine, M.D.

Role in Decidua in Regulating Trophoblast Invasion and Differentiation
Judith Bulmer, Ph.D.

Ultrasound Techniques for Quantification of Severity of Abnormally Invasive Placenta
Sally Collins, M.D.

Clues to the Molecular Etiology of Placenta Accreta
Nick Illsley, Ph.D.

4:00 p.m. - 4:15 p.m. Coffee Break Continental Foyer
4:15 p.m. - 5:45 p.m. Concurrent Oral Presentations III
Fetus I
Moderators: Lubo Zhang, Ph.D.
                     Stephanie Baello, Ph.D.
Continental 1 - 3
4:15 p.m. - 4:30 p.m. Chronic Fetal Hypoxia in Ovine Pregnancy Triggers a Fetal Origin of Heart Disease That Amplifies With Ageing: Prevention With Maternal Antioxidant Treatment
E. J. Camm, Ph.D.
4:30 p.m. - 4:45 p.m. Blockade of T[sub]3[/sub] Reveals the Maturation of p21 Signaling in Fetal Cardiomyocytes
N. N. Chattergoon, Ph.D.
4:45 p.m. - 5:00 p.m. Role of Catecholamines in Maternal-Fetal Stress Transfer
Florian Rakers, M.D.
5:00 p.m. - 5:15 p.m. Fetal NK Cells Contribute To Late-Gestation Fetal Fitness
Beverly Strong, Ph.D.
5:15 p.m. - 5:30 p.m. Altered DNA Methylation and Gene Expression of the IGF Axis in Pregnancies Affected By Fetal Growth Disorders
Aamod Nawathe, MRCOG
5:30 p.m. - 5:45 p.m. Inadequate Maternal Acquisition of Immune Tolerance During Pregnancy Leads To Trans-Generational IUGR
Daniel A. Kahn, M.D., Ph.D.
Gynecology II: Fibroids
Moderators: James H. Segars
                     Shannon Hawkins, M.D., Ph.D.
Imperial B
4:15 p.m. - 4:30 p.m. Targeted Adenoviral Vector Demonstrates Enhanced Efficacy and Safety for In Vivo Gene Therapy of Uterine Leiomyoma
Mohamed Abdelaziz, M.D.
4:30 p.m. - 4:45 p.m. Progesterone Dependent Paracrine Activation of RANKL/RANK Signaling in Human Uterine Leiomyoma Stem/Progenitor Cells Drives Tumor Growth
Ping Yin, M.D., Ph.D.
4:45 p.m. - 5:00 p.m. Inhibition of MicroRNA 29c Expression in Leiomyomas Leads To Up-Regulation of Extracellular Matrix Proteins and DNA Methyltransferase
Omid Khorram, M.D., Ph.D.
5:00 p.m. - 5:15 p.m. Ulipristal Acetate Inhibits Extracellular Matrix Production in Human Leiomyomas In Vivo: A Laboratory Analysis of a Randomized Controlled Trial
Jeris Cox, M.D.
5:15 p.m. - 5:30 p.m. Pharmacodynamic Effects and Safety of the Novel Selective Progesterone Receptor Modulator Vilaprisan in Healthy Women
Beate Rohde, M.D., Ph.D.
5:30 p.m. - 5:45 p.m. Is There a Relationship Between the Presence of Fibroids and Antimullerian Hormone (AMH) Concentrations in Young African American Women (AAW)?
Deboarah E. Ikhena, M.D.
Parturition II: Infection and Microbiome
Moderators: Sarah K. England, Ph.D.
Jeyasuria Pancharatnam, Ph.D.
Continental 5 - 6
4:15 p.m. - 4:30 p.m. The Immunoproteasome: A Novel Therapeutic Target for Spontaneous Preterm Birth
Stella Liong, Ph.D.
4:30 p.m. - 4:45 p.m. Innate Immune Response To Vaginal Commensals
Amy M. Valent, D.O.
4:45 p.m. - 5:00 p.m. Acute Subclinical Maternal Inflammation in Late Pregnancy
Maide Ozen, M.D.
5:00 p.m. - 5:15 p.m. Maternal Malnutrition Impacts the Holobiome and Gut Transporters
