Detailed Program

Registration 

Registration

8:30 a.m. - 12:00 p.m.

Satellite Meetings

VARIOUS ROOMS

1:15 p.m. - 4:30 p.m.

Satellite Meetings

VARIOUS ROOMS

5:00 p.m. - 5:20 p.m.

Presidential Address

Salon E-F

5:25 p.m. - 6:00 p.m.

March of Dimes Developmental Biology Prize Presentation and Lecture

Susan Fisher, PhD
University of California, San Francisco

The March of Dimes and Richard B. Johnston, Jr., MD Prize in Developmental Biology honors an outstanding scientist who has profoundly advanced the science that underlies our understanding of pregnancy, parturition and prenatal development. The Prize is sponsored by the Society for Reproductive Investigation, whose mission to advance reproductive and women’s health care through outstanding basic, translational and clinical science and by training and mentoring future generations of investigators complements March of Dimes’ work to support healthy moms and strong babies. The recipients of the Prize are leaders in reproductive biology working on translational and actionable science that can develop into interventions or preventions that will improve the health of moms and babies everywhere.

Salon E-F

6:00 p.m. - 7:00 p.m.

President's New Investigator Plenary
Supported by the Past Presidents' Fund

Salon E-F

7:00 p.m. - 7:30 p.m

Awards Ceremony

Salon E-F

7:30 p.m. - 8:30 p.m.

Welcome Reception

3rd Floor Atrium

Registration

8:00 a.m. - 10:00 a.m.

Concurrent Oral Presentations I

Clinical and Translational Perinatology I
Moderators:
Annie Dude, MD
Ira Bernstein, MD

Salon AB

8:00 a.m. - 8:15 a.m.

O-005: Molecular Mechanisms Underlying Selective Sorting of MiRNAs into Small Extracellular Vesicles in Placental Cells in Gestational Diabetes Mellitus (GDM)
Soumyalekshmi Nair, Andrew Lai, Nanthini Jayabalan, Dominic Guanzon, Katherin Scholz-Romero,David McIntyre, Martha Lappas, Carlos Salomon

8:15 a.m. - 8:30 a.m.

8:30 a.m. - 8:45 a.m.

O-007: Metabolomic Signatures of Low and High Adiposity Neonates Differ Based on Maternal BMI
Begum Aydogan Mathyk, Brian Piccolo, Kartik Shankar, Perrie O'Tierney-Ginn

8:45 a.m. - 9:00 a.m.

O-008: Adult Offspring of Obese Mice Have Reduced Resistance Artery Vasodilator Responses
Ramón A Lorca, Julie A Houck, Jerad H Dumolt, Owen R Vaughan, Kelsey Barner, Theresa L Powell, Thomas Jansson, Lorna G Moore, Colleen G Julian

9:00 a.m. - 9:15 a.m.

O-009: The Impact of Pre-Pregnancy Maternal Lipid Metabolism on Neonatal Adiposity
Raziel Rojas-Rodriguez, Patrick M Catalano

9:15 a.m. - 9:30 a.m.

O-010: Highly Atherogenic Lipid Particles Are Associated with Preeclampsia (Pre-E) in Obese Women with Unexplained Infertility Who Conceived during Ovarian Stimulation with Intrauterine Insemination (OS-IUI)
Robert A Wild, Rodney K Edwards, David S Wrenn, Yan D Zhao, Karl R Hansen

9:30 a.m. - 9:45 a.m.

O-011: Frequency and Correlates of Severe Chronic Hypertension (CHTN) 5 - 7 Years after Pregnancy Complicated by Mild CHTN
Ayamo Gina Oben, Jeff Szychowski, Rachel Sinkey, Peter Ketch, Cooper Elkins, William Andrews, Alan Tita

9:45 a.m. - 10:00 a.m.

O-012: A Prognostic Model for Early Risk Stratification of Spontaneous Preterm Birth
Anadeijda Landman, Marjon de Boer, Marije Lamain-de Ruiter, Martijn Heymans, Arie Franx, Martijn Oudijk, Mireille Bekker, Wendy Koster

Gynecology I
Moderators:
Bo Rueda, PhD
Shannon Whirledge, PhD, MSc

Salon CD

8:00 a.m. - 8:15 a.m.

O-013: Loss of MIG-6 Results in Endometrial Progesterone Resistance and Endometriosis-Related Infertility through ERBB2 Overexpression
 Tae Hoon Kim, Jung-Yoon Yoo, Jung-Ho Shin, Ryan Marquardt, Ulrich Müller, Asgerally Fazleabas, Steven Young, Bruce Lessey, Ho-Geun Yoon, Jae-Wook Jeong

8:15 a.m. - 8:30 a.m.

O-014: The Role of ARID1a in Mediating Endometriosis Disease Progression
Valerie Flores, Tran Dang, Jing Ji, Gloria Huang, Hugh S Taylor

8:30 a.m. - 8:45 a.m.

O-015: Endometriosis Is a Possible Risk Factor for Premature Cardiovascular Disease
Jessica N Blom, Maria P Velez, Chad McClintock, Jessica Pudwell, Susan Brogly, Olga Bougie

8:45 a.m. - 9:00 a.m.

O-016: Randomized, Placebo-Controlled Trial of Botulinum Toxin for Endometriosis-Associated Chronic Pelvic Pain: A Longitudinal Assessment
Pamela Stratton, Hannah K Tandon, Vy Phan, Jacqueline V Aredo,, Ninet Sinaii, Jay P Shah, Barbara I Karp

9:00 a.m. - 9:15 a.m.

O-017: Bleeding Patterns in Women with Endometriosis-Associated Pain Treated with Relugolix Combination Therapy: SPIRIT Program
Andrea S Lukes, Sawsan As-Sanie, Christian M Becker, Mauricio S Abrao, Claudia Mehedintu, Galyna Reznichenko, Linda Giudice, Furong Wang, Viatcheslav G Rakov, Qurratul A Warsi

9:15 a.m. - 9:30 a.m.

O-018: Single-Cell Sequencing Reveals Novel Cell Type and Heterogeneous Non-Monoclonal Cell Populations in Human Leiomyomas
Jyoti Goad, Joshua Rudolph, Jian-Jun Wei, Serdar E Bulun, Debabrata Chakravarti, Aleksandar Rajkovic

9:30 a.m. - 9:45 a.m.

O-019: Long Noncoding RNA MIAT Modulates the Extracellular Matrix Deposition in Leiomyomas via Sponging MiR-29 Family
Tsai-Der Chuang, Derek Quintanilla, Drake Boos, Omid Khorram

9:45 a.m. - 10:00 a.m.

O-020: Reduction in Menstrual Blood Loss in Patients Treated with Relugolix Combination Therapy: LIBERTY Long-Term Extension Study
Ayman Al-Hendy, Andrea S Lukes, Alfred Poindexter III, Roberta Venturella, Claudio Villarroel, Rachel B Wagman, Yulan Li, Elizabeth A Stewart, Laura McKain

Parturition I
Moderators:
Leslie Myatt, PhD, FRCOG
Michal Elovitz, MD

Salon HI

8:00 a.m. - 8:15 a.m.

O-021: Upregulation of miR-877-3p and Downregulation of miR-186-3p in the Placentas of Patients with Idiopathic Preterm Birth
Duygu Mutluay, Xiaofang Guo, Ozlem Guzeloglu Kayisli, Frederick Schatz, Umit Kayisli, Charles Lockwood

8:15 a.m. - 8:30 a.m.

O-022: Iron-Dependent Apoptosis Causes Embryotoxicity in Inflamed and Obese Pregnancy
Allison L Fisher, Veena Sangkhae, Tomas Ganz, Elizabeta Nemeth

8:30 a.m. - 8:45 a.m.

O-023: A Broad Spectrum Chemokine Inhibitor Prevents Infection-Induced Myometrial Inflammation and Activation
Adam Boros-Rausch, Tsung-Yen Wu, Kristina Adams Waldorf, Oksana Shynlova, Stephen Lye

8:45 a.m. - 9:00 a.m.

O-024: Exposure to Experimental Fetal Inflammatory Response Syndrome Results in IL-6 Dependent Upregulation of Interferon Lambda Expression and Subsequent Loss of Neonatal Paneth Cells
Sarah Nichole Watson, Huiyu Gong, Brian Juber, Steven Mcelroy

9:00 a.m. - 9:15 a.m.

