SRI 64th Annual Scientific Meeting
SRI 64th Annual Scientific Meeting

Society of Reproductive Investigation (SRI)

64th Annual Scientific Meeting, March 15-18, 2017

Tuesday, March 14

2:00 p.m. - 7:00 p.m.

Registration

Bonnet Creek Foyer

2:00 p.m. - 6:00 p.m.

SRI Council Meeting

Manatee

Wednesday, March 15

7:00 a.m. - 7:00 p.m.

Registration

Bonnet Creek Foyer

7:30 a.m. - 8:30 a.m. (Breakfast served at 7:00 a.m.)

Career Development Session - Mid-Career Researcher
Navigating a Changing Landscape: Mid-Career in Reproductive Science

Moderators:
Elizabeth A. Bonney, MD, MPH
Jared Robins, MD

Changes in both medicine and science have created unique challenges and opportunities for a mid-career professional in reproductive science.  The purpose of this event is to bring together those who consider themselves at mid-career to 1) define these challenges and opportunities and 2) determine what steps need to be taken and what resources need to be developed or leveraged to meet these challenges and assist mid-career professionals to continue or refine their career paths.  The discussion content will be developed into a white paper to be shared in the SRI journal, Reproductive Sciences.

Floridian E - F

8:30 a.m. - 5:00 p.m.

Endometrium Satellite Meeting

Floridian C

8:30 a.m. - 5:00 p.m.

Fetal Physiology Satellite Meeting

Bonnet Creek X

8:30 a.m. - 5:00 p.m.

Myometrium/Parturition Satellite Meeting

Floridian B

8:30 a.m. - 5:00 p.m.

Ovarian Biology Satellite Meeting

Floridian A

8:30 a.m. - 5:00 p.m.

Placenta Satellite Meeting

Bonnet Creek XI

8:30 a.m. - 5:00 p.m.

Preterm Birth Satellite Meeting

Bonnet Creek XII

12:15 p.m. - 1:15 p.m.

Career Development Session - Diversity
Maps Where Children Matter
Marie Lynn Miranda, PhD
Rice University

This talk will cover how geospatial health informatics can be used to elucidate the role of social and environmental stressors in shaping outcomes for pregnant women and children.

Floridian E - F

12:00 p.m. - 1:00 p.m.

Reproductive Sciences Editorial Board Meeting

Orange

5:15 p.m. - 6:45 p.m.

Career Development Session - New Investigator & Early Career
Job Search and Negotiation

Facilitator: Sascha Drewlo, PhD

Floridian A

5:15 p.m. - 5:20 p.m.

Welcome
Yolanda Smith, MD, MS

5:20 p.m. - 5:35 p.m.

Introduction and Session Objectives
Sascha Drewlo, PhD

5:35 p.m. - 5:45 p.m.

Role Play: Negotiation Process
Marie Lynn Miranda, PhD
Hugh Taylor, MD

5:45 p.m. - 6:15 p.m.

Discussion: The Good, the Bad, and the Ugly Side of the Negotiation Process & Panel Discussion with Drs. Drewlo, Miranda, Smith and Taylor

6:15 p.m. - 6:45 p.m.

Question and Answer

6:45 p.m. - 8:00 p.m.

Welcome Reception
Join us for socializing, wine and light appetizers.

Signature Island

Thursday, March 16

7:00 a.m. - 6:00 p.m.

Registration

Bonnet Creek Foyer

8:00 a.m. - 10:00 a.m.

Welcome Address, President's Distinguished Lecture I, New Investigator Plenary

Floridian D - I

8:00 a.m. - 8:10 a.m.

Welcome Address
SRI President Yoel Sadovsky, MD

8:10 a.m. - 9:00 a.m.

President's Distinguished Lecture I
Eligible for 1.0 AMA PRA Category 1 Credits ™ / 1.0 Category I College Cognate Credits

Leveraging "Big Data" for Individualized Care
Suchi Saria, PhD
Assistant Professor, Department of Computational Sciences
Johns Hopkins University

9:00 a.m. - 10:00 a.m.

New Investigator Plenary Session
Moderators: Yoel Sadovsky, MD
  Sandra Davidge, PhD

9:00 a.m. - 9:15 a.m.

MiR-200b Mediates the Teratogenic Effect of Maternal Diabetes Leading to Neural Tube Defects by Suppressing Autophagy and Inducing Endoplasmic Reticulum Stress
Daoyin Dong, PhD

9:15 a.m. - 9:30 a.m.

SOX17 Governs the Indian Hedgehog to Promote Female Fertility via Uterine Epithelial-Stromal Interactions
Xiaoqiu Wang, PhD

9:30 a.m. - 9:45 a.m.

Cervical Gene Delivery of Human Beta-Defensin-3(HBD-3) Prevents Ascending Bacterial Infection in Pregnant Mice
Natalie Suff, PhD Student

9:45 a.m. - 10:00 a.m.

Maternal Lifestyle Impairs Embryonic Growth: A Prospective Periconception Cohort Study
Matthijs R. Van Dijk, MD

10:00 a.m. - 11:30 a.m.

Poster Session I

Bonnet Creek I - IX

12:00 p.m. - 1:30 p.m.

Past President's Lunch (By Invitation Only)

Brevard

12:00 p.m. - 1:30 p.m.

Special Symposia I
Systems Biology in Pregnancy Health and Research

Moderator: Mark Chance, PhD
Nathan Price, PhD

Floridian D - I

12:00 p.m. - 12:30 p.m.

Network Biology Tools for Translational Research
Mark Chance, PhD

12:30 p.m. - 1:00 p.m.

Systems Analysis of OMICS Data in Pregnancy Conditions
Nathan Price, PhD

1:00 p.m. - 1:30 p.m.

Genestation: A Powerful Platform for Integrating Diverse Types of OMICS Data to Understand Pregnancy and its Pathologies
Antonis Rokas, PhD

1:45 p.m. - 3:45 p.m.