K. L. Connor, Ph.D.
5:15 p.m. - 5:30 p.m. Oral Lactobacillus rhamnosus GR-1 L. reuteri RC-14 Does Not Change the Vaginal Microbiota or Cervico-Vaginal Cytokines in Low Risk Pregnant Women With an Abnormal Nugent Score
S. W. Yang, B.S.
5:30 p.m. - 5:45 p.m. Viral dsRNA Augments Fetal Membrane Inflammatory Responses To Bacterial LPS By Disabling the TAM Receptor Pathway
Sarah N. Cross, M.D.
Placenta II: Invasion/Angiogenesis
Moderators: Margaret G. Petroff, Ph.D.
                     Sascha Drewlo, Ph.D.
Continental 7 - 9
4:15 p.m. - 4:30 p.m. Low Molecular Weight Heparin Advances Extravillous Differentiation and Inhibits Cell Death in Human Trophoblast Cells Through HBEGF/ERBB Signaling
Alan D. Bolnick, M.D.
4:30 p.m. - 4:45 p.m. HLA-G Induces Human Trophoblast Migration By Interacting With the Ras Effector RIN1
Ji-meng Wang, M.D.
4:45 p.m. - 5:00 p.m. Impaired Fetoplacental Angiogenesis in Pregnancies Complicated By Severe Fetal Growth Restriction and Abnormal Umbilical Artery Doppler Velocimetry Is Ameliorated By Rescuing Expression of Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT)
Emily J. Su, M.D., M.Sc.
5:00 p.m. - 5:15 p.m. Energy Status and HIF Signaling in Chorionic Villi Show No Evidence of Hypoxic Stress During Human Early Placental Development
Tereza Cindrova-Davies, Ph.D
5:15 p.m. - 5:30 p.m. Type I Interferons Change the Function of 1st To 2nd Trimester Uterine Natural Killer Cells: Consequences for Trophoblast Invasion and Endothelial Network Formation
Emiel D. Post Uiterweer, M.D.
5:30 p.m. - 5:45 p.m. Maternal Adiposity Alters Placental BDNF Expression and TRKB Phosphorylation
Calais S. Prince, B.S.
Preeclampsia II
Moderators: Louise C. Kenny, Ph.D., MRCOG
                     Aruh Jeyabalan, M.D.
Continental 4
4:15 p.m. - 4:30 p.m. Pravastatin Quenches Preeclampsia in Humans: A Potential Therapeutic
Fiona Brownfoot, MBBS
4:30 p.m. - 4:45 p.m. 4-Methoxyestradiol Induces Proliferation Through a Gxi Protein Coupled Receptor-Dependent Mechanism in Uterine Artery Endothelial Cells Derived From Pregnant Ewes
Rosalina Villalon Landeros, B.S.
4:45 p.m. - 5:00 p.m. Salivary Uric Acid Levels in Women Destined To Develop Preeclampsia: Longitudinal Prospective Study
Bas B. van Rijn, M.D., Ph.D.
5:00 p.m. - 5:15 p.m. Increasing the Arginine/ADMA Ratio By Citrulline Administration at 16-20 Weeks Gestation Decreases Blood Pressure and sFLT1, and Increases PlGF at 35 Weeks in Obese Pregnant Women
Robert W. Powers, Ph.D.
5:15 p.m. - 5:30 p.m. Hydrogen Sulphide Rescues Preeclampsia-Like Phenotype Aggravated By High sFlt-1 in Placenta Growth Factor (PlGF) Deficiency
Shakil Ahmad, Ph.D.
5:30 p.m. - 5:45 p.m. Decreased Plasma Hemopexin Activity Is Associated With Increased Placental and Monocyte AT-1 Receptor Expression and Lower Plasma Levels of the AT-1 Receptor in Preeclampsia
Floor Spaans, Ph.D.

Reproductive Biology II
Moderators: Dharani Hapangama, MBChB, M.D., MRCOG
                     Emre Seli, M.D.

