SRI65th Annual Scientific Meeting
SRI 65th Annual Scientific Meeting

Society of Reproductive Investigation (SRI)

65th Annual Scientific Meeting, March 6-10, 2018

San Diego

Tuesday, March 6

11:00 a.m - 6:00 p.m.

Registration

SAPPHIRE WEST FOYER

2:00 p.m. - 6:00 p.m

Bayer Sponsored Career Development Workshops

  • Effective Presentation Skills
    Mary E. Wlodek, PhD
    University of Melbourne
  • Grant Writing 101: From idea to Specific Aims
    Thomas Jansson, MD PhD
    University of Colorado
  • Ethics in Science
    David Resnik, JD PhD
    NIH
  • Rules of Collaboration for New Investigators
    Kristina Adams Waldorf, MD
    Chris Haskell - Bayer
    Roberto Romero, MD D.Med.Sci. - NICHD/NIH
    Steven Yellon, PhD - Loma Linda University

*The Career Development Workshops are Non-CME events.

AQUA CD

6:15 p.m. - 7:15 p.m

Mentor in a Cloud Speed Dating & Networking Event
*for those who are part of the Mentorship Program
*wine and cheese will be served during the event

AQUA AB

Wednesday, March 7

7:00 a.m. - 6:00 p.m.

Registration

SAPPHIRE WEST FOYER

7:00 a.m. - 8:15 a.m.

Mid-Career Investigator Breakfast
Collaboration with Investigators in Middle Income Countries,
featuring Brazil, China, Egypt, India, Mexico and Turkey.

COBALT 500

8:30 a.m. - 5:00 p.m.

Endometrium Satellite Meeting

AQUA 300 AB

8:30 a.m. - 5:00 p.m.

Fetal Physiology Satellite Meeting

AQUA AB

8:30 a.m. - 5:00 p.m.

Joint satellite symposium – Preterm Birth International Collaborative
(PREBIC) and Parturition/Myometrium

AQUA CD

8:30 a.m. - 5:00 p.m.

Ovarian Biology Satellite Meeting

AQUA 310 AB

8:30 a.m. - 5:00 p.m.

Placenta Satellite Meeting

AQUA EF

     

12:00 p.m. - 1:00 p.m.

Diversity and Inclusion Forum
Alden Landry, MD, MPH
Beth Israel Deaconess Medical Center
Office of Diversity Inclusion and Community Partnership, Harvard
Medical School
*Lunch is included for those that register

COBALT 500

6:30 p.m. - 8:00 p.m.

Welcome Reception
Join us for socializing, wine and light appetizers.

SAPPHIRE WEST FOYER/SAPPHIRE TERRACE 

Thursday, March 8

7:00 a.m. - 6:00 p.m.

Registration

SAPPHIRE WEST FOYER

8:00 a.m. - 9:00 a.m.

Welcome

Sandra Davidge, PhD, SRI President 
Marilyn Cipolla, PhD, 2018 Program Director

SAPPHIRE A - J

8:10 a.m. - 9:00 a.m.

President's Distinguished Lecture I
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits

SAPPHIRE A - J

How Cells Export Proteins
Randy W. Schekman, PhD
Professor of Molecular and Cell Biology
University of California in Berkeley

9:00 a.m. - 10:00 a.m.

New Investigator Plenary
Funded by the Past President's Fund

Moderators:
Sandra Davidge, PhD, 2017 - 2018 SRI President
James Roberts, MD, 1996 - 1997 SRI Past President 

SAPPHIRE A - J

9:00 a.m. - 9:15 a.m.

3D Architecture of Endometrial Glands in Relation to Stem Cell Organisation.
Nicola Tempest, MBChB

9:15 a.m. - 9:30 a.m.

Bone Marrow-Derived Progenitors Become Decidual Cells and Are Essential for Implantation and Pregnancy Maintenance
Reshef Tal, MD, PhD

9:30 a.m. - 9:45 a.m.

Antenatal Glucocorticoid Treatment Disrupts the Maternal and Fetal Methionine Cycle
Alexandros Mouratidis

9:45 a.m. - 10:00 a.m.

Maternal Obesity is Associated with Altered Cardiac Structure and Function in Neonates: UPBEAT TEMPO Heart Study
Ellie Battersby, BSc

10:00 a.m. - 12:00 p.m.

Poster Session I
*Coffee and biscuits will be served

SAPPHIRE C - P

12:00 p.m. - 1:30 p.m.

Special Lunchtime Panel:
How to Effectively Network and Collaborate Locally and Globally

Moderators:
Marilyn Cipolla, PhD
Stephen Matthews, PhD

SAPPHIRE A - J

Panel Participants:
Randy Schekman, PhD, Ursula Kaiser, MD, Marc E. A. Spaanderman, MD, PhD, Lucilla Poston, PhD, Diana Bianchi, MD, Sarah Anne Robertson, PhD

 

1:30 p.m. - 3:30 p.m.

Concurrent Oral Presentations I

Various

Clinical and Translational Perinatology I
Moderators:
Ira M. Bernstein, MD
Chrisite Walker

SAPPHIRE 400 AB

1:30 p.m. – 1:45 p.m.

Conditional Xbp1 Deletion Ameliorates Maternal Diabetes-Induced ER Stress and Neural Tube Defects through Restoration of miR-17 Expression
Penghua Yang, Peixin Yang

1:45 p.m. – 2:00 p.m.

Immediate Perioperative Predictors of Survival inTTTS
Jessica Ehrig, Nicholas Behrendt, Megan Lagueux, Kenneth W. Liechty, Michael V. Zaretsky, Timothy M. Crombleholme, Henry L. Galan

2:00 p.m. – 2:15 p.m.

Effects of Medication Intake in Early Pregnancy on the Fetal Fraction ofCell-Free DNA
Maggie J Kuhlmann-Capek, Prapti Singh, Luis Monsivais, Violetta Lozovyy, Lauren Gallagher, Nathan Kirsch, Elizabeth Florence, Victoria Petruzzi, Jeffrey Chang, Sofia Buitrago, Paul Walden, Benjamin Gardner, Mary Munn, Giuseppe Chiossi, Maged Costantine

2:15 p.m. – 2:30 p.m.

Oral Steroids for Maturation of the Preterm Lung: Pharmacokinetic and Efficacy Data from a Sheep Model of Pregnancy
Matt Kemp, Augusto Schmidt, Haruo Usuda, Masatoshi Saito, Peter Eddershaw, Alan Jobe

2:30 p.m. – 2:45 p.m.

Identification of a Novel 17OHPC Metabolite in Maternal and Cord Blood
Molly J. Stout, Hideji Fujiwara, Kathiresan Krishnan, Douglas F. Covey, Daniel Ory, George A. Macones, Methodius G. Tuuli

2:45 p.m. – 3:00 p.m.

Isolating Direct Adverse Effects of Betamethasone and Dexamethasone on the Fetal Heart: Studies in the Chick Embryo
Tessa A. Garrud, Noor E. Teulings, Fiona G. Conlon, Sage G. Ford, Youguo Niu, Lisa M Nicholas, Jan B Derks, Sue E Ozanne, Dino A. Giussani

3:00 p.m. – 3:15 p.m.

IL-1 Receptor Antagonist Improves Trophoblast Invasion, Endothelial Development and ZIKV Sequelae in Offspring
Jun Lei, Meghan Vermillion, Bei Jia, Michael McLane, Mia Feller, Amanda Brown, Sabra Klein, Irina Burd

3:15 p.m. – 3:30 p.m.

Cytokine Response to Zika Virus (ZIKV) Infection in Non-Pregnant and Pregnant Olive Baboons
Sunam Gurung, Darlene N Reuter, Ashley Martin, Jamie Dubaut, Alisha Preno, James Papin, Dean Myers

Gynecology I
Moderators:
Serdar Bulun, MD
Shani Chibber, MSEB

AQUA D

1:30 p.m. – 1:45 p.m.

Establishment of a Mouse Model of Deep Infiltrating Endometriosis
Xishi Liu, Dingmin Yan, Sun-Wei Guo

1:45 p.m. – 2:00 p.m.

Activation of AKT by Wnt4 as a Novel Regulator of Uterine Leiomyoma Stem Cell Function
Shimeng Liu, Ping Yin, Stacy A. Kujawa, Serdar E. Bulun

2:00 p.m. – 2:15 p.m.

Large-Scale Data Analysis on Endometriosis from the UK Biobank Reveals Novel Genetic Loci
Nilufer Rahmioglu, James Cook, International Endometriosis Genomic Consortium (IEGC), Christian Becker, Andrew Morris, Krina Zondervan

2:15 p.m. – 2:30 p.m.