Mini Symposia I

Various

The Influence of Circadian Rhythms on Reproductive Outcomes
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: Sarah K. England, PhD
Bonnet Creek X

 

1:45 p.m. - 2:15 p.m.

The Influence of Chronodisruption on Risk of Preterm Birth
Sarah K. England, PhD

2:15 p.m. - 2:45 p.m.

The Ability of Light to Suppress Contractions in Late-Term Pregnant Women; Mechanisms for Melatonin Action in the Human Uterus
Elizabeth B. Klerman, MD, PhD

2:45 p.m. - 3:15 p.m.

Circadian Rhythms in the Fetus
Claudia Torres-Farfan, PhD

3:15 p.m. - 3:45 p.m.

Estrogenic Modulation of Activity Rhythms in Development and Adulthood
Megan M. Mahoney, PhD

Fundamental and Translational Aspects of Extracellular Vesicles: Focus on the Female Reproductive System
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: Thomas E. Spencer, PhD

Bonnet Creek XI

1:45 p.m. - 2:15 p.m.

Extracellular Vesicles and Ovarian Function and Disease
Lane Christenson, PhD

2:15 p.m. - 2:45 p.m.

Extracellular Vesicles as Important Mediators of Uterine Function
Thomas Spencer, PhD

2:45 p.m. - 3:15 p.m.

Dialogue Between the Maternal Endometrium and the Embryo: Potential Impact on Onset Adult Disease
Felipe Villela, MD, PhD

3:15 p.m. - 3:45 p.m.

ExRNAs as Biomarkers for Placental Dysfunction
Louise C. Laurent, MD, PhD

Fetal Membrane Weakening and Rupture-Understanding PPROM in Four Dimensions
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: John Moore, MD

Floridian B

1:45 p.m. - 2:15 p.m.

Preterm Premature Rupture of Membranes - Clinical Perspectives
Brian Mercer, MD

2:15 p.m. - 2:45 p.m.

Novel Targets for Inhibition of Inflammation for the Prevention of PPROM
Martha Lappas, PhD

2:45 p.m. - 3:15 p.m.

Deformation and Rupture of Fetal Membranes - Microstructural Mechanisms Which May Account for Their Toughness or Brittleness
Edoardo Mazza, PhD

3:15 p.m. - 3:45 p.m.

Insight Gained From a Human In-Vitro Model System of Fetal Membrane Weakening
Deepak Kumar, MD

The -OMICs Revolution in Understanding of Uterine Leiomyomas, and the Future of Therapy
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: William H. Catherino, MD, PhD

Bonnet Creek XII

1:45 p.m. - 2:15 p.m.

The Genetics and Genomics of Leiomyomas
William H. Catherino, MD, PhD

2:15 p.m. - 2:45 p.m.

Developmental Epigenetics and Uterine Fibroids
Ayman Al-Hendy, MD, PhD

2:45 p.m. - 3:15 p.m.

Pathogenesis and Etiology of Uterine Fibroids: Opportunities for Research
James Segars, MD

3:15 p.m. - 3:45 p.m.

What is Effective Fibroid Treatment?
Elizabeth Stewart, MD

An Applied System Biology to Study the Endometrial Receptivity
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: Jose Antonio Horcajadas, PhD

Floridian A

1:45 p.m. - 2:15 p.m.

The Transcriptomics of the Endometrium: A 15 Year Data Experience
Jose Antonio Horcajadas, PhD

2:15 p.m. - 2:45 p.m.

The Proteomic Interactome of the Endometrial Receptivity
Francisco Dominguez, PhD

2:45 p.m. - 3:15 p.m.

A System Biology Approach to Understand the Endometrium's Physiology and the Endometrial Receptivity
Andres Salumets, PhD

3:15 p.m. - 3:45 p.m.

Endometrial Receptivity Tests: Advanced Molecular Tools to Study the Endometrial Receptivity
Sergio C. Oehninger, MD, PhD

Delineating Contributors to the Genesis and/or Treatment Resistance Properties of Gynecologic Cancers
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: Bo R. Rueda, PhD

Floridian C

1:45 p.m. - 2:15 p.m.

Unbiased Molecular Analysis of Progesterone Receptor Action in Cancer Identifies Novel Mechanisms and Processes
J. Julie Kim, PhD

2:15 p.m. - 2:45 p.m.

Clincopathologic Significance of Mismatch Repair Defects in Endometrial Cancer and Promise for Immune Checkpoint Blockade-Based Therapies
Paul Goodfellow, PhD

2:45 p.m. - 3:15 p.m.

Epithelial Cell Plasticity and the Origins of Ovarian Cancer
Barbara Vanderhyden, PhD

3:15 p.m. - 3:45 p.m.

Ovarian Cancer Stem Cells Display Resistance to PARP Inhibitor Treatment
Bo R. Rueda, PhD

3:45 p.m. - 4:00 p.m.

Coffee Break

Bonnet Creek I - IX

4:00 p.m. - 6:00 p.m.

Concurrent Oral Presentations I

Various

Clinical Perinatology I
Moderators:
Deepak Kumar
Jeff Reese, MD

Bonnet Creek X

4:00 p.m. - 4:15 p.m.

Non-Invasive Assessment of Fetal CMV Infection and Injury via Fetal Neuronal Exosomes: A Non-Human Primate Model
Laura Goetzl, Nune Darbinian, Nana Merabova, Kinari Patel, Alice F. Tarantal, Peter A. Barry

4:15 p.m. - 4:30 p.m.

The New Triple I Classification Scheme and Outcomes Among Term Infants
Christina A. Herrera, Julie Shakib, Erin A.S. Clark, Michael W. Varner, Bob Silver

4:30 p.m. - 4:45 p.m.

Network Analysis of Maternal Genes Implicated in Preterm-Birth
Maria Schmoll, Ravindu Gunatilake, Avinash Patil, Annabeth Barnard

4:45 p.m. - 5:00 p.m.

