Detailed Agenda
Please note - Information listed in the Detailed Agenda is subject to changes and continually being updated to reflect the most up to date information.
9:00 a.m. - 12:00 p.m. |
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11:00 a.m. - 6:00 p.m. |
Registration |
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1:00 p.m. - 5:45 p.m. |
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6:00 p.m. - 7:30 p.m. |
Mentor in a Cloud Networking Event |
7:30 a.m. - 6:30 p.m. |
Registration |
LOBBY - VCC EAST LEVEL 1 |
8:30 a.m. - 12:00 p.m. |
VARIOUS ROOMS |
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12:00 p.m. - 1:00 p.m. |
Mid-Career Session |
EAST MEETING ROOM 11 & 12 - VCC EAST LEVEL 2 |
1:30 p.m. - 5:00 p.m. |
VARIOUS ROOMS |
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5:15 p.m. - 6:15 p.m. |
EAST MEETING ROOM 11 & 12 - VCC EAST LEVEL 2 |
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6:30 p.m. - 8:00 p.m. |
Welcome Reception |
EAST BALLROOM AB -VCC EAST LEVEL 1 |
7:00 a.m. - 6:00 p.m. |
Registration |
LOBBY - VCC EAST LEVEL 1 | |
8:00 a.m. - 9:00 a.m. |
8:00 a.m. - 8:10 a.m. |
President's Welcome |
EAST BALLROOM ABC -VCC EAST LEVEL 1 |
8:10 a.m. - 9:00 a.m. |
March of Dimes Developmental Biology Prize Presentation and Lecture and Agnes Higgins Award Announcement The March of Dimes and Richard B. Johnston, Jr., MD Prize in Developmental Biology honors an outstanding scientist who has profoundly advanced the science that underlies our understanding of pregnancy, parturition and prenatal development. The Prize is sponsored by the Society for Reproductive Investigation, whose mission to advance reproductive and women’s health care through outstanding basic, translational and clinical science and by training and mentoring future generations of investigators complements March of Dimes’ work to support healthy moms and strong babies. The recipients of the Prize are leaders in reproductive biology working on translational and actionable science that can develop into interventions or preventions that will improve the health of moms and babies everywhere. |
EAST BALLROOM ABC -VCC EAST LEVEL 1 |
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9:00 a.m. - 10:00 a.m. |
President's New Investigator Plenary - |
EAST BALLROOM ABC -VCC EAST LEVEL 1 |
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Moderators: |
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9:00 a.m - 9:15 a.m. |
O-001: Premenstrual Dysphoric Disorder (PMDD) is Associated with Estradiol-dependent Aberrations in Cellular Ca2+ Homeostasis and the Endoplasmic Reticulum Stress Response |
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9:15 a.m. - 9:30 a.m. |
O-002: Fetal Heart Rate Decelerations in Women with Sleep-Disordered Breathing |
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9:30 a.m. - 9:45 a.m. |
O-003: Acute Treatment with Granulocyte-Colony Stimulating Factor at Advanced Reproductive Age Improves Ovarian Reserve |
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9:45 a.m. - 10:00 a.m. |
O-004: Placental Central Carbon Metabolism Links Polyamines to Histone Acetylation |
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10:00 a.m. - 10:30 a.m. |
SRI President's Presenters Awards Presentation |
EAST BALLROOM ABC -VCC EAST LEVEL 1 |
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10:30 a.m. - 12:00 p.m. |
Poster Session I |
EAST EXHIBIT HALL B - VCC EAST LEVEL 1 |
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12:00 p.m. - 1:30 p.m. |
Lunch and Learn Symposium I |
EAST MEETING ROOM 1 - VCC EAST LEVEL 2
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Big Data and the Impact on Scientific Success |
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12:00 p.m. - 12:30 p.m. |
Introduction to Big Data Analysis |
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12:30 p.m. - 1:00 p.m. |
Multi-Omics Approach in Uterine Fibroids Research |
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1:00 p.m. - 1:30 p.m. |
Systems Biology Study to Puzzle out Preterm Birth with an Integrated-Omics Approach |
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12:00 p.m. - 1:30 p.m. |
Lunch and Learn Symposium II |
EAST MEETING ROOM 11&12 - VCC EAST LEVEL 2 |
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NIH and Reproductive Medicine |
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12:00 p.m. - 12:25 p.m. |
NICHD Strategic Planning Update |
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12:25 p.m. - 12:50 p.m. |
Strategies for Obtaining NIH Extramural Funding |
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12:50 p.m. - 1:15 p.m. |
Life as an Intramural NIH Researcher |
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1:15 p.m. - 1:30 p.m. |
Introduction of NIH/NICHD Staff |
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1:35 p.m. - 3:35 p.m. |
Concurrent Mini-Symposia I |
VARIOUS ROOMS |
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Antenatal Steroid Therapy Optimisation. From Clinic to Bench and Back Again |
EAST MEETING ROOM 13 - VCC EAST LEVEL 2 |
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1:35 p.m. - 2:05 p.m. |
When, What and How Often? Revisiting the Scientific Basis of Antenatal Steroid Therapy |
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2:05 p.m. - 2:35 p.m. |
Hunting for Goldilocks - Efforts Past and Present to get Antenatal Steroid Dosing Just Right |
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2:35 p.m. - 3:05 p.m. |
Optimisation of Antenatal Steroids for Low and Middle Income Countries |
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3:05 p.m. - 3:35 p.m. |
Short & Long Term Benefits & Risks of Multiple Courses of Antenatal Corticosteroids |
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Pregnancy – A Lost Opportunity to Screen |
EAST MEETING ROOM 11 & 12 - VCC EAST LEVEL 2 |
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1:35 p.m. - 2:05 p.m. |
Placental Insufficiency and Impact on Fetal Development |
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2:05 p.m. - 2:35 p.m. |
Screening for Subclinical Cardiovascular Disease Following Pre-Eclampsia |
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2:35 p.m. - 3:05 p.m. |
Pregnancy Complications and the Life Course – Implications for the Child |
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3:05 p.m. - 3:35 p.m. |
Patient-Reported Outcomes and the Feasibility of Tracking Long-Term Cardiovascular Disease Outcomes – The Preeclampsia Foundation Registry |