Imperial A
4:15 p.m. - 4:30 p.m. Mannose-Binding Lectin (MBL) and Interferon Gamma (IFNg) Gene Polymorphisms Influence Susceptibility To Blocked Fallopian Tubes
Joseph Chervenak
4:30 p.m. - 4:45 p.m. Hydrosalpinx Is Associated With Reduced Ovarian Reserve
Shannon Renfrow, M.D.
4:45 p.m. - 5:00 p.m. MCP-1: An Inflammatory Marker That Affects Ovarian Follicular Development in Mice
Zaher Merhi, M.D.
5:00 p.m. - 5:15 p.m. Improvement of Corpus Luteum Function in Obese Women Is Associated With Reduced Pro-Inflammatory Cytokines After Exogenous Estradiol Treatment
Zain A. Al-Safi, M.D.
5:15 p.m. - 5:30 p.m. Analysis of Nanosorted Oocyte Mitochondrial Subpopulations Reveals Active But Reversible Repression of Non-Respiring Mitochondria
Kshama Chandrasekhar, Ph.D.
5:30 p.m. - 5:45 p.m. Antiphospholipid Antibody-Induced Trophoblast miR-146a and IL-8 Is Regulated By the TAM Receptor Ligand Gas6
Vikki M. Abrahams, Ph.D.
6:00 p.m. - 6:45 p.m. SRI Business Meeting (Members only) Continental 5 - 6
6:45 p.m. - 7:15 p.m. Wine and Cheese Reception Continental Foyer
7:15 p.m. - 8:00 p.m. New Investigator Awards Ceremony Continental 5 - 6
Saturday, March 28
6:45 a.m. - 7:45 a.m.

Bayer Breakfast Series III: Endometriosis in 2015: Modern Management.

Charles Chapron, M.D.
Professor and Chair, Obstetrics, Gynecology and Reproductive Medicine, CHU Cochin, Paris France
Vice Dean of Paris Descartes University