Futurebirth™ Prediction by 12w of Future Preterm Birth (PTB)<33w Using a Novel Test of Cell Free Plasma (cfp) RNA
Carl Weiner, Helen Zhou, Howard Cuckle, Argyro Syngelaki, Kypros Nicolaides, Yafeng Dong

5:00 p.m. - 5:15 p.m.

Altered Acylcarnitine Metabolism in the Placenta in Spontaneous Preterm Birth
Summer Elshenawy, Paschalis T. Doulias, Samuel Parry, Michael Bennett, Harry Ischiropolous, Rebecca A. Simmons

5:15 p.m. - 5:30 p.m.

PreImplantation Factor (PIF*) Prevents Fetal Loss by Modulating LPS Induced Inflammatory Response
Martin Mueller, Nicoletta Di Simone, Fiorella Di Nicuolo, Riccardo Marana, Roberta Castellani, Francesco Ria, Manuela Veglia, Giovanni Scambia, Daniel Surbek, Eytan Barnea

5:30 p.m. - 5:45 p.m.

Genetic Deficiency in IL-6 Modifies Sex-Related Differences in Neonatal Mouse Mortality in Response to Influenza Infection
Elizabeth A. Bonney, Jenna E. McQuesten, Kendall Krebs, Mercedes Rincon

5:45 p.m. - 6:00 p.m.

Healthy, Infection-Free Growth of Preterm Lambs Maintained with Ex-Vivo Uterine Environment (EVE) Therapy for One Week
Haruo Usuda, Shimpei Watanabe, Eleanor Woodward, Masatoshi Saito, Gabrielle C. Musk, Suhas G. Kallapur, Judith Rittenschober-Bohm, Hideyuki Ikeda, Shinichi Sato, Takushi Hanita, Tadashi Matsuda, John P. Newnham, Matthew W. Kemp

Endometriosis, Fibroids and Gynecology I
Moderators:
Robert N. Taylor, MD, PhD
Richard O. Burney, MD, MSc

Floridian B

4:00 p.m. - 4:15 p.m.

GATA6 Confers an Immunologic Phenotype in Endometriosis
Christia Angela M. Sison, Matthew T. Dyson, Serdar Bulun

4:15 p.m. - 4:30 p.m.

Role of the Wnt Pathway in Endometriosis
Maik Obendorf, Juliane Hundt, Eva Simon, Raif Lesche, Rene Wenzl, Lorenz Kuessel, Thomas M. Zollner

4:30 p.m. - 4:45 p.m.

Prostaglandin E2 Signaling, Estrogen-Dominance and Progesterone-Resistance in Endometriosis
Joe A. Arosh, JeHoon Lee, Kaylon L. Bruner-Tran, Kevin G. Osteen, Sakhila K. Banu

4:45 p.m. - 5:00 p.m.

Endometriosis Inherently Increases the Number of CD146/CD140b Double Positive Cells in the Eutopic Endometrium of Baboons with Induced Disease
Fatima Barragan, Michael R. Strug, Ren-Wei Su, Amanda Patterson, Asgerally Fazleabas

5:00 p.m. - 5:15 p.m.

P2X3 - A Highly Innovative Target for the Non-Hormonal Treatment of Endometriosis
A Davenport, N. Brauer, A. Rotgeri, A. Rottmann, M. Koch, T.M. Zollner, A. Steinmeyer, J. Nagel, F. Machet, A. Coelho, S. Boyce, L. Bone, M. Gemkow, N. Carty, M. Hermann, S. Hess, I. Neagoe, O.M. Fischer

5:15 p.m. - 5:30 p.m.

Progesterone and KLF11 Mediate Sexually Dimorphic Fibrotic Responses
Chandra C. Shenoy, Ye Zheng, Tiffanny L. Jones, Zaraq Khan, Gaurang S. Daftary

5:30 p.m. - 5:45 p.m.

RPLP1 is a Novel Target of miR-451a Whose Expression is Elevated in Endometriotic Lesion Tissue and Correlates with Endometriotic Lesion Tissue and Cell Proliferation
Zahraa Alali, Tommaso Falcone, Warren B. Nothnick

5:45 p.m. - 6:00 p.m.

Expression Quantitative Trait Loci (eQTL) Approaches for Understanding the Genetics of Endometriosis
Peter A.W. Rogers, Sarah J. Holdsworth-Carson, Jenny N. Fung, Eliza M. Colgrave, Premila Palva, Jane E. Girling, Grant W. Montgomery

Maternal Biology and Health
Moderators:
Kirk P. Conrad, MD
Dean Myers, PhD

Floridian C

4:00 p.m. - 4:15 p.m.

Fetal Microchimerism by Mode of Delivery in Healthy Term Gestations
Raj Shree, J.L. Nelson, Sami B. Kanaan, Alexandra Forsyth, Emma Cousin, Hilary S. Gamill

4:15 p.m. - 4:30 p.m.

Association Between the a2 Isoform of Vacuolar ATPase and Markers of Inflammation in Peripheral Blood Mononuclear Cells from Pregnant Women
Tomi T. Kanninen, Giovanni Sisti, Aswathi Jayaram, Steven R. Inglis, Ashwini Pandit, Steven S. Witkin

4:30 p.m. - 4:45 p.m.

Unique Innate Lymphoid Cells Revealed by Machine Learning/Dimensionality Reduction in Human Decidua
Jessica Vazquez, Yan Li, Aleksandar K. Stanic

4:45 p.m. - 5:00 p.m.

Placental Growth Factor (Pigf) Blunts the Vascualr Response to Angiotensin II: A Novel Mechanism for Vascular Regulation During Pregnancy
Jimmy Espinoza, Ancizar Betancourt, Karin Fox, Alireza Abdollah Shmshirsaz, Chandra Yallampalli

5:00 p.m. - 5:15 p.m.

Leptin Receptors During the Ovarian Cycle and Pregnancy: Angiogenesis in Uterine Artery Endothelial Cells
Vladmir E. Vargas, Rosalina Villalon Landeros, Gladys E. Lopez, Jing Zhen, Ronald R. Magness

5:15 p.m. - 5:30 p.m.