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Role of miRNA’s and Inflammation in the Pathology of Endometriosis |
EAST MEETING ROOM 2 - VCC EAST LEVEL 2 |
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1:35 p.m. - 2:05 p.m. |
Insights into Contributions of Stem Cell and Inflammatory Pathways in the Pathophysiology of Endometriosis |
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2:05 p.m. - 2:35 p.m. |
Macrophages in the Pathophysiology of Endometriosis: Mouse Models As Tools for Clinical Translation |
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2:35 p.m. - 3:05 p.m. |
miRNA’s in Endometriosis: Pathological Insights and Clinical Implications from a Baboon Model |
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3:05 p.m. - 3:35 p.m. |
miRNA’s in Endometriosis: Diagnostic Potential and Pathophysiology in Women with Disease |
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Reproductive Infectious Diseases: From Bench to Bedside to Tomorrow |
EAST MEETING ROOM 3 - VCC EAST LEVEL 2 |
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1:35 p.m. - 2:05 p.m. |
Understanding the Management of Hepatitis B and C in Pregnant or Reproductive Age Women |
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2:05 p.m. - 2:35 p.m. |
Mechanisms of Group B Streptococcus as a Cause of Chorioamnionitis, Preterm Birth & Stillbirth |
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2:35 p.m. - 3:05 p.m. |
Placental Malaria: The Inflammatory Response and Fetal Growth Restriction |
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3:05 p.m. - 3:35 p.m. |
STIs, the Vaginal Microbiome, and Reproductive Health: Recent Evidence and Clinical Applications |
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Embryo Aneuploidy and Mosaicism: Implications for Reproduction and ART |
EAST MEETING ROOM 8 & 15 - VCC EAST LEVEL 2 |
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1:35 p.m. - 2:05 p.m. |
Understanding Aneuploidy |
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2:05 p.m. - 2:35 p.m. |
Developmental Potential of Aneuploid Human Embryos Beyond Implantation |
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2:35 p.m. - 3:05 p.m. |
Assessment of Aneuploidy and Mosacisim in Human Embryos: Promises and Pitfalls of Molecular Approaches and Study Designs |
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3:05 p.m. - 3:35 p.m. |
New Insights from Clinical NIPT Data Regarding Human Aneuploidy and Mosaicism |
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Update on Diagnostics and Therapeutics for Preterm Birth |
EAST BALLROOM ABC - VCC EAST LEVEL 1 |
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1:35 p.m. - 2:05 p.m. |
The Need for, Barriers to, and Hope for New Preterm Birth Diagnostics and Therapeutics |
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2:05 p.m. - 2:35 p.m. |
New and Emerging Biomarker Prediction Tests for Preterm Birth |
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2:35 p.m. - 3:05 p.m. |
Development of Novel Therapeutics to Counter Preterm Birth |
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3:05 p.m. - 3:35 p.m. |
Challenges in Developing New Treatment Options for Preterm Birth – From Industry’s Perspective |
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3:35 p.m. - 4:00 p.m. |
Coffee Break |
FOYER SOUTH |
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4:00 p.m. - 6:00 p.m. |
Concurrent Oral Presentations I |
VARIOUS ROOMS |
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Clinical and Translational Perinatology I |
EAST MEETING ROOM 2 – VCC EAST LEVEL 2 |
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4:00 p.m. - 4:15 p.m. |
O-005: Maternal Urinary Metabolites in the Latter Half of Pregnancy Predict Gestational Diabetes Mellitus |
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4:15 p.m. - 4:30 p.m. |
O-006: Advanced Paternal Age Is Associated With an Increased Risk of Spontaneous Miscarriage: A Systematic Review and Meta-Analysis |
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4:30 p.m. - 4:45 p.m. |
O-007: Placental MiRNAs Predicted to Target Insulin Signaling Pathways are Associated with Maternal Insulin Resistance in Late Pregnancy |
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4:45 p.m. - 5:00 p.m. |
O-008: Postpartum Transient Elastography in Patients with Metabolic Disorders of Pregnancy |
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5:00 p.m. - 5:15 p.m. |
O-009: Adipose Tissue Extracellular Vesicles from Women with Gestational Diabetes Exhibit Tissue-specific Suppression of Insulin Signaling |
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5:15 p.m. - 5:30 p.m. |
O-010: A Novel Murine Model of Cytomegalovirus Infection in Pregnancy |
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5:30 p.m. - 5:45 p.m. |
O-011: Anti-LPS Antibodies and Stillbirths |
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5:45 p.m. - 6:00 p.m. |
O-012: Regulatory T Cell Adoptive Transfer Alters Macrophage Populations at the Maternal-Fetal Interface and Decreases Late Fetal Loss |
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Gynecology I |
EAST BALLROOM ABC – VCC EAST LEVEL 1 |
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4:00 p.m. - 4:15 p.m. |
O-013: Single Cell Transcriptomes From Uterine Fibroids and Fibroid-Free Myometrium Elucidate Myometrial Tumorigenesis |
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4:15 p.m. - 4:30 p.m. |
O-014: Effect of Selective Progesterone Receptor Modulator (SPRM), Ulipristal Acetate (UPA) on Uterine and Fibroid Volume Measured by Unbiased Stereology and MRI |
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4:30 p.m. - 4:45 p.m. |
O-015: Nintedanib Alters Hippo Signaling in Uterine Fibroid Cells Leading to Decreased Levels of Connective Tissue Growth Factor and Cyclin D1, and Reduced Fibroid Cell Proliferation |
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4:45 p.m. - 5:00 p.m. |
O-016: Association Between Anxiety/Depression, Uterine Fibroid Symptomology and Health Status Among Women Undergoing Interventional Treatments for Uterine Fibroids |
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5:00 p.m. - 5:15 p.m. |
O-017: Gene Expression Analysis of Foreign Body Response to Engineered Nano-Mesh with Endometrial Stem/Stromal Cells for Pelvic Organ Prolapse Repair |
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5:15 p.m. - 5:30 p.m. |