Imperial A
7:45 a.m. - 9:45 a.m. Poster Session III Grand Ballroom A & B
8:00 a.m. - 1:00 p.m. Registration Yosemite Foyer
10:00 a.m. - 11:30 a.m. Presidential Address, Awards Ceremony, SRI-Pardi Distinguished Scientist Award and Lecture
10:00 a.m. - 10:30 a.m. Presidential Address
10:30 a.m. - 10:45 a.m. Awards Ceremony President's Achievement Award
Frederick Naftolin Award for Mentorship
Rogerio A Lobo Award
10:45 a.m. - 11:30 a.m. SRI - Pardi Distinguished Scientist Award and Lecture
Fifty Years After Huxley: The Roadmap of Reproductive Medicine Revisited and Updated
Eli Y. Adashi, M.D., M.S., CPE, FACOG
Professor of Medical Science and of Obstetrics and Gynecology
Former Dean of Medicine and Biological Sciences
The Warren Alpert Medical School Brown University
Continental 5 – 6
11:30 a.m. - 12:00 p.m. Lunch Break (boxed lunch provided) Continental Foyer
12:00 p.m. - 1:00 p.m. Hot Topics Continental 5 - 6
1:15 p.m. - 2:45 p.m. Concurrent Oral Presentations IV
Developmental Programming II
Moderators: Antonio E. Frias, M.D.
                      Thomas Jansson, M.D., Ph.D.
Imperial A
1:15 p.m. - 1:30 p.m. Prenatal Hypoxia Reduces In Vivo Cardiac Function in Offspring Guinea Pigs
Loren P. Thompson, Ph.D.
1:30 p.m. - 1:45 p.m. Xanthine Oxidase (XO) Inhibition as Therapy for the Interaction Between Developmental Hypoxia and Ageing in Promoting Cardiovascular Disease Risk
B. J. Allison, Ph.D.
1:45 p.m. - 2:00 p.m. Accelerated Aging of Cardiac Function in Offspring of Undernourished Pregnant Baboons
Peter W. Nathanielsz, M.D., Ph.D.
2:00 p.m. - 2:15 p.m. Conjugated Linoleic Acid Supplementation Ameliorates Maternal Obesity-Induced Programming of Metabolic Dysfunction in Male Rat Offspring
Stephanie A. Segovia, B.S.
2:15 p.m. - 2:30 p.m. Gestational Protein Restriction Causes Hyperglycemia By Affecting IRS-1 Tyrosine Phosphorylation and the Dysregulation of Akt-GSK3 Signaling in Adult Female Offspring
Chellakkan S. Blesson, Ph.D., M.Sc.
2:30 p.m. - 2:45 p.m. Sex Differences on the Effects of Antenatally To Glucocorticoids on Insulin Resistance in Lean and Obese Adult Sheep
Jorge P. Figueroa, M.D., Ph.D.
Epidemiology/Population Health/Global Health
Moderators: Deborah Wing, M.D.
Torri Metz, M.D.
Continental 1 - 3
1:15 p.m. - 1:30 p.m. Preterm Neonatal Death and Morbidity By Gestational Age: A Contemporary Cohort
T. Manuck, M.D.
1:30 p.m. - 1:45 p.m. Obstetrical Mode of Delivery and Childhood Mental Illness and Behavior in a British Cohort
Eileen A. Curran, MPH
1:45 p.m. - 2:00 p.m. Maternal Use of Oral Contraceptives and Risk of Birth Defects
Brittany M. Charlton, Sc.D.
2:00 p.m. - 2:15 p.m. The Exposure To Known Hazardous Air Pollutants During Pregnancy Varies Significantly Within a Large Urban Population
Jerasimos Ballas, M.D., MPH
2:15 p.m. - 2:30 p.m. Predictors and Modifying Factors for New Onset Depression During the Menopause Transition: A Large Prospective Cohort Study
Martha Hickey, M.D., Ph.D.
2:30 p.m. - 2:45 p.m. Utilization of Emergency Departments for Care of Menstrual Disorders: Analyses Using the Nationwide Emergency Department Sample (NEDS)
Jamie M. McGuire, M.D., MPH
Fetus II
Moderators: Peta Grigsby, Ph.D.
                     Vladimir E. Vargas, Ph.D.
Continental 7 - 9
1:15 p.m. - 1:30 p.m. Prenatal Glucocorticoid Treatment Matures the Fetal Blood-Brain Barrier(bbb) and Alters Responsiveness To TGF-[beta]1
Stephanie Baello, B.S.
1:30 p.m. - 1:45 p.m. Mouse Model of Intrauterine Inflammation: Role of Maternal Glucose Supplementation
Jun Lei, Ph.D.
1:45 p.m. - 2:00 p.m. Blockade of Steroid Sulfatase Augments Fetal Hypothalamus-Pitutiary-Adrenal Axis Activity in Late Gestation Fetal Sheep
Charles E. Wood, Ph.D.
2:00 p.m. - 2:15 p.m. Placental Estrogen Suppresses Cyclin D1 Expression in the Nonhuman Primate Fetal Adrenal Cortex
Eugene D. Albrecht, Ph.D.
2:15 p.m. - 2:30 p.m. The Effect of Maternal Sildenafil Citrate on the Growth Restricted Fetal Lamb
Charlotte J. Oyston, MB ChB, BMedSci
2:30 p.m. - 2:45 p.m. Targeting Mitochondria-Derived Reactive Oxygen Species (ROS) as Protective Therapy Against Fetal Origins of Cardiovascular Disease
K. L. Skeffington, B.A.

Gynecology III: Endometriosis
Moderators: Robert N. Taylor, M.D., Ph.D.
                     Aaron K. Styer, M.D.