Ulipristal Acetate Reverses Impaired Autophagy in Human Uterine Fibroids
Ihor Atabiekov, Ayman Al-Hendy, Nahed Ismail, Abdeljabar El Andaloussi

2:30 p.m. – 2:45 p.m.

Bone Marrow-Endometrial Stromal Cell Fusion in Experimental Endometriosis
Aya Tal, Reshef Tal, Shafiq Shaikh, Ramanaiah Mamillapalli, Hugh S. Taylor

2:45 p.m. – 3:00 p.m.

Role of miR-451 in Regulating Endometrial Cell Proliferation Associated with Endometriosis
Niraj Joshi, Samantha Bond, Asgerally Fazleabas

3:00 p.m. – 3:15 p.m.

Understanding the Genetic Basis of Transgender Identity
John G. Theisen, Mary S. Filchak, Viji Sundaram, Lynn P. Chorich, Megan E. Sullivan, Michael J. Friez, Hyung-Goo Kim, Lawrence C. Layman

3:15 p.m. – 3:30 p.m.

Next-Generation Sequencing Reveals Differentially Expressed Small Non-Coding RNAs (sncRNAs) in Leiomyomas
Tsai Der Chuang, Yeming Xie, Wei Yan, Omid Khorram

Parturition I
Moderators:
Abbie C. Johnson, PhD
David A. MacIntyre, PhD

AQUA C

1:30 p.m. – 1:45 p.m.

Electrical Impedance Spectroscopy Predicts Preterm Delivery in Asymptomatic Women
Victoria Stern, Timothy J Healey, Zi-Qiang Lang, Brian H. Brown, Dilly O. Anumba

1:45 p.m. – 2:00 p.m.

Pro-Inflammatory Cytokines and AP-1 Transcription Factors Mediate 20 alpha HSD Induction in Myometrium during Labour
Lubna Nadeem, Oksana Shynlova, Sam Mesiano, Stephen Lye

2:00 p.m. – 2:15 p.m.

Cell-Free DNA Release by Mouse Fetal Membranes
Mark Phillippe, Sharareh Adeli

2:15 p.m. – 2:30 p.m.

Type I Interferons Instigate Fetal Demise after Zika Virus Infection
Laura J. Yockey, Kellie A Jurado, Nitin Arora, Alon Millet, Tasfia Rakib, Kristin M Milano, Andrew K Hastings, Erol Fikrig, Yong Kong, Scott Weatherbee, Harvey J Kliman, Carolyn B. Coyne, Akiko Iwasaki

2:30 p.m. – 2:45 p.m.

Rapid Mucosal Metabolome Profiling by Desorption Electrospray Ionization MS (DESI-MS) for Prediction of Preterm Pre-Labour Rupture of Membranes (PPROM)
Holly V. Lewis, Pamela Pruski, Richard G. Brown, Lindsay Kindinger, Yun Lee, Phillip Bennett, Zoltan Takats, David MacIntyre

2:45 p.m. – 3:00 p.m.

Immune Cells in Crosstalk with the Placental Microbiome - How Fusobacterium Nucleatum Affects Macrophage Function and Its Trophoblast Interaction
Rebekka Einenkel, Damián O. Muzzio, Jens Ehrhardt, Martha Heusler, Marek T. Zygmunt

3:00 p.m. – 3:15 p.m.

CD161 Promotes Prenatal Immune Suppression of Pro-Inflammatory PLZF+ T Cells
Joanna Halkias, Elze Rackaityte, Ventura Mendoza, Trevor Burt

3:15 p.m. – 3:30 p.m.

Cervical Gene Delivery of Human Beta-Defensin-3 (HBD-3) Reduces E.coli K1 Ascending Infection and Increases the Proportion of Live Births in Pregnant Mice
Natalie Suff, Rajvinder Karda, Jo Ng, Dany Perocheau, Mona Bajaj-Elliott, Suzanne MK Buckley, Simon N Waddington, Donald Peebles

Placenta I
Moderators:
Laura Brouwers, MD
Nicholas P. Illsley, D.Phil

AQUA AB

1:30 p.m. – 1:45 p.m.

Altered Placental Expression of Candidate Blood Markers of Severe Fetal Growth Restriction is Driven by Hypoxia
Natasha De Alwis, Sally Beard, Natalie Binder, Tu’uhevaha Kaitu’u-Lino, Susan Walker, Stephen Tong, Natalie J. Hannan

1:45 p.m. – 2:00 p.m.

Lysophosphatidylcholine; a Critical Form of Fatty Acids in Fetal Circulation
Veronique Ferchaud-Roucher, Elena Silva, Thomas Jansson, Theresa L. Powell

2:00 p.m. – 2:15 p.m.

Omega-3 Polyunsaturated Fatty Acids Inhibit Trophoblast Inflammasome Activation and Preterm Birth
Chie-Pein Chen, Chia-Yu Chen, Chang-Ching Liu, Cheng-Yi Chen

2:15 p.m. – 2:30 p.m.

Longitudinal Study of Loss of Imprinting in First Trimester CVS Samples Compared to Term
Jonathan Riel, Maya Kappil, Jia Chen, Luca Lambertini, QIan Li, Yula Ma, Ronald Wapner, William Grobman, Men-Jean Lee

2:30 p.m. – 2:45 p.m.

Syndecan-4 Regulates Extravillous Cytotrophoblast Cell Migration by Coordinating Protein Kinase C-Alpha Activation
Mariyan Jeyarajah, Brianna Kops, Gargi Jaju, Stephen Renaud

2:45 p.m. – 3:00 p.m.

Maternal Angiotensinogen and Fetal Sex Affect Placental Bed Angiogenesis in Mouse Model of Fetal Growth Restriction
Jessica F Hebert, Allison Felker, Terry K. Morgan

3:00 p.m. – 3:15 p.m.

Changes in the Epigenetic Landscape Reveal Genes Crucial for Human Trophoblast Differentiation
Youn-Tae Kwak, Sribalasubashini Muralimanoharan, Carole R. Mendelson

3:15 p.m. – 3:30 p.m.

Evaluation of Diffusion MRI Metrics to Assess Placental Structure and Function
Anna McCormick, Thomas Steigerwald, Robert Wujek, Melissa Prah, Kevin Boyd, Nghia Vo, Judith Hibbard, Kathleen Schmainda

Preeclampsia I
Moderators:
Yoel Sadovsky, MD
Floor Spaans, PhD

AQUA EF

1:30 p.m. – 1:45 p.m.

Targeted Nanoparticles for Delivery of sFlt-1e15a-Specific siRNA to the Placental Syncytiotrophoblast; a Novel Therapy for Pre- Eclampsia?
Chloe Logue, Susan Greenwood, Stephen Tong, Natalie Hannan, Lynda K. Harris

1:45 p.m. – 2:00 p.m.

Lysosome Biogenesis and Exocytosis is Augmented in Preeclampsia
Leonardo Ermini, Jonathan Ausman, Martin Post, Isabella Caniggia

2:00 p.m. – 2:15 p.m.

Circulating mRNA Coding Adrenomedullin is Decreased in Women Destined to Develop Pre-Eclampsia and May Be of Placental and/or Endothelial Origin
Carole-Anne Whigham, Teresa MacDonald, Sue Walker, Natalie Hannan, Ping Canon, Tuong Vi Nguyen, Stephen Tong, Tu’uhevaha Kaitu’u- Lino

2:15 p.m. – 2:30 p.m.

Regulatory T Cells Regulate Uterine Artery Function to Impact Fetal Growth
Alison S Care, Stephane L Bourque, Jude S Morton, Emma P Hjartarson, Sarah A Robertson, Sandra T Davidge

2:30 p.m. – 2:45 p.m.

Can Maternal Vascular Lesions in the Placenta Predict Severity and Recurrence of Hypertensive Disorders of Pregnancy?
Alisse Hauspurg, Vanessa Assibey-Mensah, W Tony Parks, Arun Jeyabalan, James M Roberts, Janet Catov

2:45 p.m. – 3:00 p.m.

Flow Mediated Dilation; the Effect of Aging in Women with a History of Vascular Complicated and Uncomplicated Pregnancy
Veronica A Lopes van Balen, Chahinda Ghossein-Doha, Julia J Spaan, Sander MJ van Kuijk, Arnold P Hoeks, Koen D Reesink, Marc EA Spaanderman

3:00 p.m. – 3:15 p.m.

Reduced Retinoic Acid in Preeclamptic Decidua
Augustine Rajakumar, Martina Badell, Maureen Kane, Hongyan Qu, Robert N Taylor, Neil Sidell

3:15 p.m. – 3:30 p.m.

Placental Uric Acid Transport System and Its Impact on Fetal Development
Benjamin P. Lüscher, Philipp Schneider, Daniel Surbek, Marc U. Baumann

Reproductive Biology I
Moderators:
Sonia Herraiz, PhD
Paolo Francesco Rinaudo, MD

SAPPHIRE 410 AB

1:30 p.m. – 1:45 p.m.