O-018: Urogynecologic Mesh Complications: Low FGF Suggests Impaired Wound Healing |
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5:30 p.m. - 5:45 p.m. |
O-019: Euploid Miscarriage is Associated with Lactobacillus spp. Deplete Vaginal Microbial Composition and Local Inflammation |
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5:45 p.m. - 6:00 p.m. |
O-020: Pregnancy Outcomes Following Routine Early Provision of IUD After First Trimester Induced Abortion - 5-year Follow-up of a Randomized Controlled Trial |
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Parturition I |
EAST MEETING ROOM 8 & 15 - VCC EAST LEVEL 2 |
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4:00 p.m. - 4:15 p.m. |
O-021: Evaluating Cervical Remodeling in Preterm and Term Birth Mouse Models with in vivo Raman Spectroscopy |
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4:15 p.m. - 4:30 p.m. |
O-022: Polarized Light Imaging of the Pregnant Cervix |
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4:30 p.m. - 4:45 p.m. |
O-023: In vivo Diffusion Tensor Imaging of the Cervix Early and Late in Normal Pregnancy |
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4:45 p.m. - 5:00 p.m. |
O-024: Essential Roles of Uterine Peristalsis by Cav1.2 in Reproduction and Adenomyosis in Mice |
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5:00 p.m. - 5:15 p.m. |
O-025: NF-кB and AP-1 Transcription Factors Regulate Human 20 alpha HSD Transcription: Potential Pathways to Labour Induction |
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5:15 p.m. - 5:30 p.m.. |
O-026: Dynamic MicroRNA 203 Expression Regulates Myometrial Smooth Muscle Cell Transient Receptor Vanilloid 4 Channel Expression During Pregnancy |
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5:30 p.m. - 5:45 p.m. |
O-027: Regulation of Mouse Uterine Contractility by Regulator of G-Protein Signalling 2 |
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5:45 p.m. - 6:00 p.m. |
O-028: Differential Regulation of SOX Family Transcription Factors in the Pregnant and Labouring Mouse Myometrium |
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Placenta I |
EAST MEETING ROOM 11 & 12 - VCC EAST LEVEL 2 |
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4:00 p.m. - 4:15 p.m. |
O-029: Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes |
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4:15 p.m. - 4:30 p.m. |
O-030: Under-Expression of Placental Endocrine-Specific Igf2 Programmes Cardiovascular Disease in the Adult Male Offspring |
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4:30 p.m. - 4:45 p.m. |
O-031: Nanoparticle-Mediated Transgene Expression of Insulin-like Growth Factor in the Guinea Pig Placenta Reduces Angiogenic Factor Transcription but Enhances Glucose Transporter Expression |
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4:45 p.m. - 5:00 p.m. |
O-032: Regulatory T Cells Determine Uterine Natural Killer Cell Abundance and Decidual Vascular Remodeling in Early Pregnancy in Mice |
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5:00 p.m. - 5:15 p.m. |
O-033: Novel Placental Cell Defense Against Lipotoxicity-induced Ferroptotic Death |
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5:15 p.m. - 5:30 p.m. |
O-034: Role of Toll-Like Receptor 8 (TLR8) in the Inflammatory Response to Virus in Hofbauer Cells (HBCs) |
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5:30 p.m. - 5:45 p.m. |
O-035: Less is More! Commensal Microbiome Supports Macrophage-Trophoblast-Interaction |
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5:45 p.m. - 6:00 p.m. |
O-036: Derivation of Human Trophoblast Stem Cells from Pluripotent Stem Cells to Model Early Placental Development |
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Maternal Biology and Health |
EAST MEETING ROOM 13 – VCC EAST LEVEL 2 |
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4:00 p.m. - 4:15 p.m. |
O-037: The Influence of Artificial Sweetener During Pregnancy on Long Term Maternal Health |
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4:15 p.m. - 4:30 p.m. |
O-038: Mechanisms of Action of Intervention in the PHOENIX Trial: In Women with Preterm Preeclampsia Does Planned Delivery Improve Postpartum Maternal Cardiac Function Through Attenuation of Myocardial Ischaemia at Time of Disease (PHOEBE Study)? |
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4:30 p.m. - 4:45 p.m. |
O-039: Maternal Obesity During Pregnancy Induces Oxidative Stress and Mitochondria Functional Alterations in the Maternal Liver |
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4:45 p.m. - 5:00 p.m. |
O-040: 10 Years Prediction Model for Chronic Hypertension AfterPreeclampsia in Initially Normotensive Women |
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5:00 p.m. - 5:15 p.m. |
O-041: Postpartum Hemorrhage After Vaginal Delivery is Associated with a Decrease in Immediate Breastfeeding Success |
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5:15 p.m. - 5:30 p.m. |
O-042: Changes in Maternal Gut Microbiome Diversity and Composition Associated with Infant Feeding Behaviors |
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5:30 p.m. - 5:45 p.m. |
O-043: Prenatal Maternal Stress Induces Preterm Birth and Impacts Neonatal Adaptive Immunity |
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5:45 p.m. - 6:00 p.m. |
O-044: Association of Pre-pregnancy Subclinical Insulin Resistance With Cardiac Dysfunction in Healthy Nulliparous Women |
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Reproductive Biology I |
EAST MEETING ROOM 3 – VCC EAST LEVEL 2 |
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4:00 p.m. - 4:15 p.m. |
O-045: Towards Three-Dimensional Imaging of the Murine Vagina |
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4:15 p.m. - 4:30 p.m. |
O-046: Proteomic Analysis of Secretions from a Novel Endocervical Cell Culture Using Conditionally Reprogrammed Cells |
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4:30 p.m. - 4:45 p.m. |
O-047: Differentiation of Mouse iPSCs into Functional Oocytes |
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4:45 p.m. - 5:00 p.m. |
O-048: Mitochondrial Stress Response Gene Clpp is Not Required for Granulosa Cell Function |
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5:00 p.m. - 5:15 p.m. |
O-049: Exposure to Synthetic Glucocorticoids Modifies the Sperm MicroRNA Profile: Implications for Intergenerational Transmission |