O-025: Establishment of a Mouse Uterine Explant Model to Study Inflammation in Pregnancy and Parturition
Madeline Snedden, Chandrashekara Kyathanahalli, Emmet Hirsch

9:15 a.m. - 9:30 a.m.

O-026: Inflammatory-Related Mir-612 Is Increased in Circulating Exosome-Like Vesicles from Women Undergoing Preterm Birth
 Bruna Ribeiro de Andrade Ramos, Júlia Abbade Tronco, Márcio de Carvalho, Patrícia Pintor dos Reis, Juliano Coelho da Silveira, Márcia Guimarães da Silva

9:30 a.m. - 9:45 a.m.

O-027: Dose-Response Profile of a Novel Anti-Interleukin-1 Therapeutic, Rytvela, for Prevention of Preterm Birth
Tiffany Habelrih, Sarah-Eve Loiselle, France Côté, Xin Hou, Christiane Quiniou, Sylvain Chemtob

9:45 a.m. - 10:00 a.m.

O-028: Placenta Serum Amyloid A-2 (SAA-2) Plays an Important Role in Maternal Inflammation-Induced Adverse Fetal Outcomes
Yang Liu, Jin Liu, Anguo Liu, Irina Burd, Lei Jun

Placenta I
Moderators:
Jessica Hebert. PhD
Emily Su, MD

Salon KJ

8:00 a.m. - 8:15 a.m.

O-029: A Microphysiological Model of Human Trophoblast Invasion during Early Embryo Implantation
Sneha Mani, Ju Young Park, Geremy Clair, Cassidy Blundell, Rachel Young, Jessica Kanter, Scott Gordon, Yoon-Suk Yi, Dan Dongeun Huh, Monica Mainigi

8:15 a.m. - 8:30 a.m.

O-030: The Utero-Placental Vascular Skeleton: A New Image Processing Technique to Estimate Utero-Placental Vascular Morphologic Development and the Association with Maternal Hemodynamic Adaptation to Pregnancy
Eline S de Vos, Anton HJ Koning, Régine PM Steegers-Theunissen, Sten P Willemsen, Bas B van Rijn, Eric AP Steegers, Annemarie GMGJ Mulders

8:30 a.m. - 8:45 a.m.

O-031: Placental Cell-Specific Extracellular Vesicle Profiles from Syncytiotrophoblasts and Extravillous Trophoblasts in the First Trimester
Terry Morgan, Mayu Morita, Leslie Myatt

8:45 a.m. - 9:00 a.m.

O-032: Impaired Cell Polarity and Bi-Directional Endothelial Cell-Matrix Interactions Mediate Disrupted Fetoplacental Angiogenesis
Shuhan Ji, Diane Gumina, Emily J Su

9:00 a.m. - 9:15 a.m.

O-033: Activation of Amnion Signaling during Intrauterine Inflammation Is TNF-Dependent
Pietro Presicce, M Cappelletti, M Morselli, P Senthamaraikannan, L Miller, M Pellegrini, A Jobe, C Chougnet, S Kallapur

9:15 a.m. - 9:30 a.m.

O-034: Role of GATA2 and GATA3 in Syncytiotrophoblast Development during Mammalian Placentation
Ananya Ghosh

9:30 a.m. - 9:45 a.m.

O-035: Females Are Not Just ‘Protected’ Males: Sex-Specific Vulnerabilities in Placenta and Brain after Prenatal Immune Disruption
Amy E Braun, Pamela A Carpentier, Brooke A Babineau, Aditi R Narayan, Michelle L Kielhold, Hyang Mi Moon, Jennifer Su, Vidya Saravanapandian, Theo D Palmer

9:45 a.m. - 10:00 a.m.

O-036: Derivation of Human Trophoblast Stem Cells from Pluripotent Stem Cells to Model Early Placental Development
Francesca Soncin, Mariko Horii, Rob Morey, Tony Buy, Daniela Requena, Virginia Chu Cheung, Omar A Farah, Don Pizzo, Mana M Parast

Maternal Biology and Health
Moderators:
Elizabeth Bonney, MD
Anna Powell, MD

Wellesley

8:00 a.m. - 8:15 a.m.

O-037: Percutaneous Electrical Stimulation of Skeletal Muscle Attenuates Insulin Resistance in Pregnant Rats with Diet-Induced Obesity
David Coggin-Carr, Keara McElroy-Yaggy, Paul D Taylor, Anna L David, Elisabet Stener-Victorin, Tom Jetton

8:15 a.m. - 8:30 a.m.

O-038: Seasonality and the Immune System during Pregnancy: Impact of Seasonal Affective Disorder
Cindy Xin Wen Zhang, Robert Levitan, Stephen Matthews

8:30 a.m. - 8:45 a.m.

O-039: Estradiol Stimulates Pregnancy-Dependent H2S Biosynthesis in Human Uterine Artery Endothelial Cells via ERα/ERβ-Mediated Upregulation of CBS Transcription
Jin Bai, Thomas J Lechuga, Qian-rong Qi, Yi-hua Yang, Quan-wei Zhang, Yan Li, Dong-bao Chen

8:45 a.m. - 9:00 a.m.

O-040: Placental MiRNAs Predicted to Target Insulin Signaling Pathways Are Associated with Maternal Insulin Resistance in Late Pregnancy
Fernanda L Alvarado Flores, William Beyer, Tomoko Kaneko-Tarui, Tianjiao Chu, Yoel Sadovsky, Patrick Catalano, Perrie O’Tierney-Ginn

9:00 a.m. - 9:15 a.m.

O-041: Clot Formation Potential in the Late Pregnant and Postpartum Woman
Elizabeth Barker, Ira Bernstein, Thomas Orfeo, Kelley McLean, Maria Cristina Bravo

9:15 a.m. - 9:30 a.m.

O-042: Identification and Isolation of Rare Microchimeric Cells in Maternal and Cord Blood.
Whitney Harrington, Yonghou Jiang,  Whitney Harrington, John Houck, Marc Carlson, Stephen McCartney, Kelsey Olerich, Sami B Kanaan, J Lee Nelson, Raj Shree

9:30 a.m. - 9:45 a.m.

O-043: Women with Adverse Pregnancy Outcomes Have Higher Risk of Midlife Stroke: The PATH Study.
Eliza C Miller, Natalie A Bello, Rindcy Davis, Alexander M Friedman, Mitchell SV Elkind, Ronald Wapner, Sarah E Tom

9:45 a.m. - 10:00 a.m.

O-044: Isolating Mechanisms on Future Cardio-Renal Risk in Mothers with Complicated Pregnancy
Kimberley J Botting, Wen Tong, Youguo Niu, Tessa A Garrud, Lin Zhang, Sage G Ford, Qiang Lyu, Olga V Patey, Dino A Giussani

Reproductive Biology I
Moderators:
Erica Marsh, MD, MSCI, FACOG
John Davis, MD

Suffolk

8:00 a.m. - 8:15 a.m.

O-163: Plasma Enriched in Stem Cell Secreted Factors Improves Ovarian Function in a Mouse Model of Advanced Maternal Aged.
Maria Marchante, Anna Buigues, Jessica Martinez, Antonio Pellicer

8:15 a.m. - 8:30 a.m.

O-046: Screening Putative Haplo-Essential Translation Genes for Contribution to Early Reproductive Failure
Luwam Ghidei, Denise Lanza, Lauryl M J Nutter, Pilar Cacheiro, Violeta Munoz-Fuentes, Jason Heaney

8:30 a.m. - 8:45 a.m.

O-047: Elucidating the Role of FOXO3 in Regulating Ovarian Reserve and Function in Humans
Caterina Clementi, Karen Hunter Cohn, Genevieve Galarneau, Piraye Yurttas Beim

8:45 a.m. - 9:00 a.m.

O-048: Loss of Ovarian Expression of the Noncoding RNA H19 Promotes Susceptibility to Doxorubicin-Induced DNA Damage
Amanda N Kallen, Pingping Lu, Jing Wang, Joshua Johnson

9:00 a.m. - 9:15 a.m.

O-049: Novel Anti-Mullerian Hormone Receptor 2 Binding Peptide (AMHR2BP) Modulates Oocyte Function In Vivo
Laura Detti, Ghassan M Saed

9:15 a.m. - 9:30 a.m.