Molecular Control of Steroid Hormone Production via Post-Transcriptional Regulation of the Steroidogenic Acute Regulatory Protein by the lncRNA H19
Yong Chen, Chunrong Qin, Xia Xi, Amanda N. Kallen

1:45 p.m. – 2:00 p.m.

Human Embryo-Derived Extracellular Vesicles Contain RNAs Involved in Embryogenesis and Can Modify the Endometrial Cell Transcriptomic Profile Upon Incorporation
Elisa Giacomini, Riccardo Vago, Sofia Makieva, Dejan Lazarevic, Sabrina Minetto, Enrico Papaleo, Paola Viganò

2:00 p.m. – 2:15 p.m.

Correlating Transcriptome and DNA Methylome Changes in Human Oocyte Maturation
Bo Yu, Naresh Jayavelu, Shannon Ferrell, Genevieve Neal-Perry, Timothy Schimmel, Jacque Cohen, R. David Hawkins

2:15 p.m. – 2:30 p.m.

Epigenetic Clock Model of Somatic Aging Accurately Predicts Chronologic Age When Applied to White Blood Cells But Not Cumulus Cells in Reproductive Age Women
Scott J Morin, Xin Tao, Jenna Bedard, Jessica Landis, Yiping Zhan, Richard Scott, Emre Seli

2:30 p.m. – 2:45 p.m.

Loss of the Grb2 Associated Binding Protein 3 is Associated with Poor Uterine NK Cell Proliferation and Placental Accreta in Mice
Anna Sliz, Kristin Lampe, Alzbeta Godarova, Helen Jones, Kasper Hoebe

2:45 p.m. – 3:00 p.m.

LPS-Exposed Fetal Membranes Activate Neutrophils and Increase Neutrophil Extracellular Trap Formation
Mancy Tong, Julie A. Potter, Gil Mor, Vikki M. Abrahams

3:00 p.m. – 3:15 p.m.

Peri-Implantation Progesterone Determines Regulatory T Cell Competence to Impact Late Gestation Pregnancy Outcome in Mice
Sarah A Robertson, Ella S. Green, Shaun R. McColl, Lachlan M. Moldenhauer

3:15 p.m. – 3:30 p.m.

Role of WNT/CTNNB1 Pathway in Differentiation of Human Induced Pluripotent Stem Cells to Endometrial Stroma-Like Cells
Kaoru Miyazaki, Matthew T Dyson, John S Coon, Tetsuo Maruyama, Serdar E. Bulun

3:30 p.m. - 4:00 p.m.

Coffee Break

SAPPHIRE WEST FOYER

4:00 p.m. - 6:00 p.m.

Mini Symposia I

Various

Viral Infections in Pregnancy: When the Fetus is Caught in the Cross-Fire
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
Kristina Adams Waldorf, MD
Michelle Silasi, MD

AQUA AB

4:00 p.m. – 4:30 p.m.

The Placenta as the Front Line and Battleground for Viral Infections: Lessons from Studying the Zika Virus
Indira Mysorekar, PhD 

4:30 p.m. – 5:00 p.m.

The Fetus Under Siege:  Maternal Cytomegalovirus Infections During Pregnancy
Karen Racicot, PhD

5:00 p.m. – 5:30 p.m.

Viral Injury of the Fetal Brain: Ceasefire at the Expense of Normal Development?
Irina Burd, MD, PhD

5:30 p.m. – 6:00 p.m.

Our War on the Zika Virus: Big Teams, Animal Models, and How We End the Epidemic
Peta Grigsby, PhD

Endometrial Antecedents of Adverse Pregnancy Outcomes
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
Kirk P. Conrad, MD
Emiel D. Post Uiterweer, MD, PhD

AQUA C

4:00 p.m. – 4:30 p.m.

Emerging Role for Dysregulated Decidualization in the Genesis of Preeclampsia
Kirk P. Conrad, MD 

4:30 p.m. – 5:00 p.m.

Epigenetics of the Decidua in Parturition
Adrian Erlebacher, MD, PhD

5:00 p.m. – 5:30 p.m.

Impact of Natural Killer Cell KIR Haplotype on Recurrent Miscarriages and Implantation Failure
Juan Garcia-Velasco, MD

5:30 p.m. – 6:00 p.m.

Uterine Immune Cell Contribution to Pre-­eclamptic Pathology
Guy Whitley, PhD

Autophagy and Reproduction
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
John Challis, PhD
Alina Maloyan, PhD

AQUA D

4:00 p.m. – 4:30 p.m.

Uterus and Autophagy
Felice Petraglia, MD

4:30 p.m. – 5:00 p.m.

Trophoblast and Autophagy
Isabella Caniggia, MD, PhD

5:00 p.m. – 5:30 p.m.

Obesity, Autophagy and the Placenta
Alina Maloyan, PhD

5:30 p.m. – 6:00 p.m.

Autophagy and Parturition
Steven S. Witkin, PhD

DNA Repair and Micro-RNA in Reproductive Aging and Gynecologic Diseases
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
Shannon Hawkins, MD, PhD
Kutluk Oktay, MD, PhD

AQUA EF

4:00 p.m. – 4:30 p.m.

Role of BRCA Function and DNA Repair in Reproductive Aging
Kutluk Oktay, MD, PhD

4:30 p.m. – 5:00 p.m.

Targeting miRNA Pathways in Gynecologic Diseases
Shannon Hawkins, MD, PhD

5:00 p.m. – 5:30 p.m.

Role of MicroRNA and Long Noncoding RNA in Steroidogenesis
Amanda N. Kallen, MD

5:30 p.m. – 6:00 p.m.

Ageing, Menopause and DNA Repair
Joop S.E. Laven, MD, PhD

SRI-SSR Joint Session: Assisted Reproductive Technologies and Future Health
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
Paolo Rinaudo, MD, PhD
Monica Mainigi, MD

SAPPHIRE 410 AB

4:00 p.m. – 4:30 p.m.

Epidemiology of Children Conceived by ART
Barbara Luke, ScD, MPH

4:30 p.m. – 5:00 p.m.

Trophoblast Lineage Specification: Implications for Assisted Reproduction
Francesca Soncin, PhD

5:00 p.m. – 5:30 p.m.

Genomic Imprint Regulation in Gametes and Early Embryos
Melissa RW Mann, PhD

5:30 p.m. – 6:00 p.m.

The Effect of Culture on the Embryo Phenotype in the Bovine Model
Marc Andre Sirard, DVM, PhD

Environmental Exposures and Reproductive Outcomes
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
Thomas McElrath, MD, PhD
Laura Goetzel, MD, MPH

SAPPHIRE 400 AB

4:00 p.m. – 4:30 p.m.

Endocrine Disruptors and Pregnancy/Birth Outcome
Vasantha Padmanabhan, PhD

4:30 p.m. – 5:00 p.m.

Environmental Exposures and Ovulatory Disorders
Shurthi Mahalingaiah, MD

5:00 p.m. – 5:30 p.m.

Associations Between High Phthalate and Bis-Phenol Exposures and the Risk of Preeclampsia and Pregnancy Associated Hypertension
David Cantonwine, PhD

5:30 p.m. – 6:00 p.m.

Environmental Chemical Exposures and Gestational Diabetes Risk: Epidemiological Evidence from High and Average Risk Populations
Tamarra James-Todd, PhD

6:15 p.m. - 7:45 p.m.

Connection Corners
New, Early Career Researcher and Mid-Career Investigators are invited to come meet and 'connect' with Senior Investigators about jobs, career advice or just some friendly banter. Drinks and light appetizers provided.

Sapphire West Terrace

Friday, March 9

7:00 a.m. - 6:00 p.m.

Registration

SAPPHIRE WEST FOYER

8:00 a.m. - 9:00 a.m.

President's Distinguished Lecture II
Eligible for 1.0 AMA PRA Category 1 Credits ™ / 1.0 Category I College Cognate Credits

SAPPHIRE A - J

Genetic and Molecular Pathways Controlling Puberty:
The Importance of Collaboration in Translational Research

Ursula B. Kaiser, MD
Chief, Division of Endocrinology, Diabetes and Hypertension
Harvard Medical School

9:00 a.m. - 11:00 a.m.

Poster Session II
*Coffee and biscuits will be served

SAPPHIRE C - P

11:00 a.m. - 12:30 p.m.

Concurrent Oral Presentations II

Various

 

Clinical and Translational Perinatology I
Moderators:
Peter W. Nathanielsz, MD, PhD, ScD Barbara S. Verstraeten, MD

SAPPHIRE 410 AB

11:00 a.m. – 11:15 a.m.