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5:15 p.m. - 5:30 p.m. |
O-050: Recombinant AMH (rAMH) for Stalling in vitro Granulosa Cell Replication |
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5:30 p.m. - 5:45 p.m. |
O-051: Loss of Ovarian Expression of the Noncoding RNA H19 Promotes Susceptibility to Doxorubicin-induced DNA Damage |
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5:45 p.m. - 6:00 p.m. |
O-052: Metabolomics Study of Mouse Blastocysts Cultured in a Microfluidic Device to Assess Development in Uterine Cell-Conditioned Media |
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6:15 p.m. - 7:45 p.m. |
Connection Corners |
EAST MEETING ROOM 1 - VCC EAST LEVEL 2
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7:00 a.m. - 6:00 p.m. |
Registration |
LOBBY - VCC EAST LEVEL 1 |
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7:00 a.m. - 8:00 a.m. |
SRI Business Meeting |
EAST MEETING ROOM 1 - VCC EAST LEVEL 2 |
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8:00 a.m. - 8:30 a.m. |
Grant Program Recipient Presentations |
EAST BALLROOM BC - VCC EAST LEVEL 1 |
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8:00 a..m - 8:15 a.m. |
Investigation of Genome Wide DNA Methylation Changes in Mouse Embryos Associated with Superovulation |
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8:15 a.m. - 8:30 a.m. |
Unraveling the Consequences of Elevated Advanced Glycation End Product Levels on Female Fertility Jemma Evans, PhD |
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8:30 a.m. - 9:30 a.m. |
EAST BALLROOM BC - VCC EAST LEVEL 1 |
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Viral Noncoding RNAs: Approaching Answers |
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9:30 a.m. - 11:00 a.m. |
Poster Session II |
EAST EXHIBIT HALL B - VCC EAST LEVEL 1 |
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11:00 a.m. - 12:30 p.m. |
Concurrent Oral Presentations II |
VARIOUS ROOMS |
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Developmental Programming I |
EAST MEETING ROOM 13 – VCC EAST LEVEL 2 |
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11:00 a.m. - 11:15 a.m. |
O-053: Sex-specific Alterations in the Early Embryonic Mouse Epigenome |
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11:15 a.m. - 11:30 a.m.p> |
O-054: A Life Course Approach to the Relationship Between Fetal Growth and HPA-Axis Function |
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11:30 a.m. - 11:45 a.m. |
O-055: Sex-Specific Effects of a Placenta-Targeted Treatment with nMitoQ on the Mechanisms of Cardiac Dysfunction in Adult Offspring Exposed to Hypoxia in utero |
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11:45 a.m. - 12:00 p.m. |
O-056: Perinatal Protein Deficiency and Postnatal Catch-up Growth Leads to Hepatic Mitochondrial Dysfunction in Adult IUGR Offspring |
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12:00 p.m. - 12:15 p.m. |
O-057: Iron Restriction During Pregnancy Causes Dysfunction and Morphological Changes in the Hearts of Neonatal Offspring |
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12:15 p.m. - 12:30 p.m. |
O-058: Epigenetic Effects of N-acetylcysteine on H2S-Mediated Protection Against Fetal Origins of Vascular Disease |
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Fetus I |
EAST MEETING ROOM 3 – VCC EAST LEVEL 2 |
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11:00 a.m. - 11:15 a.m. |
O-059: PiggyBac Transposase Mediated Inducible Trophoblast-specific Knockdown of Mechanistic Target of Rapamycin (mTOR) in Mice Decreases Placental Nutrient Transport and Inhibits Fetal growth |
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11:15 a.m. - 11:30 a.m.p> |
O-060: Effects of Nanoparticle-encapsulated MitoQ (nMitoQ) Delivery to the Placenta on Fetal Cardiomyocyte Development in a Rat Model of Prenatal Hypoxia |
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11:30 a.m. - 11:45 a.m. |
O-061: Exploring Genetic Variation in Normal and Diseased Human Placentas |
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11:45 a.m. - 12:00 p.m. |
O-062: An Aberrant Endothelial Cell Response to Flow: Mechanistic Implications for Congenital Heart Defects in the Feto-placental Unit |
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12:00 p.m. - 12:15 p.m. |
O-063: Low Dose Insulin Infusion in IUGR Fetal Sheep Stimulates Skeletal Myoblast Proliferation but Not Fiber Number |
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12:15 p.m. - 12:30 p.m. |
O-064: Decreased Mitochondrial Complex I Activity in Skeletal Muscle of Growth Restricted Ovine Fetuses with Placental Insufficiency |
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Preeclampsia I |
EAST MEETING ROOM 11 & 12 – VCC EAST LEVEL 2 |
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11:00 a.m. - 11:15 a.m. |
O-065: Proinflammatory and Anti-inflammatory Cytokine Responses by Decidua T Cells in Preeclampsia |
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11:15 a.m. - 11:30 a.m.p> |
O-066: Sulforaphane Improves Vascular Reactivity in Arteries After Preeclamptic-like Injury |
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11:30 a.m. - 11:45 a.m. |
O-067: Progesterone Induced Blocking Factor Attenuates Hypertension, Placental and Endothelial Cell Mitochondrial Dysfunction and Reactive Oxygen Species in Response to sFlt-1 During Pregnancy |
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11:45 a.m. - 12:00 p.m. |
O-068: Challenging the Definition of Hypertension in Pregnancy - A Retrospective Cohort Study |
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12:00 p.m. - 12:15 p.m. |
O-069: Hypoxic Pregnancy Recapitulates In Vivo, Mitochondrial and Molecular Markers of Preeclampsia in the Mother, Placenta and Offspring |
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12:15 p.m. - 12:30 p.m. |
O-070: Surgically Increasing Uteroplacental Impedance Results in Attenuated Uterine Vascular Remodeling and Preeclampsia-Related Placental Secretomics During Pregnancy |
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Gynecology II |
EAST BALLROOM BC – VCC EAST LEVEL 1 |
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11:00 a.m. - 11:15 a.m. |
O-071: Endometriosis Lesion-specific cxcr4 Knockdown Increases Estrous-cycle Dependent Intraepithelial Lymphocyte Infiltration in the Mouse, Compromising Lesion Integrity |
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11:15 a.m. - 11:30 a.m.p> |