Venoarterial Signaling (VAS) Modulates Shear Stress-Induced Gestational Uterine Artery Expansive Remodeling
Nga Ling Ko, Maurizio Mandala, Liam V. John, Adama Aja, George J. Osol

5:30 p.m. - 5:45 p.m.

Pregnancy-Specific Estrogen Receptor-Mediated Upregulation of Endothelial AT, Receptor
Jay Mishra, Kathirvel Gopalakrishnan, Gary Hankins, Sathish Kumar

5:45 p.m. - 6:00 p.m.

The Association Between the History of Hypertensive Disorders of Pregnancy, Obesity and Hypertension in Later Life by Age Group: A Cross-Sectional Analysis
Maiko Wagata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Hirohito Metocki, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Shinichi Kurlyama, Atshush Hozawa, Junichi Sugawara

Parturition I
Moderators:
Terry Morgan, MD, PhD
Roger Smith, AM, MBBS, FRACP, PhD

Bonnet Creek XII

4:00 p.m. - 4:15 p.m.

The Host Defence Peptide Cathelicidin Mediates Inflammatory Preterm Birth
Tina Baker, Heather MacPherson, Kirsten Wilson, Sara Rinaldi, Lorraine Frew, Adrian Thomson, Carmel Moran, Julia Dorin, Donald Davidson, Sarah J. Stock

4:15 p.m. - 4:30 p.m.

Protease Amplification of the Inflammatory Response Induced by L. Iners: Implications for Racial Disparities in Preterm Birth
Sheikh M.K. Alam, William H. Nugent, Sonya L. Washington, Kimberly K. Jefferson, Jerome F. Strauss III, Scott W. Walsh

4:30 p.m. - 4:45 p.m.

Vaginal Dysbiosis Increases Risk of Preterm Membrane Rupture, Funisitis and Neonatal Sepsis
Richard G. Brown, Yun S. Lee, Anne Smith, Lyndsay Kindinger, Julian R. Marchesi, Phillip R. Bennettt, David A. MacIntyre

4:45 p.m. - 5:00 p.m.

hCG Suppresses IP-10 in Human Decidua Through Histone Methylation
Michelle Silasi, Yang Yang-Hartwich, Gil Mor, Rosanna Ramhorst, Esteban Grasso

5:00 p.m. - 5:15 p.m.

Relationship Between Yeast, Vaginal Microbiota Composition and Pregnancy Outcomes
Holly Lewis, Pamela Pruski, Lindsay Kindinger, Yun Lee, Phillip Bennett, Zoltan Takats, David A. MacIntyre

5:15 p.m. - 5:30 p.m.

Nur77, a Novel Player in Perinatal Neuroinflammation Associated with Preterm Labor in a Murine Model (Mus Musculus)
Sarah Estrada, ANdew Thagard, Irina Burd, Peter Napolitano, Nicholas Ieronimakis

5:30 p.m. - 5:45 p.m.

Effects of Receptor for Advanced Glycation End-Products (RAGE) on Inflammation Induced Preterm Birth and Neonatal Viability in a Genetically Engineered Mouse Model
Bethany T. Stetson, Brian A. Kellert, Hanaa Motawea, Megan Locke, Guomao Zhao, Antonette T. Dulay, Catalin S. Buhimschi, Irina A. Buhimschi

5:45 p.m. - 6:00 p.m.

T-Cell Activation-Induced Preterm Labor Involves Unique Innate and Adaptive Immune Responses That Differ from Those Observed in Inflammation- and Progesterone Withdrawal-Induced Preterm Labor
Marcia Arenas-Hernandez, Roberto Romero, Tara N. Mial, Felipe Vadillo-Ortega, Sonia S. Hassan, Nardhy Gomez-Lopez

Preeclampsia I
Moderators:
Justyna Dopierala, PhD
Norman Gant, MD

Bonnet Creek XI

4:00 p.m. - 4:15 p.m.

Targeted Nanoparticle Delivery of Short Interfering RNAs to Treat Preeclampsia
Natalie J. Hannan, Scott Pattison, Sally Beard, Natalie K. Binder, Jennifer MacDiarmid, Himanshu Brahmbhatt, Tu'uhevaha J. Kaitu'u-Lino, Stephen Tong

4:15 p.m. - 4:30 p.m.

Hydrogen Sulphide Ameliorates Preeclampsia-Like Phenotype Induced by Elevated sFlt-1 in Placenta Growth Deficiency
Shakil Ahmad, Keqing Wang, Peter Hewett, Asif Ahmed

4:30 p.m. - 4:45 p.m.

A Novel Conjugated Linoleic Acid Therapy for Preeclampsia Shows Protective Effects on Human Endothelial Cell Function In Vitro
Danielle M. Berdahl, Dinesh M. Shah, Ian M. Bird, Derek S. Boeldt

4:45 p.m. - 5:00 p.m.

Fetal Asymmetric Dimethylarginine Regulates Maternal Haemodynamics
Aikaterini Georgopoulou, James Leiper, Mark R. Johnson

5:00 p.m. - 5:15 p.m.

Molecular Evidence for Abnormal Differentiation of Invasive Trophoblast in Preeclampsia
Anna Natenzon, Sonia DaSilva-Arnold, Stacy Zamudio, Abdulla Al-Khan, Nicholas P. Illsley

5:15 p.m. - 5:30 p.m.

Role of Estrogen and Its Metabolites in Uterine Artery Endothelial Cells Migration from a Model of Unilateral Pregnant Sheep
Rosalina Villalon-Landeros, Chi Zhou, Jing Zheng, Ronald R. Magness

5:30 p.m. - 5:45 p.m.

A Randomised Controlled Trial and Cost-Effectiveness Analysis of Low Dose Aspirin with an Early Screen Test for Preeclampsia in Low Risk Women
F. Mone, C. Mulcahy, P. McParland, J. O'Mahony, E. Tyrell, F. Breathnach, C. Normand, F. Cody, J. Morrison, S. Daly, J. Higgins, A. Cotter, E. Tully, P. Dicker, Z. Alfirevic, F. Malone, F.M. McAuliffe

5:45 p.m. - 6:00 p.m.