Transcriptional Mechanisms of Sex-Specific Postnatal Cardiac Dysfunction Programmed by Maternal Obesity in Mice
Owen R. Vaughan, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

11:15 a.m. – 11:30 a.m.

Thyroid Hormone Stimulates Cardiomyocyte Metabolic Maturation in the Late Term Sheep Heart
Natasha Chattergoon, Samantha Louey, Sonnet Jonker, George Giraud, Kent Thornburg

11:30 a.m. – 11:45 a.m.

Cardiovascular Susceptibility of Adult Male and Female Offspring Born to Advanced Maternal Aged Rat Dams
Amin Shah, Christy L. Cooke, Jude S Morton, Anita Quon, Sandra T. Davidge

11:45 a.m. – 12:00 p.m.

F2 Fetal Nephron Number Benefits of Endurance Exercise Training for Females Born Small on a High Fat Diet
Mary E. Wlodek, Jessica Briffa, Sogand S. Hosseini, Viktoria Richter, Dayana Mahizir, Kristina Anevska, Glenn D. Wadley, Deanne H. Hryciw, Karen M. Moritz

12:00 p.m. – 12:15 p.m.

Non-Invasive Biomarkers of Cardiovascular Dysfunction in Adult Offspring Programmed by Developmental Hypoxia
Rama Lakshman, Ana-Mishel Spiroski, Michael P. Murphy, Dino A. Giussani

12:15 p.m. – 12:30 p.m.

Developmental Programming of Circulating Cortisol and Its Receptor in the Aorta of Late Gestation Fetuses of Obese, Undernourished, Control Mothers
Cun Li, Hillary F. Huber, Dongbin Xie, Peter W. Nathanielsz

Fetus I
Moderators:
Maureen Keller-Wood, PhD
Miguel A. Zarate, PhD, DVM

AQUA C

11:00 a.m. – 11:15 a.m.

Inhibition of mTOR, Activation of Amino Acid Response (AAR) and IGFBP-1 Hyperphosphorylation, in the Fetal Liver Precede the Development of IUGR in Baboons Following Maternal Nutrient Restriction
A. Sutherland, C. Li, P. Nathanielsz, T. Jansson, M. Gupta

11:15 a.m. – 11:30 a.m.

What’s That Smell? First Evidence of Cardio- Protective Actions of Hydrogen Sulphide in the Developing Heart
Rita M. Hess, Youguo Niu, Tess A Garrud, Kimberley J. Botting, Sage G. Ford, Dino A. Giussani

11:30 a.m. – 11:45 a.m.

Loss of Uncoupling Protein 2 Explains Hyper-Insulin Secretion Following Persistent Adrenergic Receptor Signaling in Fetal Sheep Islets
Amy Kelly, Melissa Davis, Leticia Camacho, Hailey Davenport, Nathan Steffens, Sean Limesand

11:45 a.m. – 12:00 p.m.

Chronic Leucine Supplementation Potentiates Glucose Stimulated Insulin Secretion in Fetal Sheep
Brit H. Boehmer, Laura D. Brown, Stephanie R. Wesolowski, William W. Hay, Jr., Paul J. Rozance

12:00 p.m. – 12:15 p.m.

Day 5 vs. Day 6 Blastocysts: Early Time Lapse Markers Differ But There Are Similar Rates of Euploid Embryos
Dana Kimelman, Ijeoma Okeigwe, Rafael Confino, Jaclyn Lambe-Steinmiller, Edmond Confino, Lee Shulman, Jared Robins, John Zhang, Mary Ellen Pavone

12:15 p.m. – 12:30 p.m.

Excess Maternal Cortisol Alters Placental and Fetal Cardiac Metabolism at Term
Jacquelyn Walejko, Serene Joseph, Arthur Edison, Maureen Keller-Wood

Gynecology II
Moderators:
Asgi T. Fazleabas, PhD>
Ijeoma Okeigwe, MD, MPH
AQUA EF

11:00 a.m. – 11:15 a.m.

PD-L1 Expression is Regulated by Med12 and INF-γ in Human Uterine Fibroids
Abdeljabar El Andaloussi, Prosper Igboeli, Sunil Halder, Ayman Al-Hendy, Nahed Ismail

11:15 a.m. – 11:30 a.m.

H19 LncRNA Regulates Fibroids-Associated Gene Expression via Both Posttranscriptional and Epigenetic Mechanisms
Tiefeng Cao, Na Zhang, Martin Mueller, Pinar Kodaman, Hugh Taylor, Yingqun Huang

11:30 a.m. – 11:45 a.m.

GATA2 in Normal Endometrium and GATA6 in Endometriosis Are Associated with Genome- Wide H3K27ac Histone Modification and Active Transcription of Genes Essential for Tissue Phenotypes
Christia Angela Sison, Shimeng Liu, Serdar E Bulun, Matthew T Dyson

11:45 a.m. – 12:00 p.m.

Caloric Restriction Dramatically Stalls Lesion Growth in Mice with Induced Endometriosis
Sun-Wei Guo, Bo Yin, Xishi Liu

12:00 p.m. – 12:30 p.m.

miR-451a-c-MYC Pathway Regulation of 60S Acidic Ribosomal Protein P1 (RPLP1) Expression: A Novel Pathway in Endometriotic Lesion Tissue Survival
Zahraa Alali, Tommaso Falcone, Warren B Nothnick

12:15 p.m. – 12:30 p.m.

Prostaglandin E2 Signaling and Epigenetic Regulation of Proapoptotic miRNA15a in Endometriosis
Joe A Arosh, Jone A Stanley, Kaylon Bruner-Tran, Kevin K Osteen, Sakhila K Banu

Maternal Biology And Health
Moderators:
K. Joseph Hurt, MD, PhD
Ronald R. Magness, PhD

AQUA AB

11:00 a.m. – 11:15 a.m.

Low Intensity Physical Activity May Protect against Spontaneous Preterm Labor through IL10 Pathways
Valerie Steckle, Oksana Shynlova, Ryan Seeto, Sheryl Hewko, Alan Bocking, Stephen Lye

11:15 a.m. – 11:30 a.m.

Piezo1 Cation Channels: A Role in the Regulation of Uteroplacental Blood Flow?
Nga Ling Ko, Natalia Gokina, Liam John, George Osol

11:30 a.m. – 11:45 a.m.

Cardiovascular Risk Assessment and Follow-Up of Women after Hypertensive Disorders of Pregnancy
Rachel A. Gladstone, Jessica Pudwell, Graeme N. Smith

11:45 a.m. – 12:00 p.m.

Multiomics Analysis of the Immunome, Transcriptome, Microbiome, Proteome, Metabolome in Term Pregnancy
Sajjad Ghaemi, Martin Angst, Brice Gaudilliere, Nima Aghaeepour, On behalf of the March of Dimes Prematurity Center at Stanford University (47 co-authors)

12:00 p.m. – 12:15 p.m.

Pregnancy-Augmented Uterine Artery CBS/H2S Biosynthesis is Downregulated in the Rat Model of Preeclampsia Induced by Reduced Uterine Perfusion Pressure (RUPP)
Thomas J. Lechuga, Jing Zhou, Guofeng Yang, Nicole A. Nguyen, Sassi Sarnthiyakul, Fengying Xing, Yao Li, Xuejin Chen, Dongbao Chen

12:15 p.m. – 12:30 p.m.

Impaired Function of Cerebral Parenchymal Arterioles in Experimental Preeclampsia
Abbie Johnson, Marilyn Cipolla

Parturition II
Moderators:
Stephen J. Lye, PhD
Lynne Sykes, BSc, MBBS, PhD

AQUA D

11:00 a.m. – 11:15 a.m.

Potential Role of Vitamin D Metabolism in the Timing of Birth
Alina P. Montalbano, Ailing Yang, Carole R. Mendelson

11:15 a.m. – 11:30 a.m.

FKBP5 Gene Depletion Prevents Maternal Stress-Induced Preterm Birth (PTB) and Fetal Growth Restriction (FGR)
Ozlem Guzeloglu-Kayisli, Kellie Larsen, Sefa Arlier, Nihan Semerci, Frederick Schatz, Umit Kayisli, Charles Lockwood

11:30 a.m. – 11:45 a.m.

Labor-Associated Genes Are Marked by Bivalent Histone Modifications in the Amnion
Carolyn M. Mitchell, Jonathan J. Hirst, Murray D. Mitchell, Henry G. Murray, Tamas Zakar

11:45 a.m. – 12:00 p.m.

Gestational Profiling of Mouse Plasma Exosomes Reveals Inflammatory Biomarkers Increase Prior to Parturition
Samantha Sheller-Miller, Ramkumar Menon

12:00 p.m. – 12:15 p.m.