O-072: Targeting and Treatment of Endometriosis with Nanoparticles |
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11:30 a.m. - 11:45 a.m. |
O-073: Large-scale Genome-wide Association Meta-analysis of Endometriosis Reveals 44 Loci in 61K Cases and 711K Controls and Genetically-associated Comorbidity with Other Pain Conditions |
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11:45 a.m. - 12:00 p.m. |
O-074: Microvascular Endothelium-Dependent Vasodilation is Impaired in Women with Endometriosis and Improved with Acute Atorvastatin Treatment |
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12:00 p.m. - 12:15 p.m. |
O-075: Identification ofFOXC1as a Key Transcriptional Regulator in Induced Endometriosis Lesions |
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12:15 p.m. - 12:30 p.m. |
O-076: Spontaneous Ovarian Endometriosis in Mice with Deletion of Arid1a and Gain of KrasG12D |
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Parturition II |
EAST MEETING ROOM 8 & 15 – VCC EAST LEVEL 2 |
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11:00 a.m. - 11:15 a.m. |
O-077: Lung Maturation in Extremely Preterm Fetal Lambs Maintained on an Artificial Placenta is Driven by Glucocorticoid Signalling, Not Inflammation |
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11:15 a.m. - 11:30 a.m.p> |
O-078: A Novel Allosteric Modulator of IL-6R Successfully Prevents Deleterious Effects of Inflammation in a LPS Model of Preterm Birth |
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11:30 a.m. - 11:45 a.m. |
O-079: Enhanced Decidual FKBP51 Expression Promotes Idiopathic Preterm Birth by Inducing Functional Progesterone Withdrawal |
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11:45 a.m. - 12:00 p.m. |
O-080: Selective Progesterone Receptor Modulator Delays Term Labor and Prevents Preterm Labor in Mice |
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12:00 p.m. - 12:15 p.m. |
O-081: Multi-Omic, Longitudinal Profile of Third-Trimester Pregnancies Identifies a Molecular Switch That Predicts the Onset of Labor |
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12:15 p.m. - 12:30 p.m. |
O-082: Association Between Daily Melatonin and Cortisol Rhythms and Risk of Preterm Birth |
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Reproductive Endocrinology and Infertility I |
EAST MEETING ROOM 2 – VCC EAST LEVEL 2 |
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11:00 a.m. - 11:15 a.m. |
O-083: An In Vivo Model of Human FSH Dysregulation in Obesity: Obese Women Exhibit Lower Serum FSH Levels in Response to Intravenous Recombinant FSH After GnRH Suppression |
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11:15 a.m. - 11:30 a.m.p> |
O-084: A Multi-Center, Prospective, Blinded, Non-Selection Study Evaluating the Predictive Value (PV) of an Aneuploid Preimplantation Genetic Testing for Aneuploidy (PGT-A) Diagnosis and Impact of Biopsy |
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11:30 a.m. - 11:45 a.m. |
O-085: Identification of Novel PRDM9 DNA Binding Alleles in an Azoospermia Cohort |
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11:45 a.m. - 12:00 p.m. |
O-086: A Superovulatory Uterine Environment Impacts Embryo Implantation, Results in Placental ER Stress and Reduces Fetal Growth of Both Fresh and Vitrified Embryos |
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12:00 p.m. - 12:15 p.m. |
O-087: Anti Mullerian Hormone is Low in Women with Sickle Cell Disease Who Participated in the Multi-Center Study of Hydroxyurea |
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12:15 p.m. - 12:30 p.m. |
O-088: Different Origins of Sperm and the Impact on Prenatal and Placental Growth Trajectories: The Rotterdam Periconception Cohort |
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12:35 p.m. - 2:05 p.m. |
Diversity, Equity and Inclusion Forum |
EAST MEETING ROOM 1 – VCC EAST LEVEL 2 |
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Moderator: |
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People Like You Can’t Do That |
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12:35 p.m. - 2:05 p.m. |
Lunch and Learn Symposium III |
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Don't Get Lost in Translation: Importance of In Vivo and In Vitro Model Validation |
EAST MEETING ROOM 11&12 – VCC EAST LEVEL 2 |
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12:35 p.m. - 1:20 p.m. |
Back-Translation of Clinical Endpoints and Model Validation in Preclinical Research (fibroids examples) |
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1:20 p.m. - 2:05 p.m. |
Modeling Artificial Ovary |
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2:10 p.m. - 4:10 p.m. |
Concurrent Mini-Symposia II |
VARIOUS ROOMS |
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Controversies: Yes or No for Placental Microbiome |
EAST BALLROOM BC - VCC EAST LEVEL1 |
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2:10 p.m. - 2:40 p.m. |
Panelist 1: |
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2:40 p.m. - 3:10 p.m. |
Panelist 2: |
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3:10 p.m. - 3:40 p.m. |
Panelist 3: |
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3:40 p.m. - 4:10 p.m. |
Panelist 4: |
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Reproduction Meets Imaging |
EAST MEETING ROOM 13 - VCC EAST LEVEL 2 |
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2:10 p.m. - 2:40 p.m. |
In Vivo Imaging of Reproductive Dynamics in the Mouse Oviduct |
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2:40 p.m. - 3:10 p.m. |
Active Fluctuations Modulate Nuclear Dynamics in Oocytes |
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3:10 p.m. - 3:40 p.m. |
Quantitative Ultrasound of the Cervix in Pregnancy: Today & Tomorrow |
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3:40 p.m. - 4:10 p.m. |
Preventing Postpartum Depression: An Intergenerational fMRI Clinical Trial |
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SRI – SSR Joint Session: Immune Cell Regulation of Implantation/Pregnancy |
EAST MEETING ROOM 8 & 15 - VCC EAST LEVEL 2 |
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2:10 p.m. - 2:40 p.m. |
Neutrophils at the Maternal-Fetal Interface: Friend or Foe? |
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2:40 p.m. - 3:10 p.m. |
The Stage Is Set Before the Play Commences – Maternal Immunological Detection of the Conceptus |
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3:10 p.m. - 3:40 p.m. |