O-050: Aneuploidy in Human Embryos May Elicit a Premature Differentiation Response in the Inner Cell Mass
Angel Martin, Francisco Dominguez, Alicia Quiñonero, Carmina Vidal, Amparo Mercader, Fernanda Insua, Maria Jose De los Santos

9:30 a.m. - 9:45 a.m.

O-051: Bromodomain Extraterminal (BET) Family Inhibitor JQ1 Inhibits Nuclear Maturation and Cytoplasmic Organization of Oocytes
Keerthana Karunakar Poojary, Sandhya Kumari, Satish K Adiga, Guruprasad Kalthur

9:45 a.m. - 10:00 a.m.

O-052: Opposite Effects of LH/PKA/MTOR and AMPK Signaling on Induction of Autophagy in Luteal Cells
Emilia Przygrodzka, Michele R Plewes, Guojuan Li, John S Davis

10:00 a.m. - 10:30 a.m.

Coffee Break

Level 3 Foyer & Level 4 Grand Ballroom Foyer

10:30 a.m. - 12:30 p.m.

Mini-Symposia I

Stem Cell Therapy of Reproductive Disorders
*Interactive Session
Moderators: 
Ayman Al-Hendy, MD, PhD
Sonia Herrais, PhD

Salon AB

Opportunities and Challenges in Regenerative Therapies
Sonia Herriaz, PhD

Stem Cell and Gene Therapy of Ovarian Infertility: from Bench to Rodents to Women, and Back
Ayman Al-Hendy, MD, PhD

Cell Therapy of Asherman Syndrome and Endometrial Atrophy
Carlos Simon, MD, PhD

Stem cell therapies for male infertility: ready for the clinic
Kyle Orwig, PhD

Session Q&A

Pregnancy – A Lost Opportunity to Screen
Moderators: 
Sandy T. Davidge, PhD, FCAHS
Laura A. Magee, MD, FRCPC, MSc, FACP, FRCOG

Salon CD

10:30 a.m. - 10:55 a.m.

Pregnancy Complications and the Life Course – Implications for the Child
Lucilla Poston, PhD

10:55 a.m. - 11:20 a.m.

Placental Insufficiency and Impact on Fetal Development
Emily J. Su, MD

11:20 a.m. - 11:45 a.m.

Adverse Pregnancy Outcomes Screening and Long Term Maternal Health
Fergus McCarthy, MSc, PhD

11:45 a.m. - 12:10 p.m.

Patient-Reported Outcomes and the Feasibility of Tracking Long-Term Cardiovascular Disease Outcomes – The Preeclampsia Foundation Registry
Mayri Leslie

12:10 p.m. - 12:30 p.m.

Session Q&A

Salon HI

10:30 a.m. - 10:55 a.m.

Implications of Immunoperinatology Research on Neonatal and Lifetime Health
Maide Ozen, MD

10:55 a.m. - 11:20 a.m.

Multidisciplinary, Multiplatform Approaches to Unravel the Mechanisms of Adverse Pregnancy Outcomes
Nima Aghaeepour, PhD

11:20 a.m. - 11:45 a.m.

Next Frontiers in Vesicle-Based Placental-Maternal-Fetal Communication
Yoel Sadovsky, MD

11:45 a.m. - 12:10 p.m.

Gaps in Knowledge in Understanding the Immunobiology and Immunopathology of Pregnancy and Future Directions
Ana Claudia Zenclussen, PhD

12:10 p.m. - 12:30 p.m.

 Session Q&A

Salon KJ

10:30 a.m. - 10:55 a.m.

Understanding Aneuploidy
Pat Hunt, PhD

10:55 a.m. - 11:20 a.m.

Developmental Potential of Aneuploid Human Embryos Beyond Implantation
Magdalena Zernicka-Goetz, PhD

11:20 a.m. - 11:45 a.m.

Assessment of Aneuploidy and Mosacisim in Human Embryos: Promises and Pitfalls of Molecular Approaches and Study Designs
Richard T. Scott Jr., MD

11:45 a.m. - 12:10 p.m.

New Insights From Clinical NIPT Data Regarding Human Aneuploidy and Mosaicism
Diana W. Bianchi, MD

12:10 p.m. - 12:30 p.m.

 Session Q&A

Wellesley

10:30 a.m. - 10:55 a.m.

Endometriosis Biomarkers
Hugh S. Taylor, MD

10:55 a.m. - 11:20 a.m.

Discovery of Extracellular RNA Biomarkers for Prediction of Preeclampsia
Louise Laurent, MD, PhD

11:20 a.m. - 11:45 a.m.

Selecting the most viable embryo: Towards Non-Invasive Technologies
Denny Sakkas, PhD

11:45 a.m. - 12:10 p.m.

Novel Mechanisms and Potential Targets in Preterm Labor and Birth
Nardhy Gomez-Lopez, PhD

12:10 p.m. - 12:30 p.m.

 Session Q&A

Suffolk

10:30 a.m. - 10:55 a.m.

In Vivo Imaging of Reproductive Dynamics in the Mouse Oviduct
Shang Wang, PhD

10:55 a.m. - 11:20 a.m.

Active Fluctuations Modulate Nuclear Dynamics in Oocytes
Marie-Helene Verlhac, PhD

11:20 a.m. - 11:45 a.m.

Quantitative Ultrasound of the Cervix in Pregnancy: Today & Tomorrow
Helen Feltovich, MD

11:45 a.m. - 12:10 p.m.

Preventing Postpartum Depression: An Intergenerational fMRI Clinical Trial
Kristen Mackiewicz Seghete, PhD

12:10 p.m. - 12:30 p.m.

 Session Q&A

12:45 p.m. - 1:45 p.m.

Lunch and Learn Symposium I 
*Boxed lunches are available and complimentary through the Registration Deadline only.

Big Data and the Impact on Scientific Success
Moderator:
Aleksandar Stanic, MD, PhD

Salon AB

Introduction to Big Data Analysis
Piraye Yurttas Beim, PhD

1:00 p.m. - 1:15 p.m.

Multi-Omics Approach in Uterine Fibroids Research
Benedikt Kessler, PhD

1:15 p.m. - 1:30 p.m.

Systems Biology Study to Puzzle out Preterm Birth with an Integrated-Omics Approach
Nanbert Zhong, MD, PhD 

1:30 p.m. - 1:45 p.m.

Session Q&A

12:45p.m. - 1:45 p.m.

Lunch and Learn Symposium II 
*Boxed lunches are available and complimentary through the Registration Deadline only.

NIH and Reproductive Medicine
Moderators: 
Irina Burd, MD, PhD​
Emre Seli, MD

Salon CD

NICHD Strategic Planning Update
Diana Bianchi, MD

1:00 p.m. - 1:15 p.m.

Strategies for Obtaining NIH Extramural Funding
Lisa Halvorson, MD

1:15 p.m. - 1:30 p.m.

Life as an Intramural NIH Researcher
Alan DeCherney, MD

1:30 p.m. - 1:45 p.m.

Session Q&A

2:00 p.m. - 3:30 p.m.

Concurrent Oral Presentations II

 Developmental Programming I
Moderators:
Stephen A. Contag, MD
Terry K. Morgan, MD, PhD

Salon AB

O-053: Epigenetic Effects of N-acetylcysteine on H₂S-Mediated Protection Against Fetal Origins of Vascular Disease.
A A Paz, T A Garrud, E Peñaloza, F Vega-Tapia, S G Ford, Y Niu, B J Krause, D A Giussani

O-054: Placental Endocrine Malfunction Causes Sex Specific Changes in Metabolic Organs of Fetal and Adult Mouse Offspring
Efthimia Christoforou,  Panayiotis Laouris, Jorge Lopez-Tello, Marta Ibanez Lligona, Hannah Yong, Alison Forhead, Amanda Sferruzzi-Perri

O-055: Maternal Obesity Upregulates Fetal Heart Pparg Expression with Consequences for Later Life Cardiac Metabolic and Contractile Function in Mice
O R Vaughan, J Chan, L Cox, V Ferchaud-Roucher, F Rosario, J EB Reusch, A C Keller, T L Powell, T Jansson

O-056: Defining the Role of the Hypothalamic Pituitary Adrenal Axis in the Relationship between Fetal Growth and Adult Cardiometabolic Outcomes
Wrivu N Martin, Carol A Wang, Stephen J Lye, Rebecca M Reynolds, Stephen G Matthews