The Unfolded Protein Response Regulates Inflammatory IL6 Production in the Pregnant Uterine Myocyte in the Absence of a Microbial Infection
Chandrashekara Kyathanahalli, Sonia Hassan, Pancharatnam Jeyasuria, Jennifer Condon

12:15 p.m. – 12:30 p.m.

Inflammation-Induced Preterm Birth Initiates Placental Immune Response Distinct from Placental Immunobiology at Term
Emma L. Lewis, Guillermo Barila, Amy G. Brown, Paige M. Porrett, Michal A. Elovitz

Reproductive Endocrinology and Infertility I
Moderators:
Nataki C. Douglas, MD, PhD
Patricia T. Jimenez, MD

SAPPHIRE 400 AB

11:00 a.m. – 11:15 a.m.

Phytoestrogens (Soy-Derived Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells
Silvia Perez, Stefania Salsano, Alicia Quiñonero, Francisco Dominguez

11:15 a.m. – 11:30 a.m.

Peripheral Blood NK Cytotoxicity Levels as a Biomarker in Non-Pregnant and Pregnant Women with Reproductive Failure
Maria D. Salazar Garcia, Rachel Reed, Youssef Hussein, Haidy Elazzamy, Annie Skariah, Svetlana Dambaeva, Alice Gilman-Sachs, Kenneth Beaman, Joanne Kwak-Kim

11:30 a.m. – 11:45 a.m.

FSH Signaling is Augmented by AKAP13
Ashlie Sewdass, Paul H. Driggers, Kamaria C. Vaught, James H. Segars

11:45 a.m. – 12:00 p.m.

Mitochondrial Function in PCOS Oocyte is Affected More by Prenatal Androgen Than by Adult Androgen Exposure
Neil R. Chappell, Beth Zhou, William E. Gibbons, Amy Schutt, Chellakkan S. Blesson

12:00 p.m. – 12:15 p.m.

Steroidogenic Factor 1 (SF-1) is Essential for Sertoli Cell Survival in the Developing Fetal Testis
Prashanth Anamthathmakula, Chandra S. Miryala, Jennifer C. Condon, Pancharatnam Jeyasuria

12:15 p.m. – 12:30 p.m.

Stem Cell Therapy of Polycystic Ovary Syndrome (PCOS): Implantation of Human Bone Marrow Stem Cells Enhance Energy Expenditure and Improves Hyperandrogenemia in an Immune- Competent Severe PCOS Mouse Model
Abdeljabar El Andaloussi, Prosper Igboeli, Mona Omar, Ayman Al-Hendy

12:30 p.m. - 2:00 p.m.

Lunch and Learn Symposium I:
Building Cohorts: Dream Big, Start Small. Practical Considerations in Reproductive Cohort Construction, Recruitment, Maintenance, Data Management, and their Utility

Moderators:
Shruthi Mahalingaiah, MD
James M Roberts, MD

SAPPHIRE 410 AB

Creation of a Robust Cohort for Generalized Research into the Hypertensive Disorders of Pregnancy: Experience from Iowa
Mark Santillan, MD, PhD
University of Iowa Hospitals and Clinics

How to Create and Maintain a Longitudinal Pregnancy Cohort Recruited in the Clinical Environment: Experience from the LIFECODES Birth Cohort in Boston
Thomas McElrath, MD, PhD
Brigham & Women's Hospital

Special Considerations and Challenges in the Development of Birth Cohorts in the Developing World: Experience from Brazil
Arundhathi Jeyabalan, MD
University of Pittsburgh

Capturing the Maternal Exposome & Metabolome & Birth Outcomes in an Obstetrically Sourced Population. Experience from the MMIP Cohort
Vasantha Padmanabhan, PhD
University of Michigan

12:30 p.m. - 2:00 p.m.

Lunch and Learn Symposium II: 
Updates from NICHD: Strategic Planning, Funding and Global Initiatives

Speaker:
Diana Bianchi, MD

SAPPHIRE A- J

12:30 p.m. - 2:00 p.m.

Pfizer - SRI President's Presenter's Awards Lunch

*The SRI President's Presenter's Awards Lunch is a Non-CME event.

AQUA 300 AB

2:00 p.m. - 4:00 p.m.

Mini Symposia II

Various

Emerging Reproductive Technologies and Therapeutic Editing
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
Emre Seli, MD
Reshef Tal, MD, PhD

AQUA AB

2:00 p.m. – 2:30 p.m.

Mitochondria and Assisted Reproduction: Diagnostic and Therapeutic Implications
Emre Seli, MD

2:30 p.m. – 3:00 p.m.

Therapeutic Editing of the Genome of the Embryo
Jon D. Hennebold, PhD

3:00 p.m. – 3:30 p.m.

Ovarian Rejuvenation: Emerging Technologies
Sonia Herraiz, PhD

3:30 p.m. – 4:00 p.m.

Novel Approaches to Study Cell-lineage Decisions in Preimplantation Embryos
Sophie Petropoulos, PhD

SRI-ISSHP Joint Session: Preeclampsia: A Life-Long Disorder
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
Ananth Karumanchi, MD
Floor Spaans, PhD

AQUA C

2:00 p.m. – 2:30 p.m.

Mechanisms of Cardic Remodeling in Preeclampsia
Basky Thilaganathan, MBBS

2:30 p.m. – 3:00 p.m.

Anti-hypertensive Therapy – What’s Next?
Peter Von Dadelszen, MD

3:00 p.m. – 3:30 p.m.

Preeclampsia in Low Resource Settings: How to Make a Difference
Tom Easterling, MD

3:30 p.m. – 4:00 p.m.

Preeclampsia: A Life-Long Disorder
Mark Brown, MD

Setting the Research Agenda for Transgender Medicine in 2018
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
John Randolph, Jr., MD
Molly Moravek, MD

AQUA C

2:00 p.m. – 2:30 p.m.

Biologic Origins of Gender Identity
Stephen Rosenthal, MD

2:30 p.m. – 3:00 p.m.

Bowel and Bladder Consequences of Cross-Sex Hormone Therapy
Mitch B. Berger, MD

3:00 p.m. – 3:30 p.m.

Models for Studying Fertility in Transgender Adults
Molly Moravek, MD

3:30 p.m. – 4:00 p.m.

Addition of Estradiol to Testosterone Therapy and Implications for Treating Transgender Youth in Mice
Laura Goetz, MD/PhD Candidate

The Impact of Obesity on Reproduction and Transgenerational Health: Chicken or the Egg or the Sperm?
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
Alex J Polotsky, MD, MS
Jaime Lo, MD

AQUA EF

2:00 p.m. – 2:25 p.m.

Reproductive Hormones and Obesity
Alex J Polotsky, MD, MS

2:25 p.m. – 2:50 p.m.

The Impact of Obesity on Oocyte
Emily Jungheim, MD, MS

2:50 p.m. – 3:15 p.m.

Obesity, Male Infertility, and the Sperm Epigenome
James Hotaling, MD

3:15 p.m. – 3:40 p.m.

The Impact of Obesity on Placenta and Intrauterine Growth
Bernardo J. Krause, Sr., PhD

3:40 p.m. - 4:00 p.m.

Speaker Panel with Q&A 

New Frontiers in Perinatal Neuroprotection and Regeneration
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
Daniel Surbek, MD
Anna Euser, MD, PhD

SAPPHIRE 410 AB

2:00 p.m. – 2:30 p.m.

Distinguishing Arterial Ischemic Stroke from Neonatal Hypoxic-Ischemic Encephalopathy
Ernest Graham, MD

2:30 p.m. – 3:00 p.m.

Stem Cell Therapy for Hypoxic-Ischemic Injury in the Preterm Brain: What Have We Learned from the Animal Model
Daniel Surbek, MD

3:00 p.m. – 3:30 p.m.

Antibiotic Treatment of Infection-associated Preterm Birth and Perinatal Brain Injury
Meredith Kelleher, PhD

3:30 p.m. – 4:00 p.m.

Role of Stem Cell‚Äźderived miRNA Containing Exosomes and Preimplantation Factor (sPIF) in Peripartum Neuroregeneration
Martin Mueller, MD, PhD

Pregnancy Interventions and Outcomes in Vulnerable Populations 
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderators:
Roger Smith, MBBS, PhD
Stephen Matthews, PhD

SAPPHIRE 400 AB

2:00 p.m. – 2:30 p.m.

Improving Outcomes Through Nurturing Care
Stephen Lye, PhD

2:30 p.m. – 3:00 p.m.

Pre-conceptual Interventions to Improve Child Health Outcomes in India
Caroline Fall, MBChB, DM, FRCP, FRCPCH

3:00 p.m. – 3:30 p.m.

Cultural Approaches and their Outcome in a Longitudinal Pregnancy Cohort with Indigenous Australians: Gomeroi gaaynggal
Kym Rae, PhD

3:30 p.m. – 4:00 p.m.