Maternal Immunity and Tolerance During Pregnancy |
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3:40 p.m. - 4:10 p.m. |
Fetal-Maternal Disagreement: Immune Responses in Placental Villitis |
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SRI – PRS Joint Session: Interaction at the Maternal-Fetal Interface and Origins of Child Health and Disease |
EAST MEETING ROOM 11 & 12 - VCC EAST LEVEL 2 |
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2:10 p.m. - 2:40 p.m. |
Implications of Immunoperinatology Research on Neonatal and Lifetime Health |
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2:40 p.m. - 3:10 p.m. |
Multidisciplinary, Multiplatform Approaches to Unravel the Mechanisms of Adverse Pregnancy Outcomes |
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3:10 p.m. - 3:40 p.m. |
Next Frontiers in Vesicle-Based Placental-Maternal-Fetal Communication |
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3:40 p.m. - 4:10 p.m. |
Gaps in Knowledge in Understanding the Immunobiology and Immunopathology of Pregnancy and Future Directions |
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Drivers and Therapeutic Targets for Gynecologic Cancers Associated with Benign Gynecologic Conditions |
EAST MEETING ROOM 3 - VCC EAST LEVEL 2 |
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2:10 p.m. - 2:40 p.m. |
ARID1A as a Driver and Target for Therapy for Endometriosis-Associated Ovarian Cancer (Implications for Immunotherapy) |
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2:40 p.m. - 3:10 p.m. |
Toxicant Exposure, Endocrine Disruptors and Adenomyosis (Environmental Influence) |
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3:10 p.m. - 3:40 p.m. |
The Insulin/Insulin Growth Factor and Sex Hormone Axes in the Normal Endometrium and in Tumor Microenvironment of Endometrial Cancer (Environmental Influence of Obesity and Implications for Immunotherapy) |
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3:40 p.m. - 4:10 p.m. |
Mouse Models of Endometriosis-Associated Gynecologic Cancers |
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Stem Cell Therapy of Reproductive Disorders |
EAST MEETING ROOM 2 - VCC EAST LEVEL 2 |
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2:10 p.m. - 2:40 p.m. |
Opportunities and Challenges in Regenerative Therapies |
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2:40 p.m. - 3:10 p.m. |
Stem Cell and Gene Therapy of Ovarian Infertility: from Bench to Rodents to Women, and Back |
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3:10 p.m. - 3:40 p.m. |
Cell Therapy of Asherman Syndrome and Endometrial Atrophy |
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3:40 p.m. - 4:10 p.m. |
Cell Therapy of Male Infertility |
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4:10 p.m. - 4:25 p.m. |
Coffee Break |
FOYER SOUTH |
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4:30 p.m. - 6:00 p.m. |
Concurrent Oral Presentations III |
VARIOUS ROOMS |
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Epidemiology and Global Health |
EAST MEETING ROOM 1 – VCC EAST LEVEL 2 |
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4:30 p.m. - 4:45 p.m. |
O-089: Likelihood of Women Achieving More Than One Live Birth After Various Types of Cancers |
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4:45 p.m. - 5:00 p.m. |
O-090: Women with History of Pregnancy Complications Have Higher Risk of Midlife Stroke: The PATH Study |
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5:00 p.m. - 5:15 p.m. |
O-091: Analysis of Fetal Birth Weight Percentiles at Birth Improves Our Understanding of How the Maternal Postpartum Phenotype is Linked to Poor Pregnancy Outcome |
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5:15 p.m. - 5:30 p.m. |
O-092: Losing Specificity. The Unintended Harm of Improved Detection of Fetal Growth Restriction |
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5:30 p.m. - 5:45 p.m. |
O-093: Racial Disparities in Infant Mortality Following Singleton Pregnancies in the US |
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5:45 p.m. - 6:00 p.m. |
O-094: Confidential Review of Maternal Deaths in the Community Level Interventions for Pre-Eclampsia Pakistan Trial |
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Development Programming II |
EAST MEETING ROOM 2 – VCC EAST LEVEL 2 |
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4:30 p.m. - 4:45 p.m. |
O-095: Maternal Adiposity Alters Hippocampal Epigenomic and Transcriptomic Profiles in the Fetal Baboon |
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4:45 p.m. - 5:00 p.m. |
O-096: Sexual Dimorphic Mechanisms of Programming of Adipose Tissue (AT) Expansion by Maternal Obesity (MO) in the Rat |
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5:00 p.m. - 5:15 p.m. |
O-097: Pronuclear Transfer Reveals Oocyte Nucleus is Sufficient to Transmit Cardiac Mitochondrial Abnormalities in Offspring of Obese Dams |
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5:15 p.m. - 5:30 p.m. |
O-098: Maternal Obesity (MO) in Sheep Elevates Fetal Left Ventricular (LV) Tissue Cortisol Concentration and the Components of the 11βhydroxysteroid Dehydrogenase (11βHSD1) System at Term |
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5:30 p.m. - 5:45 p.m. |
O-099: Females Are Not Just ‘Protected’ Males: Sex-Specific Vulnerabilities In Placenta and Brain After Prenatal Immune Disruption |
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5:45 p.m. - 6:00 p.m. |
O-100: Maternal Obesity Diminishes Inhibitory Interneuron Function in Rat Hippocampus |
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Reproductive Biology II |
EAST MEETING ROOM 3 – VCC EAST LEVEL 2 |
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4:30 p.m. - 4:45 p.m. |
O-101: The Role of Sirt1 and Progesterone Resistance in Normal and Abnormal Uterine Physiology: A Novel Hypothesis |
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4:45 p.m. - 5:00 p.m. |
O-102: Extracellular Vesicles Secreted by Uterine Decidual Cells Carry Critical Information for Establishment of Pregnancy |
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5:00 p.m. - 5:15 p.m. |
O-103: Loss of MIG-6 Results in Endometrial Progesterone Resistance and Endometriosis-related Infertility Through ERBB2 Overexpression |
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5:15 p.m. - 5:30 p.m. |
O-104: Endometrial Mitochondrial DNA Secreted in Extracellular Vesicles: A Novel Mechanism Modulating Maternal-Embryo Bioenergetics |