O-155: Zika Virus Vertical Transmission Dynamics in the
Pregnant Rhesus Macaque
Michelle R Koenig, A Mitzey, L T Keding, T A Treadway, H Simmons, A Mejia,
M I Bliss, A M Weiler, T Friedrich, X Zeng, D H O’Connor, E L Mohr, T G Golos

O-156: Tracking Postnatal Behavioral Outcomes in a Novel Mouse Model of
CongenitalCMV Infection
Gregory Wohl Kirschen, Anguo Liu, Yang Liu, Ashley Coggins, Jun Lei, Karen
Racicot, Andrew Thagard, Irina Burd

Fetus I
Moderators:
Karin Blakemore, MD
Jun Lei, MD

Salon CD

O-057: Hypoxemia Prevents Insulin Mediated Suppression of Gluconeogenic Gene Expression in the Fetal Liver during Hypoglycemia
Priya Mukherjee, Amanda Jones, Paul Rozance, Brown Laura, Sean Limesand, Stephanie Wesolowski

O-058: Maternal Obesity Induces Fetal Sheep Hepatic Oxidative Stress (OS) and Mitochondrial Damage Predominantly in the Right Lobe
Susana P Pereira, Luis F Grilo, Mariana S Diniz, Carolina Tocantins, João D Martins, Stephen Ford, Peter W Nathanielsz, Paulo J Oliveira

O-059: Impaired Autonomic Control of Heart Rate Variability during Acute Stress in the Chronically Hypoxic Fetus
N Hafiz, B J Allison, N Itani, K J Botting, Y Niu, C C Lees, C J Shaw, D A Giussani

O-060: RNAseq of Amniotic Fluid Reveals Activation of the Innate Immune Response and Differential Expression of Brain Transcripts in Fetuses with Cytomegalovirus Infection
Lisa Hui, Luc de Catte, Neeta Vora, Sally Beard, Jovana Maksimovic, Alicia Oshlac, Susan P Walker, Natalie Hannan

O-061: Uterine Fibroids Associated with Lower Fetal Fraction and Indeterminate NIPS Results in Non-Obese Subjects
Teodora Kolarova, Hayley MacKinnon, Jaclynne Hedge, Christina Lockwood, Raj Shree

O-062: Cervical Gene Delivery of the Antimicrobial Peptide Human β Defensin 3 (HBD3) Reduces Perinatal Neuroinflammation in a Mouse Model of Ascending Infection-Associated Preterm Birth
Ashley K Boyle, Natalie Suff, Simon N Waddington, Donald Peebles

Preeclampsia I
Moderators:
Virginia D. Winn, MD, PhD
Jessica Hebert, PhD

Salon HI

O-063: Functional Enrichment Analysis of Differentially Expressed Transcripts/Genes of Medium/Large STBEVs Identified Potentially Dysregulated Pathways in Early Onset Preeclampsia (EOPE)
Toluwalase Awoyemi, Adam Cribbs, Wei Zhang, Chris Redman, Manu Vatish

O-064: Proinflammatory and Anti-Inflammatory Cytokine Responses by Decidua T Cells in Preeclampsia
Ai-ris Yonekura Collier, Dan H Barouch

O-065: Impact of Preeclampsia on Polarization and Functionality of Hofbauer Cells
Monika Horvat Mercnik, Carolin Schliefsteiner, Christian Wadsack

O-066: CD4 T Cells Deficiency Enhances Internal Carotid Artery Constriction in Postpartum Mice: The Role of Nitric Oxide
Natalia I Gokina, Rebecca I Fairchild, Kirtika Prakash, Nicole M DeLance, Elizabeth A Bonney

O-067: Noninvasive Prediction of Preeclampsia in Pregnancy with Circulating RNA
Mira N Moufarrej, Ronald J Wong, Ana A Campos, Cecele C Quaintance, Rene V Sit, Michelle Tan, Norma F Neff, Maurice L Druzin, Virginia D Winn, Gary M Shaw, David K Stevenson, Stephen R Quake

O-068: Circulating SIGLEC6 Is Deranged in Preeclampsia and May Be a Biomarker of Disease Severity
Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Teresa M MacDonald, Catherine Cluver, Roxanne Hastie, Lina Bergman, Lesley McCowan, Rennae Taylor, Emerson Keenan, Natalie J Hannan, Ping Cannon, Tuong-Vi Nguyen, Manju Kandel, Stephen Tong

Gynecology II
Moderators:
Sarah Berga, MD
Dineo Khabele, MD

Salon KJ

O-069: Pregnancy Outcomes Following Routine Early Provision of IUD after First Trimester Induced Abortion - 5-year Follow-Up of a Randomized Controlled Trial
Oskari M Heikinheimo, Elina Pohjoranta, Satu Suhonen, Maarit Mentula, Mika Gissler

O-070: Towards 3-D Imaging of the Murine Vagina
Diego R Gatica, Li Guang, J Quincy Brown, Kristin S Miller

Withdrew 07.01.2021
O-071 :A Meta-Analysis Investigation of Anti-Mullerian Hormone Trends in Survivors of Childhood Cancer
Allison Kumnick, Veronica Gomez-Lobo, Ninet Sinaii, Jacqueline Maher

O-072: Euploid Miscarriage Is Associated with Lactobacillus spp. Deplete Vaginal Microbial Composition and Local Inflammation
Karen Grewal, Yun S Lee, Ann Smith, Jan J Brosens, Tom Bourne, Maya Al-Memar, Samit Kundu, David A MacIntyre, Phillip Bennett

O-073: Anemia and Abnormal Uterine Bleeding Prevalence in the Environment, Leiomyomas, Latina and Adiposity Study (ELLAS)
Torie C Plowden, Anne Waldo, Anita Malone, Felix M Valbuena, Charo Ledon, Donna D Baird, Erica E Marsh

O-074: Route of Myomectomy and Probability of Pregnancy or Live Birth
Sophia Anderson, Laine Thomas, Lauren Wise, Elizabeth A Stewart, COMPARE-UF Team

Parturition II
Moderators:
Carole Mendelson, PhD
Mala Mahendroo, PhD

Wellesley

O-075: Cell Free Fetal DNA (cffDNA) from Human Amnion Epithelial Cells Increase Inflammatory Load in Human Fetal Membrane Tissue
Chelsea Saito Reis, Samantha Oetjen, Claire Kendal-Wright

O-076: Microbial Metabolites Compromise Epithelial Barrier Integrity: Potential Mechanisms by Which Non-Optimal Cervicovaginal Microbiota Lead to Preterm Birth
Kristin D Gerson, Yusra Gimie, Lauren Anton, Michal A Elovitz

O-077: Single Cell Transcriptomics Identify Distinct Epithelial Populations in Early versus Late Pregnancy
Shanmugapriyaa Madhukaran, Anne Cooley, Gary Hon, Mala Mahendroo

O-078: Essential Roles of Uterine Peristalsis by Cav1.2 in Reproduction and Adenomyosis in Mice
Mingzi Qu, Ping Lu, Christina Baer, Lawrence Lifshitz, Ronghua ZhuGe

O-079: Differential Regulation of SOX Family Transcription Factors in the Pregnant and Labouring Mouse Myometrium
Nawrah Khader, Virlana Shchuka, Anna Dorogin, Oksana Shynlova, Jennifer Mitchell

O-080: Intrauterine Infection Induced Preterm Labor Is Associated with Site-Specific Phosphorylation of Progesterone Receptor A in Myometrial Cells
Rachel A Wilson, Pietro Presicce, Monica Cappelletti, Alan Jobe, Senad Divanovic, Sing Sing Way, Claire Chougnet, Sam Mesiano, Suhas Kallapur

Reproductive Endocrinology and Infertility I
Moderators:
Nanette Santoro, MD
Valerie Flores, MD

Suffolk

O-081: Cumulus Cells Transcriptomic Biomarkers of Euploid Human Embryo Implantation
Cynthia Scott, Shiny Titus, Emre Seli

O-082: Rapid Aneuploidy Testing in Reproduction Using Nanopore-Based Sequencing
Shan Wei,  Alexandre Djandji, Nataly Hoffman, Claudia Cujar, Refik Kayali, Cegniz Cinnioglu, Ronald Wapner, Mary D’Alton, Brynn Levy, Zev Williams