Placental Consequences of Diet Westernization Among Alaskan Natives
Kent Thornburg, PhD

4:00 p.m. - 4:30 p.m.

Coffee Break

SAPPHIRE WEST FOYER

4:30 p.m. - 6:00 p.m.

Concurrent Oral Presentations III

Various

Epidemiology and Global Health
Moderators:
Janet M. Catov, PhD, MS
Angela Kelley, MD

AQUA D

4:30 pm. – 4:45 p.m.

Early-Pregnancy Inflammatory Markers and Preterm Birth Classified According to Placental Features
Baiyang Sun, Marnie Bertolet, Hyagriv N. Simhan, W. Tony Parks, Janet M. Catov

4:45 p.m. – 5:00 p.m.

Demographic Characteristics and Outcomes of Pregnancies among Homeless Women in California
Ariana M. Spiegel, Lillian Sie, Katie B. Sherwin, Brad S. St. Martin, Anna I. Girsen, Gary M. Shaw, Henry C. Lee, Yasser Y. El-Sayed

5:00 p.m. – 5:15 p.m.

Osteoarthritis and Reproductive History in the Women’s Health Initiative
Ange Wang, Nadine Zawadzki, Haley Hedlin, Manisha Desai, Lynn Westphal, Marcia L. Stefanick

5:15 p.m. – 5:30 p.m.

The Association of Income and Race with Inflammation Patterns during Pregnancy
Lauren Keenan-Devlin, Gregory Miller, William Grobman, Emma Adam, Jen Culhane, Pathik Wadhwa, Doug Williamson, Hy Simhan, Kristine Kuchta, Ann Borders

5:30 p.m. – 5:45 p.m.

No Uptake of Maternity Care is Associated with Low Socioeconomic Status and Higher Maternal Health Care Expenses in the First Year after Childbirth
Jacqueline Lagendijk, Eric A Steegers, Jasper V Been

5:45 p.m. – 6:00 p.m.

Maternal Education Level and Risk of Adverse Perinatal Complications in Adolescent Pregnancies
Christina A. Penfield, Deborah A. Wing, Megan Oakes, Aaron B. Caughey

Fetus II
Moderators:
Elsje C. Oostingh, MD
Charles E. Wood, PhD

AQUA AB

4:30 p.m. – 4:45 p.m.

Myoblast Proliferation, Differentiation, Fusion into Myonuclei Are Reduced in the Skeletal Muscle of Intrauterine Growth Restricted Fetal Sheep
Eileen I. Chang, Leanna M. Nguyen, Stephanie R. Wesolowski, Paul J. Rozance, William W. Hay, Jr., Laura D. Brown

4:45 p.m. – 5:00 p.m.

Weak Cardiovascular Defence to Hypotensive Stress in the Chronically Hypoxic Fetus
Beth J. Allison, Kirsty L. Brain, Youguo Niu, Andrew D. Kane, Emilio A. Herrera, Kimberley J. Botting, Christine M. Cross, Nozomi Itani, Katie L. Skeffington, Dino A. Giussani

5:00 p.m. – 5:15 p.m.

Effect of Sildenafil and Nifedipine on Placental Hemodynamics during Hypoxemia in a Chronic Sheep Model
Leena Alanne, Amarnath Bhide, Juulia Junno, Heikki Huhta, Merja Kokki, Mervi Haapsamo, Ganesh Acharya, Juha Räsänen

5:15 p.m. – 5:30 p.m.

Ex Vivo Peroxisome Proliferator-Activated Receptor Gamma Activation Opposes Increased Vasoconstriction in Uterine Artery from High Altitude-Exposed Pregnant Mice
Sydney L. Coates, Ramon A. Lorca, Lorna G. Moore, Colleen G Julian

5:30 p.m. – 5:45 p.m.

Administration of Magnesium Sulfate Inhibits LPS-Induced IL-1β Expression through P2X7 Receptor in Human Umbilical Vein Endothelial Cells
Han Xie, Maide Ozen, Ghada Al Yousif, Michael W McLane, Julia L. Clemens, Jun Lei, Irina Burd

5:45 p.m. – 6:00 p.m.

Sex-Related Differences in Mitochondrial Function in Offspring Hearts Exposed to Prenatal Hypoxia
Loren P. Thompson, Hong Song

Gynecologic Oncology
Moderators:
Alessandro D. Santin, MD
Jessica Vazquez

SAPPHIRE 410 AB

4:30 p.m. – 4:45 p.m.

Remarkable In Vitro and In Vivo Activity of IMGN853, an Antibody-Drug Conjugate Targeting Folate Receptor Alpha Linked to the Tubulin- Disrupting Maytansinoid DM4, in Biologically Aggressive (Type II) Endometrial Cancers
Gary Altwerger, Elena Bonazzoli, Stefania Bellone, Tomomi Egawa-Takata, Gulden Menderes, Francesca Pettinella, Francesco Riccio, Jacqueline Feinberg, Luca Zammataro, Chanhee Han, Ghanshyam Yadav, Katherine Dugan, Ashley Morneault, Jose F. Ponte, Natalia Buza Pei Hui Serena Wong Babak Litkouhi Elena Ratner Dan-Arin Silasi Gloria S. Huang Masoud Azodi Peter E. Schwartz and Alessandro D. Santin

4:45 p.m. – 5:00 p.m.

Co-Occurrence of Somatic Mutations in Tumor Suppressor ARID1A and Estrogen Receptor Cofactor NRIP1 in Endometrial Cancer
Zhigui Li, Oloruntoba I. Osagie, Gary L. Goldberg, Gloria S. Huang

5:00 p.m. – 5:15 p.m.

Integrative Analysis of Multi-Omics Exosomal Data for Identifying Multi-Markers for Susceptibility to Chemotherapy in Ovarian Cancer
Mona Alharbi, Andrew Lai, Dominic Guanzon, Shayna Sharma, Carlos Palma, Felipe Zuñiga, Gregory E. Rice, Lewis Perrin, John D. Hooper, Carlos Salomon

5:15 p.m. – 5:30 p.m.

AXL Inhibition Improves Chemo Response in Gynecologic Serous Cancers
Katherine Fuh, Jeanne Quinn, Meg Palisoul, Molly Greenwade, Katina Massad, Lei Guo,rea Hagemann, Carolyn McCourt, Premal Thaker, Matt Powell, Dave Mutch

5:30 p.m. – 5:45 p.m.

Deep Immunophenotyping Reveals Unique Immune Signature of Ovarian Cancer Ascites
Jessica Vazquez, Gladys Lopez, Melina Chavarria, Mildred Felder, Arvinder Kapur, Aleksandar K Stanic, Manish Patankar

5:45 p.m. – 6:00 p.m.

Identification of Somatic Genetic Alterations in Ovarian Clear Cell Carcinoma with Next Generation Sequencing
Yusuke Shibuya, Hideki Tokunaga, Bin Li, Jun Yasuda, Nobuo Yaegashi

Gynecology III
Moderators:
Valerie A. Flores, MD
James H. Segars, MD

AQUA C

4:30 p.m. – 4:45 p.m.

PLIN2 Functions as a Novel Linker between Progesterone Signaling and Metabolism in Uterine Leiomyoma Cells
Ijeoma Okeigwe, Serdar Bulun, Ping Yin

4:45p.m. – 5:00 p.m.

IL-1β Stimulates BDNF in Human Endometriosis Stromal Cells: Model for Neuroangiogenesis
Jie Yu, Antonio MC Francisco, Bansari G. Patel, Eric Zou, J. Mark Cline, Sarah L. Berga, Robert N. Taylor

5:00 p.m. – 5:15 p.m.

Rare Synonymous Mutations Show Strong Association with Endometriosis
Hans M. Albertsen, Rakesh Chettier, Kenneth Ward

5:15 p.m. – 5:30 p.m.

Early Life Exposure to Endocrine Disrupting Chemicals Induces Inflammation-Mediated DNA Damage in Myometrial Stem Cells
Hoda E Elkafas, Osama A Badary, Rehab Kamel, Engy M. Elmorsy, Abdeljabar EL Andaloussi, Ayman Al-Hendy

5:30 p.m. – 5:45 p.m.

Dexamethasone Improves Embryo Yield but Not Endometrial Outcomes in a Murine Model of Endometriosis
Dennis T. Fujii, Laurel H Gillette, Sem Chan, Richard O Burney

5:45 p.m. – 6:00 p.m.

Tanshinone IIA Reduces Lesional Growth and the Extent of Fibrosis in a Mouse Model of Deep Infiltrating Endometriosis
Xianjun Cai, Min Luo, Xishi Liu, Sun-Wei Guo

Preeclampsia II
Moderators:
James M. Roberts, MD
Chi Zhou, PhD

AQUA EF

4:30 p.m. – 4:45 p.m.

