Scientists develop 'off the shelf' engineered stem cells to treat aggressive brain cancer
Investigators have devised a novel therapeutic method for treating glioblastomas post-surgery by using stem cells taken from healthy donors engineered to attack GBM-specific tumor cells. This strategy demonstrated profound efficacy in preclinical models of GBM, with 100 percent of mice living over 90 days after treatment.
For large bone injuries, it's Sonic hedgehog to the rescue
A new study presents intriguing evidence that large bone injuries might trigger a repair strategy in adults that recapitulates elements of skeletal formation in utero. Key to this repair strategy is a gene called Sonic hedgehog. In this study, researchers took a close look at how mice are able to regrow large sections of missing rib -- an ability they share with humans, and one of the most impressive examples of bone regeneration in mammals. To their surprise, the scientists observed an increase in the activity of Sonic hedgehog (Shh), which plays an important role in skeletal formation in embryos, but hasn't previously been linked to injury repair in adults.
Great progress thanks to mini organs
Life-like organ replicas -- so-called 3D organoids -- are a good way to research disease processes. A team has now presented a kind of blueprint for such a model of the cervix.
Cardiac progenitor cells generate healthy tissue after a heart attack
Following a heart attack, the human body is incapable of repairing lost tissue due to the heart's inability to generate new muscle. However, treatment with heart progenitor cells could result in the formation of functional heart cells at injured sites. This new therapeutic approach may be tested in clinical studies within the next two years.
Mind the gap: Space inside eggs steers first few steps of life
Imagine sitting at a meeting where the shape of the table and your place at it might impact how you get along with the other members. Cells also communicate with their nearest neighbors, and in embryos, nothing is left to chance in the 'seating plan' for the first few cells. However, questions remain about the how this process is controlled and how it can influence the overall growth of an organism.