O-083: Characterization of the Non-Classic Progesterone Receptor Membrane Component 2 (PGRMC2) during the Human Menstrual Cycle and In Vitro Decidualization
Yassmin Medina-Laver, Indra Diaz-Hernandez, Pilar Alama, Roberto Gonzalez-Martin, Andrea Palomar, Alicia Quiñonero, Francisco Dominguez

O-084: Human Placenta Mesenchymal Stem Cells Derived Exosomes Successfully Reverse Infertility in Chemotherapy Induced Premature Ovarian Insufficiency Mouse Model
Esra Cetin, Hang-soo Park, Hiba Siblini, Ayman Al-Hendy

O-085: An In Vivo Model of Human FSH Dysregulation in Obesity: Obese Women Exhibit Lower Serum FSH Levels in Response to Intravenous Recombinant FSH after GnRH Suppression
Katherine Kuhn, Thanh-Ha Luu, Andrew P Bradford, Luke Wittenberg, Nne-Omoji Nwobodo, Polotsky J Alex, Michael Wempe, PhD

O-086: Different Immunoregulatory Components at the Decidua Basalis of Oocyte Donation Pregnancies
Kim van Bentem, Manon Bos, Carin van der Keur, Hanneke Kapsenberg, Lisa Lashley, Michael Eikmans, Marie-Louise van der Hoorn

3:30 p.m. - 4:00 p.m.

Coffee Break

Level 3 Foyer & Level 4 Grand Ballroom Foyer

4:00 p.m. - 5:30 p.m.

Poster Session I

Back Bay Conference and Exhibition Center

5:45 p.m. - 6:30 p.m.

President's Distinguished Researchers Award I

Salon E-F

Joan Steitz, PhD
Sterling Professor of Molecular Biophysics and Biochemistry
Yale School of Medicine

6:30 p.m. - 7:10 p.m.

Awards Ceremony

Salon E-F

• 2020 Recipients
  • The DeCherney Society Lifetime Distinguished Service Award: Sarah Berga
  • The SRI Distinguished Scientist Award: Hugh Taylor
  • The President's Achievement Award: Kjersti Aagaard
  • The SRI Mentorship Award: Sarah Robertson

• 2021 Recipients
  • DeCherney Society Lifetime Distinguished Service Award
  • SRI Mentorship Award
  • SRI Distinguished Scientist Award
  • SRI President’s Achievement Award

7:30 p.m. - 9:00 p.m.

Connection Corners

3rd Floor Atrium

Registration

7:00 a.m. - 8:00 a.m.

SRI Business Meeting
*Breakfast will be served and ALL SRI Members are invited to attend

Salon E-F

8:00 a.m. - 9:00 a.m.

President's Distinguished Researchers Award II

Salon E-F

Gregg L. Semenza, MD, PhD
C. Michael Armstrong Professor of Genetic Medicine
Johns Hopkins University School of Medicine

9:00 a.m. - 9:45 a.m.

Hot Topics & Awards Ceremony

Salon E-F

9:00 a.m. - 9:15 a.m.

O-153: Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response
Denise Chan, Phillip R Bennett, Yun S Lee, TG Teoh, Malko Adan, Saqa M Ahmed, Richard G Brown, Anna L David, Holly Lewis, Belen Gimeno-Molina, Jane E Norman, Sarah J Stock, Vasso Terzidou, Pascale Kropf, Marina Botto, David A MacIntyre, Lynne Sykes

9:15 a.m. - 9:30 a.m.

O-154: Complement Blockade with Eculizumab for Treatment of Pregnant or Postpartum Women with Severe Coronavirus Disease 2019
Richard M Burwick, Gabriela Dellapiana, Rachel Newman, Sarah Smithson, Mariam Naqvi, John Williams III, Melissa Wong, Martha Bautista, Anna Gaden, Shamsah Kazani, Mark Ma, Sanjay Mitter, Jon Monteleone, Stephan Ortiz, Mark Zakowski, Sara Ghandehari, Noah Merin, Ananth Karumanchi

9:30 a.m. - 9:45 a.m.

Awards Ceremony

• Giorgio Pardi Travel Awards
• Laxmi Baxi Awards
• Thomas McDonald Award
• Early Career Investigator Awards
• Chinese Program Travel Award
• The Kusum Lata Travel Award

9:45 a.m. - 10:15 a.m.

Coffee Break

10:15 a.m. - 11:45 a.m.

Concurrent Oral Presentations III

Epidemiology and Global Health
Moderators:
Shannon Whirledge. PhD, MSc
Shruthi Mahalingaiah, MD

Salon AB

O-087: Associations of Maternal Urinary Bisphenol and Phthalate Urine Concentrations in Pregnancy with Offspring Pubertal Development
Sophia Blaauwendraad, Romy Gaillard, Vincent Jaddoe

O-088: Maternal Levels of Perfluoroalkyl Substances (PFAS) during Early Pregnancy in Relation to Preeclampsia Subtypes and Biomarkers of Preeclampsia Risk
Paige A Bommarito, Kelly K Ferguson, John D Meeker, Thomas F McElrath, David E Cantonwine

O-089: Maternal Preconception Platelet Activation and Pregnancy Outcomes
Ashley Shea, Lauren Theilen, Heather Campbell, Erica Johnstone, Meredith Humphreys, Sunni Mumford, Alexandra Purdue-Smithe, Lindsey Sjaarda, Neil Perkins, Robert Silver, Enrique Schisterman

O-090: The Association between Living in a Food Desert and the Likelihood of Initiating Breastfeeding
Adriana Campos, Jean Paul Tanner, Ronee E Wilson, Jason L Salemi, Peeraya Sawangkum, Kimberly Fryer, Adetola Louis-Jacques

O-091: How Late Is Too Late to Reverse the Effects of the Developmental Origins of Health and Disease?
Craig E Pennell, Carol A Wang, Wendy H Oddy, Claire E Meyerkort, Stephen G Matthews

O-092: Predictors of Teenage Pregnancy in Zambia between 2007 and 2018
Claire H Packer,  Nelly-Claire Muntalima, Ana M Langer, Michael T Mbizvo

Developmental Programming II
Moderators:
Paul Rozance, MD
Laura Goetzl, MD

Salon CD

O-093: Maternal Exposure to Δ9-Tetrahydrocannabinol Results in Symmetrical IUGR Associated with Cardiac Dysfunction in Postnatal Life
Kendrick Lee, Kristian McCarthy, Steven R Laviolette, Qingping Feng, Daniel B Hardy

O-094: Under-Expression of Placental Endocrine-Specific Igf2 Programmes Cardiovascular Disease in the Adult Male Offspring
W Ching, Y Niu, T A Garrud, H Yong, E R Christoforou, J Lopez-Tello, D A Giussani, A N Sferruzzi-Perri

O-095: Accumulation of Suboptimal Periconceptional Social, Lifestyle and Medical Exposures as Markers for the Maternal Vulnerable Condition and Impairment of Embryonic Growth: The Rotterdam Periconceptional Cohort (Predict Study)
Sofie KM van Zundert, Lenie van Rossem, Sten P Willemsen, Lindsey van der Meer, Hiske E Ernst-Smelt, Régine PM Steegers-Theunissen

O-096: Maladaptive Cardiomyocyte Calcium Handling in Adult Offspring of Hypoxic Pregnancy: Protection by Antenatal Maternal Melatonin
Mitchell C Lock, Kerri LM Smith, Youguo Niu, Olga V Patey, Sage G Ford, Andrew W Trafford, Dino A Giussani, Gina LJ Galli

O-097: Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal and Infantile Pulmonary Hypertension in High-Altitude Populations
Alexandra Heath,  Colleen G Julian, Lilian Toledo-Jaldin, Inge von Alvensleben, Litzi Lazo Vega, Hussna Yasini, Jesus Dorado Madera, Margaret Stalker, Julie A Houck, Lorna G Moore

O-098: Reduced TGFβ Responsiveness in Skeletal Muscle Satellite Cells from Lambs with Fetal Growth Restriction
Rosa I Luna Ramirez, Miranda J Anderson, Ravi Goyal, Sean W Limesand