Molecular and Functional Memory in Human Uterine NK Cells Following Pregnancy
Moriya Gamliel, Debra S. Goldman-Wohl, Ronit Haimov-Kochman, Avraham Nahum, Ofer Mandelboim, Simcha Yagel

4:45 p.m. – 5:00 p.m.

Circulating Microparticle Proteins Differ at 10-12 Weeks Gestation in Pregnancies That Develop Preeclampsia
Thomas Frederick McElrath, David Cantonwine, David Sarracino, Scott Peterman, Brian Brohman, Kevin Rosenblatt

5:00 p.m. – 5:15 p.m.

Paternal Deficiency of Complement Component C1q Leads to Pregnancy-Specific Hypertension and Impaired Maternal Vascular Function: A Unique Pregnancy Model
Robert W. Powers, Judith Brands, Marcia Gallaher

5:15 p.m. – 5:30 p.m.

Hypoxia-Mediated LIN28B Downregulation Contributes to Preeclampsia Pathogenesis by Inhibiting Trophoblast Differentiation and Inducing Inflammation
John Canfield, Sefa Arlier, Ezinne Mong, John Lockhart, Jeffrey VanWye, Ozlem Guzeloglu- Kayisli, Frederick Schatz, Charles J. Lockwood, John Tsibris, Umit A. Kayisli, Hana Totary- Jain

5:30 p.m. – 5:45 p.m.

Enhanced Angiogenic Potential of the Human Placental Microvascular Niche
Yingchun Li, Shuhan Ji, Emily J. Su

5:45 p.m. – 6:00 p.m.

IP-10 Supression by Histone Methylation is Mediated by cAMP and the PRC2 Complex in Uterine Stromal Cells
Michelle Silasi, Yang Yang-Hartwich, Yuan You, Paulomi Aldo, Gil Mor

Reproductive Biology II
Moderators:
Francisco Dominguez, PhD
Ramakrishma Kommagani, PhD

SAPPHIRE 400 AB

4:30 p.m. – 4:45 p.m.

Analysis of the Dynamic Changes in Chromatin Accessibility in Decidualizing Human Endometrial Stromal Cells
Raffaella Lucciola, Pavle Vrljicak, Emma S Lucas, Lauren Lansdowne, Nigel Dyer, Sascha Ott, Jan J. Brosens

4:45 p.m. – 5:00 p.m.

Extracellular Vesicles Secreted by the Human Endometrium Contain Specific DNA Cargo That Might Be Involved in Maternal-Embryonic Communication
David Bolumar, Roberto Alonso, Inmaculada Moreno, María Herrero, Sergio Cabanillas, Felipe Vilella, Carlos Simón

5:00 p.m. – 5:15 p.m.

Regeneration of Endometrial Receptivity by SDF-1 or Bone Marrow Derived Cells in Mice with Thin Endometrium
Kyong Wook Yi, Ramanaiah Mamillapalli, Cagdas Sahin, Shafiq Shaikh, Reshef Tal, Hugh S. Taylor

5:15 p.m. – 5:30 p.m.

Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration
Nuria López-Pérez, Xavier Santamaría, Patricia Díaz-Gimeno, Patricia Sebastian-Leon, Amparo Faus, José Remohí, Antonio Pellicer, Carlos Simón, Irene Cervelló

5:30 p.m. – 5:45 p.m.

CSF3 Impacts Female Fertility; Acting on Both Endometrium and Embryo
Tracey A. Edgell, Jemma Evans, Leah Lazzaro, Kendra Boyes, Meghana Sridhar, Sally Catt, Luk Rombauts, Beverley Vollenhoven, Lois Salamonsen

5:45 p.m. – 6:00 p.m.

Enrichment of Putative Stem/Progenitor Cells from Human Myometrium and Fibroids Using Endometrial Stromal Stem/Progenitor Cell Markers
Amanda Patterson, Jitu George, Anindita Chatterjee, Jose Teixeira

6:00 p.m. - 7:30 p.m.

65th Anniversary President's Address, Awards Ceremony with Wine, Beer and Cheese

SAPPHIRE A - J

Presidential Address 
Sandra Davidge, PhD, SRI President, 2017 - 2018 

Frederick Naftolin Award for Mentorship Award Presentation
Gautam Chaudhuri, MD, PhD 

Lifetime Distinguished Service Award Presentation
John R.G. Challis, PhD FRCOG FRSC 

President’s Achievement Award Presentation
Mana Parast, MD, PhD 

Distinguished Scientist Award Presentation
Lucilla Poston, PhD 

8:00 p.m. - 11:00 p.m.

65th Anniversary Party
A ticketed event hosted at Joe's Crab Shack featuring a performance by the new SRI Band, The Featles

 

Saturday, March 10

7:00 a.m. - 1:00 p.m.

Registration

SAPPHIRE WEST FOYER

8:00 a.m. - 9:00 a.m.

SRI Business Meeting
All SRI members are invited and breakfast will be provided during the meeting
 

SAPPHIRE A - J

9:00 a.m. - 9:30 a.m.

SRI Grant Program Recipients Presentations

SAPPHIRE A - J

SRI Early Career Grant and SRI Bridge Grant

9:00 a.m. - 9:15 a.m.

Glucocorticoid Exposure of the Developing Human Embryo: Reprogramming our Future Generations
Sophie Petropoulos, PhD, 2017 SRI Early Career Grant Recipient 

9:15 a.m. - 9:30 a.m.

VEGF delivery rescues spiral artery remodeling in mouse model of placental insufficiency: investigating potential mechanisms
Terry Morgan, MD, PhD, 2017 SRI Bridge Grant Recipient

9:30 a.m.- 11:30 a.m.

Poster Session III
*Coffee and biscuits will be served
 

SAPPHIRE C - P

11:30 a.m. - 1:00 p.m.

Concurrent Oral Presentations IV

Various

Clinical and Translational Perinatology I
Moderators:
Dilly O. Anumba, MD, FRCOG, LLM
Kathleen A. Pennington, PhD

AQUA AB

11:30 a.m. – 11:45 a.m.

Sex Differences in Mesolimbic Dopamine Signaling in a Mouse Model of Maternal Diet- Induced Obesity
Andrea G. Edlow, Chang Xue, Emmanuel Pothos

11:45 a.m. – 12:00 p.m.

Maternal Diet Modification Restores Placental Blood Flow in a Non-Human Primate Model of Diet-Induced Obesity
Jamie Lo, Matthias Schabel, Victoria Roberts, Antonio Frias

12:00 p.m. – 12:15 p.m.

Maternal Diabetes Suppresses Sox2ot Expression and CRISPR-Cas9 Editing on Sox2ot Gene Promoter Disrupts Its Expression Leading to Neural Tube Defects
Daoyin Dong, E. Albert Reece, Wei-Bin Shen, Peixin Yang

12:15 p.m. – 12:30 p.m.

Artificial Sweeteners during Pregnancy - Impact on Maternal Metabolic Health
Jasmine F. Plows, Anna P. Ponnampalam, Mark H. Vickers, Clare M. Reynolds

12:30 p.m. – 12:45 p.m.

Effects of Paternal BMI on Cord Blood Methylation Patterns: An Epigenome-Wide Association Study
Nudrat Noor

12:45 p.m. – 1:00 p.m.

Aspirin: A Potential for Reducing Intrauterine Growth Restriction in Low-Risk Women
Roxane Handal-Orefice, Maria Andrikopoulou, Stephanie Purisch, Russell Miller, Cynthia Gyamfi-Bannerman

Development Programming II
Moderators:
Dino A. Giussani, PhD, ScD, FRCO
Maria B. Rabaglino, MSc, PhD

SAPPHIRE 410 AB

11:30 a.m. – 11:45 a.m.

Aldosterone Plays an Important Role in the Programming Effects of Antenatal Glucocorticoids in Sheep
Jorge P. Figueroa, Cun Li, Jie Zhang, Peter W. Nathanielsz, Angela G. Massmann

11:45 a.m. – 12:00 p.m.

Vascular Function is Altered via Sex-Specific Mechanisms in Aged Offspring Born from Dams of Advanced Maternal Age
Christy-Lynn M Cooke, Alison S. Care, Raven D. Kirshenman, Anita L. Quon, Jude S. Morton, Sandra T. Davidge

12:00 p.m. – 12:15 p.m.

Role of Nephrogenesis in Developmental Programming of Adult Blood Pressure and Nephron Number
Elizabeth DuPriest, Jessica Hebert, Mayu Morita, Terry K. Morgan

12:15 p.m. – 12:30 p.m.

Neurosteroid Therapy Following Preterm Birth in the Guinea Pig Ameliorates Neurological Impairment
Julia Shaw, Hannah Palliser, Rebecca Dyson, Max Berry, Jonathan Hirst

12:30 p.m. – 12:45 p.m.