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5:30 p.m. - 5:45 p.m. |
O-105: Entosis Occurs in Human Embryo Implantation |
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5:45 p.m. - 6:00 p.m. |
O-106: MicroRNA Expression in Pregnancy of Unknown Location (PUL) |
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Placenta II |
EAST MEETING ROOM 11 & 12 – VCC EAST LEVEL 2 |
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4:30 p.m. - 4:45 p.m. |
O-107: Placental Genomic Imbalances Contribute to Poor Fetal Growth: From Trisomy to Copy Number Variants |
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4:45 p.m. - 5:00 p.m. |
O-108: Transcription Factor NRF2 Serves a Key Role in the Expression of Immune Modulators During Human Trophoblast Differentiation |
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5:00 p.m. - 5:15 p.m. |
O-109: Placental Cell-specific Extracellular Vesicle Profiles from Syncytiotrophoblasts and Extravillous Trophoblasts in the First Trimester |
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5:15 p.m. - 5:30 p.m. |
O-110: Bi-directional Signaling Between Placental Endothelial Cells and Extracellular Matrix Regulates Fetoplacental Angiogenesis in Severe Fetal Growth Restriction |
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5:30 p.m. - 5:45 p.m. |
O-111: Identifying Metabolite Signatures in Placental Development Using iHumanPlacenta Metabolic Network |
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5:45 p.m. - 6:00 p.m. |
O-112: Trophoblast Derived Soluble-PDL1 Modulates Macrophage Polarization and Function |
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Reproductive Endocrinology and Infertility II |
EAST MEETING ROOM 8 & 15 – VCC EAST LEVEL 2 |
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4:30 p.m. - 4:45 p.m. |
O-113: Exposure to D-galactose is Not Embryotoxic |
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4:45 p.m. - 5:00 p.m. |
O-114: Examination of Androgen Effects on Female Reproductive Axis: Hypothalamus-Pituitary-Ovary |
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5:00 p.m. - 5:15 p.m. |
O-115: Mild hyperandrogenemia in Presence/Absence of a High-fat, Western-style Diet Alters Secretory Phase Endometrial Transcriptome in Nonhuman Primates |
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5:15 p.m. - 5:30 p.m. |
O-116: Effect of Mitochondrial Dynamin Like GTPase on Steroidogenesis in the Corpus Luteum |
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5:30 p.m. - 5:45 p.m. |
O-117: Bioavailable Inhibin B May be a Better Marker of Oocyte Yield Than Ovarian Reserve |
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5:45 p.m. - 6:00 p.m. |
O-118: Dose-Dependent Ovulation Rates and Endocrine Correlates of Ovulation in PCOS Patients Undergoing Letrozole Ovulation Induction: A Secondary Analysis of the PPCOSII Trial |
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Clinical and Translational Perinatology II |
EAST MEETING ROOM 13 – VCC EAST LEVEL 2 |
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4:30 p.m. - 4:45 p.m. |
O-119: First Use of an Artificial Placenta to Support Extremely Preterm Sheep Fetuses Compromised by Intrauterine Inflammation |
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4:45 p.m. - 5:00 p.m. |
O-120: Fetal Rh Antigen is Present Consistently Throughout Cells in the Maternal Circulation in Early Pregnancy |
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5:00 p.m. - 5:15 p.m. |
O-121: Individual Edinburg Perinatal Depression Scale (EPDS) Components and Preterm Birth |
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5:15 p.m. - 5:30 p.m. |
O-122: Racial and Ethnic Disparities in Mode of Delivery During Labor Induction |
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5:30 p.m. - 5:45 p.m. |
O-123: Maternal and Neonatal Morbidity Associated With TOLAC Versus Elective Repeat Cesarean as a Function of VBAC Success Prediction |
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5:45 p.m. - 6:00 p.m. |
O-124: Maternal and Neonatal Morbidity Following Uterine Rupture by History of Previous Cesarean Section |
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6:15 p.m. - 7:30 p.m. |
President's Address and Awards Ceremony |
EAST BALLROOM BC - VCC EAST LEVEL 1 |
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7:45 p.m. - 11:00 p.m. |
The Featles Canadian Tour |
EAST BALLROOM A - VCC EAST LEVEL 1 |
7:00 a.m. - 1:45 p.m. |
Registration |
LOBBY - VCC EAST LEVEL 1 |
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8:00 a.m. - 9:00 a.m. |
EAST BALLROOM BC - VCC EAST LEVEL 1 |
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Modeling Early Placental Development – Can Pluripotent Stem Cells Do the Trick? |
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9:00 a.m. - 10:30 a.m. |
Poster Session III |
EAST EXHIBIT HALL B - VCC EAST LEVEL 1 |
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10:30 a.m. - 12:00 p.m. |
Concurrent Oral Presentations IV |
VARIOUS ROOMS |
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Fetus II |
EAST MEETING ROOM 13 – VCC EAST LEVEL 2 |
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10:30 a.m. - 10:45 a.m. |
O-125: Late Gestation Fetal Hyperglucagonemia Results in Lower Fetal Weight, Fetal Hypoaminoacidemia, and Decreased Uteroplacental Nutrient Uptake |
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10:45 a.m. - 11:00 a.m. |
O-126: Intrauterine Hypoxia Induces Compensatory Changes in Fetal Heart Function in Growth Restricted Fetuses in a Sex Dependent Manner |
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11:00 a.m. - 11:15 a.m. |
O-127: Maternal and Fetal Immunological Consequences of Intrauterine Inflammation: Implications for Fetal Brain Injury |
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11:15 a.m. - 11:30 a.m.p> |
O-128: Novel Gasotransmitter Cardio-Protection in the Developing Heart: Comparative Roles of Hydrogen Sulphide and Carbon Monoxide |
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11:30 a.m. - 11:45 a.m. |
O-129: Human Microglia Acquire a More Mature, Homeostatic Phenotype During the Transition of the First and Second Trimester of Gestation |
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11:45 a.m. - 12:00 p.m. |
O-130: Bacterial and Viral Infections Inhibit Defence Mechanisms in the Developing Human Blood-Brain Barrier (BBB) in Vitro |
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Parturition III |