Imperial B
1:15 p.m. - 1:30 p.m. Epigenetically Altered Immune Responses Determine Lesion Morphology and Clinical Presentation in Endometriosis
Abigail A. Delaney, M.D.
1:30 p.m. - 1:45 p.m. Lentiviral Mediated Genetic Manipulation of a Model of Endometriosis
Cynthia Barbara, M.D.
1:45 p.m. - 2:00 p.m. Platelets Are Responsible for Impaired Natural Killer Cell Cytotoxicity in Endometriosis
Sun-Wei Guo, Ph.D.
2:00 p.m. - 2:15 p.m. Altered Protein Expression After Induction of Endometriosis in Baboons Using a Proteomics Approach
Dorien O, M.Sc.
2:15 p.m. - 2:30 p.m. miR451 Is Over-Expressed in Human Endometriotic Implant Tissue and Targets Macrophage Migration Inhibitory Factor To Reduce Cell Survival
Warren B. Nothnick, Ph.D.
2:30 p.m. - 2:45 p.m. Metformin Inhibits CYP19A1 and StAR[ Expression in Human Endometriotic Stromal Cells Via AMPK-Mediated Disruption of CREB-CRTC2 Complex Formation
Qing Xue, M.D., Ph.D.
Parturition III: Hormones and Inflammation
Moderators: Jane E. Norman, M.D.
                     Kristin Connor, Ph.D.
Continental 4
1:15 p.m. - 1:30 p.m. Notch Signaling Is Activated in Inflammation-Induced Preterm Labor and Its Inhibition Reduces the Pro-inflammatory Response
Varkha Agrawal, Ph.D.
1:30 p.m. - 1:45 p.m. ERK1/2 MAPK, But Not COX-2, Mediates Interleukin(IL)-1[beta] Decreased Progesterone Receptor Expression in Decidual Cells: A Potential Signaling Pathway That Triggers Functional Progesterone Withdrawal During Inflammation Induced Preterm Birth
Umit A. Kayisli, Ph.D.
1:45 p.m. - 2:00 p.m. PGF2[alpha] Promotes Uterine Transformation Through Positive Feedback Interactions and Synergy With IL-1[beta] in Human Myometrium Smooth Muscle Cells (HMSMC)
Kelycia B. Leimert, B.Sc.
2:00 p.m. - 2:15 p.m. Progesterone Receptor-A Stability and Repressive Activity Is Increased By Proinflammatory Stimuli in Human Myometrial Cells
Gregory A. Peters, Ph.D.
2:15 p.m. - 2:30 p.m. Preterm Cervical Ripening Is More Complex Than Progesterone Withdrawal
Annika Lindqvist, Ph.D.
2:30 p.m. - 2:45 p.m. Amniotic Fluid Telomere Fragments: Fetal Signals for Parturition?
Faranak Behnia, M.D.
Placenta III
Moderators: Mana Parast, M.D., Ph.D.
                     Lydia K. Lee, M.D., Ph.D.
Continental 5 - 6
1:15 p.m. - 1:30 p.m. Maternal Folate Deficiency Inhibits Placental mTOR Signaling and Amino Acid Transporter Activity and Causes Fetal Growth Restriction in Mice
Frederick J. Rosario, Ph.D.
1:30 p.m. - 1:45 p.m. CGI-58 Is a Key Regulator of Selective Trans-Placental Transfer of Long-Chain Polyunsaturated Fatty Acids (LCPUFA)
Yoel Sadovsky, M.D.
1:45 p.m. - 2:00 p.m. Sodium Selenite Protects Syncytiotrophoblast Mitochondrial Respiration Under Conditions of Maternal Obesity and Oxidative Stress
LaShauna Evans, Ph.D.
2:00 p.m. - 2:15 p.m. Involvement of STAT3 in the Induction of COX-2 Expression By Cortisol in Human Amnion Fibroblasts
Wangsheng Wang, Ph.D.
2:15 p.m. - 2:30 p.m. Placental Macrophages (Hofbauer Cells) Infected With Herpesvirus Activate Human Umbilical Vein Endothelial Cells (HUVECs) Through an IL-1[beta]- Dependent Mechanism
Paul W. Hendrix, D.O.
2:30 p.m. - 2:45 p.m. Alarmins Potently Induce Inflammation in Placental Cells and Impair Trophoblast Turnover
Sylvie Girard, Ph.D.
3:00 p.m. - 3:30 p.m. Best New Investigator Poster Awards
Coffee and snack provided
Continental 5 - 6
3:45 p.m. - 5:15 p.m. SRI Council Meeting (Council Members only) Union Square 1 - 2