Epigenetic DNA Methylation-Mediated Programmed Reduced Neural Stem Cell Proliferation and Differentiation in SGA Offspring
Mina Desai, Guang Han, Michael G. Ross

12:45 p.m. – 1:00 p.m.

Size and Shape of the Baboon Corpus Callosum (CC) is Modified by Poor Maternal Nutrition in a Sex Dependent Manner, Demonstrating Early Aging
Jessica L. Joganic, Ronan Ledevin, Hillary F. Huber, Cun Li, Peter W. Nathanielsz, Geoffrey D. Clarke, Yann Heuze

Parturition III
Moderators:
Jennifer C. Condon, PhD
Kristin Marie Myers, PhD

AQUA C

11:30 a.m. – 11:45 a.m.

Shear Wave Elasticity Imaging Detects Gradual Softening of the Pregnant Rhesus Macaque Cervix
Ivan M. Rosado-Mendez, Lindsey C. Drehfal, Quinton W Guerrero, Andrew P. Santoso, Mark L. Palmeri, Helen Feltovich, Timothy J. Hall

11:45 a.m. – 12:00 p.m.

Proliferative and Migratory Properties Reveals Metastate of Amnion Cells Mediated by Epithelial to Mesenchymal and Mesenchymal to Epithelial Transitions
Lauren Richardson, Jayshil Trivedi, Ramkumar Menon

12:00 p.m. – 12:15 p.m.

A Biomechanical Signature to Assess Cervical Extracellular Components in Term and Preterm Birth
Charles Jayyosi, Nicole Lee, Shanmugasundaram Nallasamy, Alexandra Willcockson, Mala Mahendroo, Kristin Myers

12:15 p.m. – 12:30 p.m.

Oxytocin Inhibits the Potassium Channel SLO2.1: A Novel Mechanism of Regulating Uterine Excitability
Celia M. Santi, Juan J. Ferreira, Alice Buttler, Richard Stewart, Ana Laura González-Cota, Pascale Lybaert, Chinwendu Amazu, Erin L. Reinl, Monali Wakle-Prabagaran, Lawrence B. Salkoff, Sarah K. England

12:30 p.m. – 12:45 p.m.

T Type Ca2+ Channels May Play an Essential Role in Uterine Contractility
Sandy Li, Qunsheng Dai, Chad Grotegut, Thomas Price

12:45 p.m. – 1:00 p.m.

The Efficacy of Aminophylline and Progesterone Co-Treatment to Suppress Human Myometrial Contractions during Prolonged Exposure
Pei F. Lai, Roger C. Young, Rachel M. Tribe, Mark R. Johnson

Placenta II
Moderators:
Vicki L. Clifton, PhD
Jessica F. Hebert, PhD Candidate

AQUA EF

11:30 a.m. – 11:45 a.m.

Gestational Testosterone Excess Compromises Placental Milieu in a Sheep Model of Polycystic Ovary Syndrome
Angela S. Kelley, Muraly Puttabyatappa, Yolanda R. Smith, Vasantha Padmanabhan

11:45 a.m. – 12:00 p.m.

Direct Toxicity of Insulin on the Human Placenta and Protection by Metformin
Mario Vega, Maurizio Mauro, Zev Williams

12:00 p.m. – 12:15 p.m.

Multiparametric High Resolution Flow Cytometry Reveals Upregulation of Platelet-Specific Microvesicles in the First Trimester of Pregnancy
Mayu Morita, Terry Morgan

12:15 p.m. – 12:30 p.m.

Interactions between Placental Exosomes and Skeletal Muscle - Implication in Cell Metabolism in Gestational Diabetes Mellitus
Soumyalekshmi Nair, Nanthini Jayabalan, Dominic Guanzon, Andrew Lai, Katherin Scholz- Romero, Omar Elfeky, Felipe Zuñiga, Emilio Diaz, David McIntyre, Gregory E. Rice, Martha Lappas, Carlos Salomon

12:30 p.m. – 12:45 p.m.

Hydroxychloroquine Treatment Inhibits ZIKV Infection in Placenta by Blocking ZIKV NS2B-NS3 Protease Activity
Brooke Liang, Ankur Kumar, Rajanish Giri, Indira U. Mysorekar

12:45 p.m. – 1:00 p.m.

Human Decidual Cells (DCs) Express Proteins Required for ZIKA Virus (ZIKV) Cell Entry and Are Permissive for ZIKV Infection
Ozlem Guzeloglu-Kayisli, Nihan Semerci, Kellie Larsen, Catherine Elzein, Frederick Schatz, Umit Kayisli, Charles Lockwood

Regenerative Medicine
Moderators:
Valerie A. Flores, MD
Mana M. Parast, MD, PhD

SAPPHIRE 400 AB

11:30 a.m. – 11:45 a.m.

PreImplantation Factor Promotes Neuroprotection by Modulating Long Non-Coding RNA H19 of the Neuronal Stem Cells
Martin Mueller, Marialuigia Spinelli, Sara Ornaghi,reina Schoeberlein, Angelique Bordey, Daniel Surbek, Eytan Barnea, Michael Paidas

11:45 a.m. – 12:00 p.m.

Bone-Marrow Derived Endometrial Cells Express Glucocorticoid Receptor
Kavitha Krishnamoorthy, Amma Owusu-Akyaw, Laura T. Goldsmith, Sara S. Morelli

12:00 p.m. – 12:15 p.m.

Fertility Rescue by Bone Marrow Derived Stem Cell Infusion
Anna Buigues, Sonia Herraiz, Maria Marchante, Aaron J Hsueh, Antonio Pellicer

12:15 p.m. – 12:30 p.m.

Endometrial Mesenchymal Stromal/Stem Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice
Saeedeh Darzi, James A Deane, Claudia Nold, Sharon L. Edwards, Shayanti Mukherjee, Shanti Gurung, Ker Sin Tan, Jerome A. Werkmeister, Caroline E. Gargett

12:30 p.m. – 12:45 p.m.

Human Amniotic Fluid Stem Cells: A Novel Treatment Option for Neonatal Cerebral Palsy
Toshimitsu Otani, Daigo Ochiai, Marie Fukutake, Yushi Abe, Yu Sato, Youhei Akiba, Tadashi Matsumoto, Hirotaka Masuda, Kei Miyakoshi, Mamoru Tanaka

12:45 p.m. – 1:00 p.m.

Maintenance of Undifferentiated Human Endometrial Mesenchymal Stem Cells by TGFβ Receptor Inhibition Reveals an Angiogenic and Anti-Inflammatory Phenotype
Shanti Gurung, Sarah Williams, Jerome A Werkmeister, Caroline E. Gargett

Reproductive Endocrinology And Infertility II
Moderators:
Irene Cervello, PhD
Maria D. Salazar Garcia, MD

AQUA D

11:30 a.m. – 11:45 a.m.

MFN1 is Required for Follicle Development, Oocyte Maturation, Female Fertility
Man Zhang, Tianren Wang, Muhammed Burak Bener, Ecem Esencan, Richard Scott III, Emre Seli

11:45 a.m. – 12:00 p.m.

Human Adipose Derived Stem Cells Improve Growth and Survival of Murine Primary Follicles in a Biomimetic Culture System
Elizabeth S Constance, Claire E. Tomaszewski, Hong Zhou, Ariella Shikanov

12:00 p.m. – 12:30 p.m.

High Number of Ovarian Follicles Maintained after Ovarian Tissue Cryopreservation in Young Females with Cancer Requiring Gonadotoxic Treatment
Mindy S. Christianson, Jacqueline Y. Maher, Erik W. Jenson, Qihong Wang, Jeffrey Lukish

12:15 p.m. – 12:30 p.m.

A Cargo of Amplifiable Genomic DNA is Present in Human Preimplantation Embryo-Exported Extracellular Vesicles and Assessable for Mutation Detection
Sofia Makieva, Francesca Spinella, Elisa Giacomini, Laura Corti, Anil Biricik, Francesco Fiorentino, Paola Viganò

12:30 p.m. – 12:45 p.m.

Human Embryo Secretions Regulate Human Endometrial Adhesion via the Lnc RNA, PTENP1’s, Sponge Effect on Endometrial MicroRNA
Masashi Takamura, Kate Rainczuk, Carly Cuman, Luk Rombauts, Tiki Osianlis, Evdokia Dimitriadis

12:45 p.m. – 1:00 p.m.

Plasma microRNAs Identified as Novel Markers of Embryo Implantation
Shirin Khanjani, Rumana Islam, Javairia Khalid, Vasso Terzidou, Stuart Lavery, Kim Sung Hye, Phillip R Bennett

1:00 p.m. - 3:00 p.m.

Hot Pizza and Hot Topics, Awards Luncheon

SAPPHIRE A - J