EAST MEETING ROOM 8 & 15 – VCC EAST LEVEL 2 |
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10:30 a.m. - 10:45 a.m. |
O-131: Extracellular Calcium Entry via the TRPV4 Channel Potentiates NFκB Activation in the Myometrium |
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10:45 a.m. - 11:00 a.m. |
O-132: Synthetic PreImplantation Factor (sPIF) Prevents Preterm Birth and Preserves Fetal Brain Development |
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11:00 a.m. - 11:15 a.m. |
O-133: Exosomal Delivery of NF-kB Inhibitor Delays LPS-Induced Preterm Birth and Reduces Fetal Inflammatory Response in Mouse Models |
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11:15 a.m. - 11:30 a.m.p> |
O-134: The Vaginal Immune Response, the Microbiome, and Their Interactions in Women Who Ultimately Deliver Preterm or at Term |
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11:30 a.m. - 11:45 a.m. |
O-135: Microbial Metabolites Compromise Epithelial Barrier Integrity: Potential Mechanisms by Which Non-Optimal Cervicovaginal Microbiota Lead to Preterm Birth |
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11:45 a.m. - 12:00 p.m. |
O-136: Fetal Membrane-Activated Neutrophils Propagate Fetal Membrane Inflammation and Markers of Membrane Weakening |
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Placenta III |
EAST MEETING ROOM 11 & 12 – VCC EAST LEVEL 2 |
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10:30 a.m. - 10:45 a.m. |
O-137: In Vivo Impact of Chorionic Somatomammotropin RNA Interference in the Absence of Intrauterine Growth Restriction |
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10:45 a.m. - 11:00 a.m. |
O-138: Identification of Placental MiRNA Associated with Maternal Insulin Sensitivity During Pregnancy |
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11:00 a.m. - 11:15 a.m. |
O-139: Changes in Lipid Profiles of Placental Exosomes in Maternal Plasma Characterize Pregnancies with a Small-for-Gestational Age Fetus |
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11:15 a.m. - 11:30 a.m. |
O-140: Azithromycin Treatment of Placental Inflammation in a Non-Human Primate Model of Intra-Amniotic Ureaplasma Infection |
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11:30 a.m. - 11:45 a.m. |
O-141: MRI Compatible Ex-vivo Human Whole Placenta Dual Perfusion System |
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11:45 a.m. - 12:00 p.m. |
O-142: Circulating CD31+ Exosomes From Pregnant Women with Placenta Accreta Spectrum Stimulate Uterine Angiogenesis and Trophoblast Differentiation and Invasion |
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Reproductive Biology III |
EAST MEETING ROOM 2 – VCC EAST LEVEL 2 |
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10:30 a.m. - 10:45 a.m. |
O-143: G-CSF Mobilized Plasma Regenerate Ovarian Stroma and Restore Ovarian Function |
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10:45 a.m. - 11:00 a.m. |
O-144: Modeling Preeclampsia Using Human Induced Pluripotent Stem Cells |
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11:00 a.m. - 11:15 a.m. |
O-145: Pluripotent Stem Cell Derived Endometrial Mesenchyme and Decidual Epithelium Form a 3-Dimensional Model of the Human Endometrium |
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11:15 a.m. - 11:30 a.m.p> |
O-146: A Single-cell RNA-Seq Survey of Mouse Implantation Site Mapping the Contribution of Maternal Exogenous Bone Marrow Cells to Decidua |
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11:30 a.m. - 11:45 a.m. |
O-147: miR-155 Deficiency Impairs Pregnancy Tolerance and Predisposes to Inflammation-Induced Fetal Loss in Mice |
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11:45 a.m. - 12:00 p.m. |
O-148: Human Regulatory T Cells at the Maternal-Fetal Interface Show Functional Site-Specific Adaptation with Tumor-Infiltrating-Like Features |
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Preeclampsia II |
EAST MEETING ROOM 1 – VCC EAST LEVEL 2 |
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10:30 a.m. - 10:45 a.m. |
O-149: Can WS1442 Ameliorate Maternal Vascular Dysfunction in Preeclampsia? |
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10:45 a.m. - 11:00 a.m. |
O-150: Effect of Pregnancy Prolongation in Early-Onset Preeclampsia on Remote Maternal Cardiovascular, Renal and Metabolic Function |
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11:00 a.m. - 11:15 a.m. |
O-151: Using Machine Learning Tools to Classify and Predict Preeclampsia in Asymptomatic Women |
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11:15 a.m. - 11:30 a.m.p> |
O-152: Galectin-7: A Novel Placental-released Driver of Preeclampsia |
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11:30 a.m. - 11:45 a.m. |
O-153: The New Generation Antiplatelet Agent Prasugrel Represents an Exciting Novel Candidate Therapy for Preeclampsia |
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11:45 a.m. - 12:00 p.m. |
O-154: Identification of Subtype-specific Markers for Preeclampsia Using Placental Pathology and RNAseq |
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Gynecologic Oncology |
EAST MEETING ROOM 3 – VCC EAST LEVEL 2 |
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10:30 a.m. - 10:45 a.m. |
O-155: Evaluation of ATR Inhibitors for Targeted Therapy of Ovarian Clear Cell Carcinoma |
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10:45 a.m. - 11:00 a.m. |
O-156: The Expression of FKBP5 is Important to Overcome Progesterone Resistance in Endometrial Hyperplasia |
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11:00 a.m. - 11:15 a.m. |
O-157: Identifying a Potential Biomarker for Anti-PD-1 Immunotherapy in Patients with Advanced Stage, Surgically-Resectable Endometrial Cancer |
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11:15 a.m. - 11:30 a.m.p> |
O-158: Excess Adiposity Induces Intrauterine Cytochrome P450 Expression in Mice |
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11:30 a.m. - 11:45 a.m. |
O-159: Differential Sensitivity to the PARP Inhibitor Niraparib vs Olaparib in Homologous Recombination Proficient (HRP) Uterine Serous Carcinoma Cell Lines |
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11:45 a.m. - 12:00 p.m. |
O-160: Genetic Relationship Between Endometriosis and Ovarian Cancer Subtypes |
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12:05 p.m. - 1:35 p.m. |
Hot Topics and Awards Ceremony |
EAST BALLROOM BC - VCC EAST LEVEL 1 |