Three Protein-Truncating Mutations That May Contribute to Developing Preeclampsia
H.S. Gammill, R. Chettier, A. Brewer, J.M. Roberts, R. Shree, E. Tsigas, K. Ward

Reproductive Biology I
Moderators:
Zaher Merhi, MD
Felice Petraglia, MD

Floridian A

4:00 p.m. - 4:15 p.m.

Maternal MiR-30d Deficiency is Associated with Defects in Endometrial Receptivity, Embryonic Implantation and Fetal Development
Nuria Balaguer, Inmaculada Moreno, Maria Herrero, Marta Gonzalez-Montfort, Carlos Simon, Felipe Vilella

4:15 p.m. - 4:30 p.m.

Double Conditional Knockout of SMAD2 and SMAD3 Results in Endometrial Dysfunction, Infertility, and Uterine Cancer
Maya Kriseman, Diana Monsivais, Julio Agno, Ramya Masand, William Gibbons, Martin Matzuk

4:30 p.m. - 4:45 p.m.

Non-Classical Progesterone Reeptor (PGRMC1) and SERPINE1 mRNA Binding Protein (SERBP1) Interaction Influences the Human Decidualization Process
Stefania Salsano, Alicia Quinonero, Silvia Perez, Carlos Simon, Francisco Dominguez

4:45 p.m. - 5:00 p.m.

Hypoxia Inducible (HIF) in the Endometrium: A Potential Therapeutic Target for Heavy Menstrual Bleeding (HMB)
Jacqueline A. Maybin, Alison Murray, Nik Hirani, Philippa T.K. Saunders, Peter Carmeliet, Hilary O.D. Critchley

5:00 p.m. - 5:15 p.m.

Remodeling of Deicdual Immune Landscape Across Murine Pregnancy
Yan Li, Jessica Vazquez, Melina Chavarria, Aleksandar Stanic-Kostic

5:15 p.m. - 5:30 p.m.

In Vitro Model of Bacterial Colonization for the Study of the Effect of the Endometrial Microbiota on the Reproductive Function
Inmaculada Moreno, Iolanda Garcia-Grau, Angela Silva, Felipe Vilella, Diana Valbuena, Daniel Ramon, Carlos Simon

5:30 p.m. - 5:45 p.m.

Perivascular Expression of Vascular Adhesion Protein 1 (VAP-1) in the Endometrium Regulates Uterine Natural Killer (uNK) Cell Recruitment and Spiral Artery Remodeling in Pregnancy
Seley Gharanei, Ruban P. Durairaj, Tianrong Jin, Kuo-Kang Liu, Christopher Weston, Marko Salmi, Pia Rantakari, Sirpa Jalkanen, Jan J. Brosens, Bee K. Tan

5:45 p.m. - 6:00 p.m.

Mice Lacking Functional TRPV2 Show Intrauterine Growth Restriction
Katrien De Clercq, Charlotte Van den Eynde, Silvia Pinto, Voets Thomas, Vriends Joris

6:15 p.m. - 7:45 p.m.

Connection Corners
New, Early and Mid-Career Investigators are invited to come meet and 'connect' with Senior Investigators about jobs, career advice or just some friendly banter. Drinks and light appetizers provided.

Bonnet Creek Pavilion

2017 Table Topics

1. From Trainee to PI

2. Your First SRI Meeting

3. From the Bench to the Bedside

4. Finding a Good Mentor - Mentor in the Cloud

5. Networking Tips

6. Negotiating: Getting What You Need to Succeed

7. Clinical Grantsmanship

8. Basic Science Grantsmanship

9. Publishing Tips and Tricks

10. Physician-Scientist: Is There Time to Sleep?

11. A Healthy Work-Life Balance

12. Careers Outside of Academia

Friday, March 17

7:00 a.m. - 6:30 p.m.

Registration

Bonnet Creek Foyer

7:15 a.m. - 8:00 a.m.

SRI Business Meeting (Members Only)

Floridian D - I

8:00 a.m. - 9:00 a.m.

President's Distinguished Lecture II
Eligible for 1.0 AMA PRA Category 1 Credits ™ / 1.0 Category I College Cognate Credits

Floridian D - I

Molecular Stethoscope in Pregnancy
Stephen Quake, PhD
Lee Otterson Professor in the School of Engineering and Professor of Bioengineering, of Applied Physics, and, By Courtesy, of Physics
Stanford University

9:15 a.m. - 10:45 a.m.

Concurrent Oral Presentations II

Various

Developmental Programming I
Moderators:
John Challis, PhD, FRCOG, FRSC
Alina Maloyan, PhD

Floridian C

9:15 a.m. - 9:30 a.m.

The Mitochondria-Targeted Antioxidant MitoQ Prevents the Programming of Cardiovascular Dysfunction by Developmental Hypoxia in Sheep
K.J. Botting, K.L. Skeffington, Y. Niu, B.J. Allison, K.L. Brain, N. Itani, C. Beck, A. Logan, M.P. Murphy, D.A. Giussani

9:30 a.m. - 9:45 a.m.

Apidonectin Supplementation During Late Pregnancy Normalises Offspring Cardiac Hypertrophic Gene Expression in a Mouse Model of Maternal Obesity
Owen R. Vaughan, Frederick J. Rosario, Megan Gossling, Theresa Powell, Thomas Jansson

9:45 a.m. - 10:00 a.m.

Chronic Fetal Hypoxaemia & Maternal Antioxidants: Identifying Mechanisms and Treatments to Improve Postnatal Lung Structure & Function in Growth Restricted Offspring
E.V. McGillick, S. Orgeig, B.J. Allison, K.L. Brain, Y. Niu, N. Itani, K.L. Skeffington, C. Beck, K.J. Botting, D.A. Giussani, J.L. Morrison

10:00 a.m. - 10:15 a.m.