Reproductive Biology II
Moderators:
Warren Nothnick, PhD
Robert Taylor, MD, PhD

Salon HI

O-099: Polycomb Repressive Complex 2 Antagonizes Wound Healing Responses in the Decidual Stroma by Modulating the Transforming Growth Factor Beta Pathway
Ivan Osokine, Damon Rideaux, Tara McIntyre, Johan Siewiera, Adrian Erlebacher

O-100: Proteomic Analysis of Extracellular Vesicles Secreted by Primary Endometrial Epithelial Cells from Fertile Women Reveals Functions Related to Embryo Implantation Not Present in an Endometrial Epithelial Cell Line
Marina Segura-Benítez, María Cristina Carbajo-García, Ana Corachán, Amparo Faus, Antonio Pellicer, Hortensia Ferrero

O-101: Jagged1 Regulates Endometrial Receptivity in Both Humans and Mice
Wei Zhou, Ellen Menkhorst, Evdokia Dimitriadis

O-102: Antiphospholipid Antibodies Accelerate Endometrial Stromal Cell Decidualization and Senescence and Induce Inflammation via TLR4, p38 MAPK and ROS Signaling
Mancy Tong, Teimur Kayani, Deidre M Jones, Lawrence W Chamley, Vikki M Abrahams

O-103: The Long-Term Impact of Selective Progesterone Receptor Modulator (SPRM) Ulipristal Acetate (UPA) on the Cell Cycle and Cell Proliferation in Human Endometrium as Assessed by RNA Sequencing
Aleksandra Tsolova, Rohan Chodankar, Alison Murray, Lucy Whitaker, Moira Nicol, Alistair Williams, Hilary Critchley

O-104: Next Generation of Human Endometrial Organoids: Bioengineering-Based Strategies for Preserving Tissue-Specific Extracellular Environment
Emilio Francés-Herrero, Elena Juárez-Barber, Hannes Campo, Sara López-Martínez, Lucía de Miguel-Gómez, Amparo Faus, Antonio Pellicer, Hortensia Ferrero, Irene Cervelló

Placenta II
Moderators:
Elizabeth Ann Enninga, PhD
Yoel Sadovsky, MD

Salon KJ

O-105: Fibronectin-Integrin Interactions Regulate Placental Endothelial Cell Migration in Severe Fetal Growth Restriction
Diane L Gumina, Shuhan Ji, Kathryn McPeak, Emily J Su

O-106: Characterization of Regulation of NLRP3 Inflammasome Activity in Placental Hofbauer Cells
Magnolia G Wang, Seth Guller

O-107: AKT Signaling Controls Trophoblast Development and Placentation
Keisuke Kozai, Mae-Lan Winchester, Mikaela E Simon, Khursheed Iqbal, Masanaga Muto, Regan L Scott, Chad Slawson, Michael J Soares

O-108: Changes in Lipid Profiles of Placental Exosomes in Maternal Plasma Characterize Pregnancies with a Small-for-Gestational Age Fetus
Miira M Klemetti, Ante BV Pettersson, Porter R Tyler, Aafaque Khan, Premy Shan, Hannes Röst, Martin Post, Isabella Caniggia

O-109: Velocity-Selective Arterial Spin Labeling Perfusion Measurements in 2^nd Trimester Human Placenta
Daniel Seiter, Ruiming Chen, Kai Ludwig, Ante Zhu, Dinesh Shah, Sean Fain, Oliver Wieben, Kevin M Johnson

O-110: Placental NRF2 May Serve a Key Role in Maternal-Fetal Tolerance during Pregnancy
Kyunghee Hong, Youn-Tae Kwak, Sribalasubashini Muralimanoharan, Carole R Mendelson

Reproductive Endocrinology and Infertility II
Moderators:
Emre Seli, MD
Mindy Christianson, MD

Wellesley

O-111: Premenstrual Dysphoric Disorder (PMDD) Is Associated with Estradiol-Dependent Aberrations in Cellular Ca2+ Homeostasis and the Endoplasmic Reticulum Stress Response
Howard Li, Neelima Dubey, Jessica F Hoffman, David R Rubinow, Peter J Schmidt, David Goldman

O-112: Examination of Androgen Effects on Female Reproductive Axis: Hypothalamus-Pituitary-Ovary
Sheng Wu, Olubusayo Awe, Mingxiao Feng, James Segars

O-113: Disparities in Seeking Infertility Care: Data from the 2017-2019 CDC National Survey of Family Growth
Lauren E Barrison, Allison R Kumnick, Veronica Gomez-Lobo, Jaqueline Y Maher

O-114: Normal Weight Women with Polycystic Ovary Syndrome (PCOS) Exhibit Oxidative Stress in Response to Saturated Fat Ingestion Even in the Absence of Abdominal Adiposity (AA)
Frank González, Robert V Considine, Ola A Abdelhadi, Jiaping Xue, Anthony J Acton

O-158: Dysregulation of Primordial Follicle Growth Activation Regulatory Factor Expression in a Granulosa Cell Model of Galactosemic Primary Ovarian Insufficiency
John Rushing, Evelyn Llerena Cari, Synneva Hagen-Lillevik, Amanda Kallen,
Alex J. Polotsky, Joshua Johnson
 

Clinical and Translational Perinatology II
Moderators:
Amy Murtha, MD
Anna Powell, MD

Suffolk

O-115: Preferred Timing of Efficacy of a New Therapeutic Candidate, Rytvela, for Prevention of Inflammation-Induced Preterm Birth and Fetal Growth Restriction
Sarah-Eve Loiselle, Renay Poupart, Xin Hou, Mathieu Nadeau-Vallée, France Côté, Tiffany Habelrih, Christiane Quiniou, Sylvain Chemtob

O-116: Comparative Adverse Effects of Antenatal Glucocorticoid Formulations: Studies in the Chicken Embryo
T A Garrud, N Teulings, F G Conlon, W Tong, S G Ford, Y Niu, L M Nicholas, J B Derks, S E Ozanne, D A Giussani

O-117: Maternal Leukocyte DNA Methylation during Asymptomatic Pregnancy and Future Spontaneous Preterm Birth among Black American Women
Shannon Gillespie, Chenggong Han, Zilu Liu, Cindy Anderson, Shili Lin

O-118: Impact of Progesterone on Mechanism of Preterm Premature Rupture of Membrane
Heejoong Lee, Banghyun Lee

O-119: A Novel Murine Model of Cytomegalovirus Infection in Pregnancy
Angela Shaddeau, Gregory Kirschen, Anna Chudnovets, Quan Na, Ayan Ghosh, Halli Miller, Jun Lei, Ravit Boger, Andrew Thagard, Karen Racicot, Irina Burd

O-120: Psychological Distress during Pregnancy and Adverse Maternal and Perinatal Health Outcomes; the Role of Socioeconomic Status
Leonie A Daalderop, Jacqueline Lagendijk, Eric AP Steegers, Hanan El Marroun, Anke G Posthumus

12:00 p.m. - 1:00 p.m. 

Diversity, Equity and Inclusion Forum
*Boxed lunches will be provided at no cost for this session. The capacity for this session is 100 attendees and registration for this session will close once full or on the Registration Deadline.

Salon AB

Moderator: 
Ayman Al-Hendy, MD, PhD

How to Create an Environment Supportive of Diversity, Equity and Inclusion
Genevieve S. Neal-Perry, MD, PhD, Chief, Reproductive Endocrinology and Infertility
University of Washington, Seattle, WA, USA

12:00 p.m. - 1:00 p.m.

Lunch and Learn Symposium III 
*Boxed lunches are available and complimentary through the Registration Deadline only.

Don't Get Lost in Translation: Importance of In Vivo and In Vitro Model Validation
Supported by Bayer
Moderators: 
Erica Marsh, MD, MSCI, FACOG

Salon CD

Back-Translation of Clinical Endpoints and Model Validation in Preclinical Research (fibroids examples)
Thomas M. Zollner, MD

12:25 p.m. - 12:50 p.m.

Modeling Artificial Ovary 
Monica M. Laronda, PhD

12:50 p.m. - 1:00 p.m.

Session Q&A

Lunch and Learn Symposium IV
*Boxed lunches are available and complimentary through the Registration Deadline only.

Beyond Surgery: Managing Uterine Fibroids in 2021..and Beyond

Supported by Myovant Science / Pfizer
Moderators: 
Shannon Whirledge, PhD, MHS
Bill Catherino, MD, PhD

Salon HI

12:00 p.m. - 12:15 p.m

Non-Surgical Interventions for Uterine Fibroids
Elizabeth A. Stewart, MD

12:15 p.m. - 12:30 p.m.

