New way to halt leukemia relapse shown promising in mice
Drugs tackling chronic myelogenous leukemia have completely transformed prognoses of patients over the last couple of decades, with most cases going into remission. But drug resistance can occur, leading to relapses. Targeting the lipids involved in regulating part of a leukemia stem cell's life span offers a potential second route to defeat the disease -- and solid tumorous cancers as well.
Uncovering the clock that sets the speed of embryo development
Why do pregnancies last longer in some species than others? Researchers have found the clock that sets the speed of embryonic development and discovered the mechanism is based on how proteins are made and dismantled. The study could also help us understand how different mammals evolved from one another and help refine methods for regenerative medicine.
A new discovery in regenerative medicine
Researchers have made an unexpected world-first stem cell discovery that may lead to new treatments for placenta complications during pregnancy.
Next-gen organoids grow and function like real tissues
Bioengineers have created miniature intestines in a dish that match up anatomically and functionally to the real thing better than any other lab-grown tissue models. The biological complexity and longevity of the new organoid technology is an important step towards enabling drug testing, personalized medicine, and perhaps, one day, transplantations.
Generation of three-dimensional heart organoids
Researchers engineered three-dimensional functional heart organoids resembling the developing heart. By exposing mouse embryonic stem cells to two key proteins during heart development, the researchers were able to form heart organoids with structural, functional, and molecular similarities to the embryonic heart during development. This method could be used to study heart development and to screen for novel drugs against heart disease.