Effects of Prenatal Hypoxia on Fetal Cardiomyocyte Proliferation
Laura M. Reyes, Amin Shah, Anita Quon, Sandra T. Davidge

10:15 a.m. - 10:30 a.m.

Maternal Obesity (MO) Compromises Term Fetal Offspring (F1) Heart Mitochondrial Bioenergetic Profile
Qiurong Wang, Chaoqun Zhu, John F. Odhiambo, Guadalupe L. Rodriguez Gonzalez, Peter W. Nathanielsz, Stephen P. Ford, Jun Ren, Wei Guo

Fetus I
Moderators:
Leslie Myatt, PhD, FRCOG
Emily Su, MD

Bonnet Creek I

9:15 a.m. - 9:30 a.m.

Oxygen and Glucose Supplementation Reduces Stress in Growth Restricted Sheep Fetuses
Leticia Camacho, Melissa Davis, Nathan Steffens, Amy Kelly, Sean Limesand

9:30 a.m. - 9:45 a.m.

Late-Onset Chronic Hypoxia Abolishes Adrenomedullary but Sensitises Adrenocortical Plasma Respones to Acute Stress in Fetal Sheep
N. Itani, C.S. Shaw, B.J. Allison K.L. Brain, Y. Niu, C.C. Lees, D.A. Giussani

9:45 a.m. - 10:00 a.m.

Effect of Maternal Antioxidant MitoQ Treatment in a Rat Model of Intrauterine Growth Restriction (IUGR)
Esha Ganguly, Jude S. Morton, Christy L. Cooke, Sandra T. Davidge

10:00 a.m. - 10:15 a.m.

Maternal Antioxidant Treatment Markedly Sensitises Antioxidant Gene Expression in Peri-Renal Fat of Fetal Offspring of Hypoxic Pregnancy
A Martin, B.J. Allison, K.L. Brain, C. Ducsay, D. Myers, D.A. Giussani

10:15 a.m. - 10:30 a.m.

Elevated Hepatic Gluconeogenesis by H19-Mediated Epigenetic Regulation Underlies Altered Metabolism in Offspring Prenatally Exposed to Metformin
Jie Deng, Tingting Geng, Yunyuan Shen, Liyong Zhu, Ya Liu, Hugh S. Taylor, Michael Paidas, Yingqun Huang

10:30 a.m. - 10:45 a.m.

In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanized Mouse Mode and Its Progress Can Be Monitored Using MRI Techniques
Panicos Shangaris, Stavros Loukogeorgakis, Laurence Jackson, Wei Wang, Mike Blundell, Shanrun Liu, Sindhu Subramaniam, Simon Eaton, Mike Antoniou, Daniel Stuckey, Manfred Schmidt, Adrian Thrasher, Thomas Ryan, Paolo De Coppi, Anna David

Endometriosis, Fibroids and Gynecology II
Moderators:
Sarah L. Berga, MD
Hiroshi Ishikawa, MD, PhD

Floridian B

9:15 a.m. - 9:30 a.m.

Mechanisms of Dysregulated RANKL Gene Expression in Uterine Leiomyoma: Involvement of Epigenetic Modification and MED12 Gene Mutations
Shimeng Liu, Ping Yin, Stacy A. Kujawa, Serdar E. Bulun

9:30 a.m. - 9:45 a.m.

Ulipristal Treatment Highlights the Link of MED12 and Fibrosis Regulation in Leiomyomas
Minnie Malik, Joy Britten, Lynnette Nieman, Matthew Wilkerson, Xijun Zhang, Jeris Cox, William Catherino

9:45 a.m. - 10:00 a.m.

Feedback Regulation Between TGF-?3 and miR-29c in Leiomyoma
Tasi-Der Chuang, Omid Khorram

10:00 a.m. - 10:15 a.m.

Inflammatory and Immunological Processes are Strongly Dysregulated in Uterine Fibroids Compared to Normal Myometrium and are Shown to Offer Novel as Well as Effective Treatment Options for Uterine Fibroids
Jorg Muller, Anette Sommer, Andrea Wagenfeld, Markus Koch, Thomas Zollner

10:15 a.m. - 10:30 a.m.

Rank-Fc Inhibits Growth of Leiomyoma Cells and Decreases Tumor Growth in Vivo
Deborah E. Ikhena, Shimeng Liu, Stacy Kujawa, Serdar E. Bulun

10:30 a.m. - 10:45 a.m.

Expression of Tumor Suppressor PCDH10 in Uterine Leiomyomas and Leiomyomasarcomas
Joie Z. Guner, Gyoung E. Kim, Meaghan A. Delaney, Triparna Ghosh-Choudhury, Cecilia Valdes, William Gibbons, Matthew L. Anderson

Parturition II
Moderators:
K. Joseph Hurt, MD, PhD
Joy Vink, MD

Bonnet Creek XII

9:15 a.m. - 9:30 a.m.

Human Labour: A Joint Venture of PRA and Era
Lubna Nadeem, Hedy Romero, Oksana Shynlova, Sam Mesiano, Stephen Lye

9:30 a.m. - 9:45 a.m.

Thrombin-Induced Decidual C SF2 Induces Abruption-Related Preterm Birth by Weakening Fetal Membranes
Rachel Sinkey, Sefa Arlier, Robert Moore, Frederick Schatz, Nihan Smerci, Chinedu Nwabuobi, Kellie Larsen, Ozlem Guzeloglu-Kayisli, Deepak Kumar, John Moore, Umit Kayisli, Charles Lockwood

9:45 a.m. - 10:00 a.m.

Uterine Preconditioning Regulates Gestational Length
Judith Ingles, Jennifer Condon, Pancharatnam Jeyasuria

10:00 a.m. - 10:15 a.m.

IL-1 Signaling is Critical for Neutrophil Recruitment and Activation in a Rhesus Macaque Model of Intrauterine Inflammation
Pietro Presicce, Paranthaman Senthamaraikannan, Courtney Jackson, Cesar M. Rueda, Lisa A. Miller, Claire A. Chougnet, Alan H. Jobe, Suhas G. Kallapur

10:15 a.m. - 10:30 a.m.