Non-Hormonal Options for Uterine Fibroids
Mostafa Borahay, MBBCh, MSc, PhD

12:30 p.m. - 12:45 p.m

Hormonal Options for Uterine Fibroids
Ayman Al-Hendy, MD, PhD

12:45 p.m. - 1:00 p.m.

Session Q&A

1:15 p.m. - 2:45 p.m.

Concurrent Oral Presentations IV

Fetus II
Moderators:
Neeta Vora, MD
Aleksandar Stanic-Kostic, MD, PhD

Salon AB

O-121: MAP4K4: Identification of a Novel Candidate Gene Using Prenatal Exome Sequencing Data and Functional Modeling in Zebrafish
Neeta L Vora, John Griffin, Kelly Gilmore, Julie K Holsclaw, Elizabeth Bhoj, Erica E Davis

O-122: An Aberrant Endothelial Cell Response to Flow: Mechanistic Implications for Congenital Heart Defects in the Feto-Placental Unit
Yalda Afshar, Anhyo Jeong, Christine Jang, Gary Satou, Mark Sklansky, M Luisa Iruela-Arispe

O-123: Measuring In Vivo Arterial Stiffness in Fetal Life
Nima Moghaddas, Beth J Allison, Youguo Niu, Kimberley J Botting, Carmel M McEniery, Dino A Giussani

O-124: In Utero e-Cigarettes Exposure Enhances Neonatal Brain Ischemic Damage: Role of the miRNA-30c
Andrew Walayat, Yanyan Zhang, Yong Li, Asanjan Hosseini Maryam, Daliao Xiao

O-125: Early and Mid-Gestation Zika Virus (Zikv) Infection in the Olive Baboon (Papio anubis) Leads to Neurological Birth Defects Due to Congenital Zika Syndrome (czs)
Sunam G Dockins, Darlene N Reuter, Marta E Maxted, Ashley A Martin, Molly E Dubois, James F Papin, Dean A Myers

O-126: Thyroid Hormone Dominates IGF1 Expression and Actions in Fetal Cardiomyocytes
Natasha N Chattergoon, Samantha Louey, Sonnet Jonker, George Giraud, Kent L Thornburg

Health Disparities and COVID
Moderators:
Ayman Al-Hendy, MD, PhD
Michal Elovitz, MD

Salon CD

O-127: Black and White Women in the United States Military Have Comparable Rates of Preeclampsia and Post-Preeclamptic Cardiovascular Disease
Andrea I Loewendorf, Emily A Stone, Lee Ann Zarzabal, Thornton Mu, Amelia Duran-Stanton

O-128: Racial and Ethnic Disparities in Complications among Patients Undergoing a Trial of Labor after Cesarean Section at Mount Sinai Hospital
Ayisha Brielle Buckley, Stephanie Sestito, Tonia Ogundipe, Natalie Cohen, Mitchell Rosenberg, Kelly Wang, Jill Berkin, Stoffels Guillaume, Chelsea DeBolt, Jessica Peterson, Joanne Stone, Angela Bianco, Luciana Vieira

O-129: Potential Risk of Infection of First Trimester Placentas by SARS-CoV2
Sampada Kallol, Laura Martin-Sancho, Donald Pizzo, Sumit K Chanda, Mana Parast, Francesca Soncin

O-130: Impact of SARS-CoV-2 Infection during Pregnancy by Maternal Race-Ethnicity
Darios Getahun, Lawrence D Lurvey, David Braun, David A Sacks, Jiaxiao Shi, Vicki Y Chiu, Morgan R Peltier, Michael J Fassett

O-131: Stressors in Fertility Treatment: The Impact of the COVID-19 Pandemic
Sarah Dynia, Caroline Peschansky, Safina Usmani, Sonia Patel, Kayla Vitale, Jawaria Amir, Royi Lynn, Lauren Grimm, Erica Louden, Roohi Jeelani, Angie Beltsos

O-132: Expression of SARS-CoV-2 Entry Molecules at Maternal-Fetal Interface and Regulation of Proinflammatory Cytokines and Coagulation Factor III in Human Placental Microvascular Endothelial Cell by Spike Protein
Xiaofang Guo, Umit A Kayisli, Asli Ozmen, Nihan Semerci, Kellie Larsen, Zhi Tian, Frederick Schatz, Diane Allen-Gipson, Ozlem Guzeloglu-Kayisli, Charles J Lockwood

Placenta III
Moderators:
Dinesh Shah, MD
Lipeng Feng, MD

Salon HI

O-133: Chorionic Somatomammotropin RNA Interference Reduces Global Nutrient Uptake and Umbilical Blood Flow Resulting in Intrauterine Growth Restriction
Amelia R Tanner, Cameron S Lynch, Victoria C Kennedy, Asghar Ali, Quinton A Winger, Paul J Rozance, Russell V Anthony

O-134: Trophoblast-Specific Knockdown of the System A Amino Acid Transporter, Slc38a2/SNAT2, Causes Fetal Growth Restriction in Mice
Owen R Vaughan, Elena Silva, Kenneth Barentsen, Russell V Anthony, Thomas L Brown, Theresa L Powell, Thomas Jansson

O-135: An In Vitro Placenta Model with a Native Stroma for Mechanistic Transport Studies
Katherine M Nelson, Sarah A Geissler, Jason P Gleghorn

O-136: Obesity Downregulates Lipid Metabolism Genes in First Trimester Placenta
Aisha Rasool, Begum Aydogan Mathyk, Danielle Roncari, Perrie O'Tierney-Ginn

O-159: A Multiomics Approach To Placental Dysfunction In Common
Obstetrical Syndromes
Oren Barak, Samantha Piekos, Tianjiao Chu, Elena Sadovsky, Jean-Francois
Moulliet, Yingshi Ouyang, Lee Hood, Nathan Price, Yoel Sadovsky

O-160: Determining the Impact of Environmental Toxin Cadmium at the Feto-
Maternal Interface Using an Organ-On-Chip (FMi-OOC) Device
Sungjin Kim, Lauren Richardson, Enkhtuya Radnaa, Zunwei Chen, Ivan Rusyn,
Ramkumar Menon, Arum Han

Reproductive Biology III
Moderators:
Elizabeth Bonney, MD
Monica Mainigi, MD

O-137: Thymic Progesterone Receptor Expression Regulates Maternal Thymic Involution in Murine Pregnancy
Soo Hyun Ahn, Sean L Nguyen, Tae-Hoon Kim, Jae-Wook Jeong, Ripla Arora, Margaret G Petroff

O-138: A Role for the IL-33-ILC2 Axis in Driving Uterus-Intrinsic Parturition Pathways in Mice
Johan Siewiera, Madelene Dahlgren, Kelly Cautivo, Damon Rideaux, Ari Molofsky, Adrian Erlebacher

O-139: Single-Cell RNA Sequencing Identifies Novel Uterine Macrophage Population Increased by Regulatory T Cells and Associated with Decreased Fetal Loss
Emma L Lewis, Paige M Porrett, Michal A Elovitz

O-140: Pluripotent Stem Cell Derived Endometrial Stromal Fibroblasts Co-Culture with Endometrial Epithelial Organoids to Form a 3-Dimensional Model of the Human Endometrium
Virginia Chu Cheung, Chian-yu Peng, Mirna Marinic, Noboru J Sakabe, Ivy Aneas, Vincent J Lynch, Carole Ober, Marcelo A Nobrega, John A Kessler

O-141: The Vertical Transfer of Maternal Immune Cells during Pregnancy Promotes Neonatal Immunity against Viral Infections in Mice
Ina Stelzer, Christopher Urbschat, Kristin Thiele, Ioanna Triviai, Julian Kottlau, Felix Stahl, Maria Emilia Solano, Petra Arck

O-142: Differentiation of Mouse iPSCs into Functional Oocytes
Raymond M Anchan, Nicholas W Ng, Kha U Dam, Ankrish Milne, Emily R Disler, Nicole Dunn, Kevin M Elias, Elizabeth Ginsburg