Platelet Activating Factor (PAF) Induces Preterm Birth in Mice Through TLR4-Dependant Induction of Pro-Inflammatory Cytokines
Hanan H. Wahid, Lachlan M. Moldenhauer, Kenner C. Rice, Mark R. Hutchison, Sarah A. Robertson

10:30 a.m. - 10:45 a.m.

Oxidative Stress Induced p38MAPK Activation in Human Amnion Epithelial Cells are Independent of ASK1-Signalosome
L. Richardson, C.L. Dixon, R. Menon

Placenta I
Moderators:
Tania L. Gonzalez, PhD
Loren P. Thompson, PhD

Bonnet Creek XI

9:15 a.m. - 9:30 a.m.

The Detection of Placental Oxygenation by Photoacoustic Imaging and Ultrasound
Liliya M. Yamaleyeva, Yao Sun, Tiffaney Bledsoe, K. Bridget Brosnihan

9:30 a.m. - 9:45 a.m.

The Human Placental Proteome Secreted into the Maternal and Fetal Circulations
Trond M. Michelsen, Tore Henriksen, Theresa L. Powell, Thomas Jansson

9:45 a.m. - 10:00 a.m.

The Use of Circulating MicroRNAs to Predict Placental Dysfunction in Women at Risk of Stillbirth
Bernadette C. Baker, Sylvia Lui, Alexandar E.P. Heazell, Karen Forbes, Rebecca L. Jones

10:00 a.m. - 10:15 a.m.

Insertion of Human Corticotrpin-Releasing Hormone and Retroviral Regulatory Element THE1B into the Mouse Genome Delays Timing
Catlin E. Dunn-Fletcher, Lisa M. Muglia, Elizabeth L. Huffman, Louis J. Muglia

10:15 a.m. - 10:30 a.m.

Oxygen-Dependent JMJD6 Regulation of Fibronectin Synthesis and Assembly in the Human Placenta
Sruthi Alahari, Isabella Caniggia

10:30 a.m. - 10:45 a.m.

A Distinct Signature of ATP-Binding Cassete Transporter Expression in the Preterm Human Placenta with Chorioamnionitis
Guinever E. IMperio, Enrrico Bloise, Mohsen Javan, Phetcharawan Lye, Andrea Constantinof, Caroline Dunk, Fernando M. Reis, Stephen J. Lye, William Gibb, Tania M. Ortega-Carvalho, Stephen G. Matthews

Reproductive Endocrinology and Infertility I
Moderators:
Lisa Halvorson, MD
Satu Kuokkanen, MD, PhD

Floridian A

9:15 a.m. - 9:30 a.m.

Cross-Sex Testosterone Therapy is Not Sufficient for Bone Development in Female Mice: Implications for Treating Transgender Youth
Laura G. Goetz, Ramanaiah Mamillapalli, Maureen J. Devlin, Masoumeh Majidi-Zolbin, Hugh S. Taylor

9:30 a.m. - 9:45 a.m.

Elevated Androgen Levels Impair Connexin43 Function Leading to Decreased EDHF-Mediated Relaxation and Hypertension in Adult Female Rats
Amar More, Jay Mishra, Sathish Kumar

9:45 a.m. - 10:00 a.m.

Steroidogenic Factor 1 (Nr5a1) is Necessary for Sertoli Cell Differentiation Post Sex Determination
Chandra S. Miryala, Prashanth Anamthathmakula, Jennifer Ondon, Revecca Moreci, Jeyasuria Pancharatnam

10:00 a.m. - 10:15 a.m.

Effects of Oxytocin on Atrophic Rat Vagina
Bernhard Lindenthal, Peter uhn, Ulrike Fuhrmann, Ildiko Terebesi, Ralf Lsche, Qiong Lin, Reinhard Nubbemeyer, Thomas M. Zollner, Christina Bartnitzek

10:15 a.m. - 10:30 a.m.

Obesity Prevents Protective Down-Regulation of Mitogenic Insulin Receptor A in Uteri of Diet-Induced Obese Mice
Clare Flannery, Caitlin Radford, Farrah Saleh, Gina Choe, Jung Dae Kim, Sabrina Diano, Hugh Taylor

10:30 a.m. - 10:45 a.m.

Altered Early Luteal Phase miRNA 483-3p Expression in Women with PCOS
Iris Eisenberg-Loebl, Debra Goldman-Wohl, Caryn Greenfield, Ronit Haimov-Kochman, Simcha Yagel, Tal Imbar

10:45 a.m. - 12:15 p.m.

Poster Session II

Bonnet Creek I - IX

12:30 p.m. - 2:00 p.m.

Special Symposia II
Precision Medicine and Women's Health
Moderator: Diana Bianchi, MD

Floridian D - I

12:30 p.m. - 1:00 p.m.

Precision Medicine and Women's Health
Linda Giudice, MD, PhD, MSc

1:00 p.m. - 1:30 p.m.

Fetal Precision Medicine
Diana Bianchi, MD

1:30 p.m. - 2:00 p.m.

Precision Medicine for Gynecologic Cancers
Gordon Mills, MD

12:30 p.m. - 2:00 p.m.

Pfizer-SRI President's Presenter's Awards Lunch

Orange

2:15 p.m. - 3:45 p.m.

Concurrent Oral Presentations III

Various

Clinical Perinatology II
Moderators:
Levent Mutlu, MD
Marc Spaanderman, MD, PhD

Bonnet Creek X

2:15 p.m. - 2:30 p.m.

Differential Increases in First Trimester Maternal Weight (MW) by Maternal Age Over the Past Decade in 2.6 Million Pregnancies: Opportunity to Target Teenagers for Obesity Prevention
Shara M. Evans, David A. Krantz, Terrance W. Hallahan, Mark I. Evans

2:30 p.m. - 2:45 p.m.