Preeclampsia II
Moderators:
Kathryn Gray, MD, PhD
Leslie Myatt, PhD, FRCOG

Wellesley

O-143: HO-1 Genetic Variants Display Racial Diversity and May Impact Hypertensive Disorders in Pregnancy
Tianyanxin Sun, Nima Mousavi, Ronald J Wong, Nazish Sayed, Joseph C Wu, David K Stevenson, Melissa Gymrek, Virginia D Winn

O-144: Surgically Increasing Uteroplacental Impedance Results in Attenuated Uterine Vascular Remodeling and Preeclampsia-Related Placental Secretomics during Pregnancy
Nga Ling Ko, Narmin Mukhtarova, Catrina Hood, Ying Wai Lam, George Osol

O-145: The New Generation Antiplatelet Agent Prasugrel Represents an Exciting Novel Candidate Therapy for Preeclampsia
Natalie Hannan, Natasha De Alwis, Natalie Binder, Sally Beard, Vi Nguyen, Kaitu'u-Lino Tu'uhevaha, Stephen Tong

O-146: Sildenafil Improves Placental Function and Remodeling in Preeclamptic Rats
Dylan J Lawrence, Carolyn L Bayer

O-147: Differential Distribution of Tryptophan-Metabolites in Fetal and Maternal Circulations during Pregnancy: Preeclampsia-Elevated Aryl Hydrocarbon Receptor Ligands
Ying-jie Zhao, Chi Zhou, Ying-ying Wei, Hui-hui Li, Kai Wang,  Jing Zheng

O-148: Can WS1442 Ameliorate Maternal Vascular Dysfunction in Preeclampsia?
Stephanie A Worton, Yasmin Mills, Susan L Greenwood, Jenny E Myers

Gynecology Oncology
Moderators:
Jessica Hebert, PhD
Dineo Khabele, MD

Suffolk

O-149: Evaluation of ATR Inhibitors for Targeted Therapy of Ovarian Clear Cell Carcinoma
Jing Ji, Zhigui Li, Emily Sherman, Oloruntoba Osagie, Shijun Mi, Whitney Soble, Jessie LI, Gloria Huang

O-150: Endoplasmic Reticulum Stress Response to Hyperinsulinemia in Endometrial Epithelial Cells Depends on PIK3CA Mutation
Mike R Wilson, Ronald L Chandler

O-151: ACS NSQIP - Personalised Risk Prediction Tool for Postoperative Complications in Gynaeoncology Surgery?
Lusine Sevinyan, Sadie Jones, Jonathan Horne, Rasiah Bharathan, Anil Tailor, Simon Butler-Manuel, Peter Williams, Thumuluru Kavitha Madhuri

O-152: High NLRP7 Expression Promotes Choriocarcinoma Development: Proof
of Concept from Clinical and Preclinical Studies
Deborah Reynaud, Roland Abi Nahed, Nicolas Lemaitre, Pierre-Adrien
Bolze, Touria Aboussaouira, Padma Murthi, Rima Slim, Mohamed
Benharouga, Nadia Alfaidy

O-161: Entinostat Increases Sensitivity to Olaparib in a Homologous
Recombination Proficient Syngeneic Mouse Model of Ovarian Cancer
Vijayalaxmi G Gupta, Yosklay L Fernandez, Katherine F Roby, Fiona Yull, Marta
A Crispens, Andrew J Wilson, Harsh B Pathak, Andrew K Godwin, Andrea
Jewell, Dineo Khabele

O-162: Factors Associated with Referral-Based Receipt of Fertility
Consultation Among Reproductive Age Women with Pre-invasive or Invasive
Gynecologic Malignancies
Ruoxi Yu, Anna L Beavis, Mindy S Christianson, Kala Visvanathan, Akila N
Viswanathan, Rebecca L Stone

2:45 p.m. - 4:15 p.m. 

Poster Session II

Back Bay Conference and Exhibition Center

4:15 p.m. - 6:15 p.m.

Mini Symposia II

SRI – SSR Joint Session: Immune Cell Regulation of Implantation/Pregnancy
Moderator: 
Bo Rueda, PhD
Soo Hyun Ahn, PhD

Salon AB

Neutrophils at the Maternal-Fetal Interface: Friend or Foe?
Vicki M. Abrahams, PhD

The Stage Is Set Before the Play Commences – Maternal Immunological Detection of the Conceptus
Troy Ott, PhD

Maternal Immunity and Tolerance During Pregnancy
Margaret G. Petroff, PhD

Fetal-Maternal Disagreement: Immune Responses in Placental Villitis
Elizabeth Ann Enninga, PhD

Session Q&A

Update on Diagnostics and Therapeutics for Preterm Birth
Moderators: 
David M. Olson, PhD
Kelycia B. Leimert, PhD

Suffolk

Overview of the Pathway to Preterm Birth
Kelycia B. Leimert, PhD

Leukocyte Migration as a Diagnostic for Delivery
David M. Olson, PhD

New and Emerging Biomarker Prediction Tests for Preterm Birth
Laura Jelliffe-Pawlowski, PhD

Development of Novel Therapeutics to Counter Preterm Birth
Sylvain Chemtob, MD, PhD

Pharmaceutical industry development in preterm labor treatment: current landscape
Elizabeth (Beth) Garner, CMO

Session Q&A

Drivers and Therapeutic Targets for Gynecologic Cancers Associated with Benign Gynecologic Conditions
Moderators: 
Dineo Khabele, MD, FACOG, FACS
Gloria Huang, MD

Salon CD

ARID1A as a Driver and Target for Therapy for Endometriosis-Associated Ovarian Cancer (Implications for Immunotherapy)
Rugang Zhang, PhD

Toxicant Exposure, Endocrine Disruptors and Adenomyosis (Environmental Influence)
Kaylon L. Bruner-Tran, PhD

The Insulin/Insulin Growth Factor and Sex Hormone Axes in the Normal Endometrium and in Tumor Microenvironment of Endometrial Cancer (Environmental Influence of Obesity and Implications for Immunotherapy)
Gloria Huang, MD

Mouse Models of Endometriosis-Associated Gynecologic Cancers
Warren B. Nothnick, PhD

Session Q&A

Antenatal Steroid Therapy Optimisation. From Clinic to Bench and Back Again
Moderator: 
Matthew W. Kemp, PhD

Wellesley

When, What and How Often? Revisiting the Scientific Basis of Antenatal Steroid Therapy
Citra N. Mattar, PhD, MBBS, Mmed, MRANZCOG

Hunting for Goldilocks - Efforts Past and Present to get Antenatal Steroid Dosing Just Right
Matthew W. Kemp, PhD

Optimisation of Antenatal Steroids for Low and Middle Income Countries
Alan H Jobe, MD, PhD

Short & Long Term Benefits & Risks of Multiple Courses of Antenatal Corticosteroids
Kellie E. Murphy MD, MSc

Session Q&A

Role of miRNA’s and Inflammation in the Pathology of Endometriosis
Moderator:
Valerie A. Flores, MD
Niraj R. Joshi, PhD

Salon KJ

Insights Into Contributions of Stem Cell and Inflammatory Pathways in the Pathophysiology of Endometriosis
Caroline E. Gargett, PhD

Macrophages in the Pathophysiology of Endometriosis: Mouse Models As Tools for Clinical Translation
Erin Greaves, PhD

miRNA’s in Endometriosis: Pathological Insights and Clinical Implications From a Baboon Model
Niraj R. Joshi, PhD

miRNA’s in Endometriosis: Diagnostic Potential and Pathophysiology in Women With Disease
Hugh S. Taylor, MD

Session Q&A

An Update on the Impact of COVID-19 on Maternal-Child Health,
Supported by March of Dimes
Moderators: 
Rahul Gupta, MD, MPH, MBA, FACP
David M. Aronoff, MD

HIGHLY PATHOGENIC RESPIRATORY VIRUS INFECTIONS IN PREGNANCY:
Lessons Learned from COVID-19 and How To Prepare For The Next Pandemic
Kristina Adams Waldorf, MD

Risks to the fetus of maternal COVID-19, an evidence-based analysis
Andrea Edlow, MD

Placental changes in response to infection and vaccination
Jeff Goldstein, MD, PhD
Elisheva Shanes, MD

What COVID-19 may mean to the developmental origins of health and disease
Rebecca Simmons, MD

Session Q&A

9:00 a.m. - 1:00 p.m.

Career Development Workshops                                                                                        

Virtual                     

1:30 p.m. - 2:30 p.m.

Your Grant in One Page Clinic

Virtual