Apidonectin Prevents Obesity and Hepatic Steatosis in Mouse Offspring Born to Obese Dams
Megan Gossling, Frederick Rosario, Stephanie Wesolowski, Thomas Jansson, Theresa Powell

2:45 p.m. - 3:00 p.m.

A Randomized Controlled Trial of an M-Health Behavioural Lifestyle Intervention to Prevent Gestational Diabetes in Overweight and Obese Pregnancy: PEARS
Maria A. Kennelly, Kate M. Ainscough, Elizabeth J. O'Sullivan, Karen L. Lindsay, Fionnuala M. McAuliffe

3:00 p.m. - 3:15 p.m.

Mild Intraventricular Hemorrhage is Not Associated with Low Bayley Scores at Age 2
Emilie Vander Haar, Adina Goldberger, Cynthia Gyamfi-Bannerman

3:15 p.m. - 3:30 p.m.

Adrenomedullin is a New Modulator of Lipolysis in Human Adipocytes
Yuanlin Dong, Chandra Yallampalli

3:30 p.m. - 3:45 p.m.

The Impact of Altered IL-1 Signaling on Metabolic Dysfunction During Pregnancy
Jasmine Plows, Thashma Ganapathy, Phililp Baker, Mark Vickers, Joanna Stanley, Clare Reynolds

Epidemiology, Population Health and Global Health: Focus on ZIKA
Moderators:
Irina Burd, MD, PhD
Indira U. Mysorekar, PhD

Bonnet Creek XII

2:15 p.m. - 2:30 p.m.

Short Interpregnancy Interval After Pregnancy Loss is Associated with Decreased Risk of Subsequent Miscarriage in a Prospective Cohort
Alexandra C. Sundermann, Katherine E. Hartmann, Sarah H. Jones, Eric S. Torstenson, Digna R. Velez Edwards

2:30 p.m. - 2:45 p.m.

Evaluating the Clinical Burden of Preeclampsia (PEC) on a Tertiary Care Hospital in Harare, Zimbabwe
Lydia L. Shook, Muchabayiwa F. Gidiri, Kara M. Rood, Irina A. Buhimschi

2:45 p.m. - 3:00 p.m.

Zika Virus Infects Human Endometrial Stromal Cells
Paola Panina-Bordignon, Isabel Pagani, Silvia Ghezzi, Adele Ulisse, Alicia Rubio, Elisabetta Garavaglia, Giuseppe Ippolito, Guido Poli, Elisa Vicenzi

3:00 p.m. - 3:15 p.m.

Zika Virus Infection Damages the Testes in Mice
Jacques Halabi, Prabagaran Esakky, Suzanne Scheaffer, Andrea Drury, Michael S. Diamond, Kelle H. Moley

3:15 p.m. - 3:30 p.m.

Hypermesis Gravidarum: Risk of Recurrence in Subsequent Pregnancies
Michael J. Fassett, Morgan R. Peltier, Darios Getahun

3:30 p.m. - 3:45 p.m.

Zika Infection in Pregnant Rhesus Macaques Results in Placental Injury and Altered Brain Development Independent of Microcephaly
Peta L. Grigsby, Victoria H. Roberts, Alec J. Hirsch, Matthias C. Schabel, Chris D. Kroenke, Jamie O. Lo, Xiaojie Wang, Zheng Liu, Jessica Smith, Nicole Haese, Meredith Kelleher, Rebecca Broeckel, Craig N. Kreklywich, Christopher J. Parkins, Patricia Smith, Victor DeFillppis, William Messer, Jay A. Nelson, Jon D. Hennebold, Marjorie Grafe, Lois Colgin, Anne Lewis, Rhonda MacAllister, Terry K. Morgan, Antonio E. Frias, Daniel N. Streblow

Gynecologic Oncology
Moderators:
Matthew L. Anderson, MD, PhD
Stefan M. Gysler, MD, MHS

Floridian B

2:15 p.m. - 2:30 p.m.

The Impact of the Cholesterol Metabolite 27-Hydroxycholesterol on Endometrial Proliferation
Douglas A. Gibson, Frances Collins, Arantza Esnal, Alistair R.W. Williams, Philippa T.K. Saunders

2:30 p.m. - 2:45 p.m.

SYD985 Shows Antitumor Activity in Uterine and Ovarian Cardinosarcoma with HER2/Neu Expression
Gulden Menderes, Elena Bonazzoli, Jonathan D. Black, Stefania Bellone, Francesca Pattinelli, Alice Masserdetti, Luca Zammataro, Gary Altwerger, Natalia Buza, Pei Hui, Serena Wong, Elena Ratner, Babak Litkouhi, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Peter Goedings, Patrick Beusker, Miranda van der Lee Marco, Timmers Wim Dokter, Alessandro D. Santin

2:45 p.m. - 3:00 p.m.

Serum MicroRNA Sequencing for Early Diagnosis of Invasive Ovarian Cancer
Kevin M. Elias, Wojciech F. Fendler, Konrad Stawiski, Allison Vitonis, Ross S. Berkowitz, Daniel W. Cramer, Dipanjan Chowdhury

3:00 p.m. - 3:15 p.m.

Exosomal Content in the Plasma of Patients with Ovarian Cancer Reflect Tumor State and Induce the Epithelial to Mesenchymal Transition in Target Cells
Shayna Sharma, Kathin Scholz-Romero, Richard Kline, Katrina Wade, Jacob Estes, Carlos Palma, Dominic Guanzon, Andrew Lai, John Hooper, Gregory E. Rice, Carlos Salomon

3:15 p.m. - 3:30 p.m.

Targeting Integrin αV/Β1 Receptor Manifests Intriguing Anti-Tumor Effects in Sensitive and Chemoresistant Ovarian Cancer Cells: Potential Therapeutic Target
Ghassan M. Saed, Nicole M. Fletcher, Ira Memaj, Mohammed G. Saed, Michael P. Diamond, Robert T. Morris

3:30 p.m. - 3:45 p.m.

FDG-PET/CT Kinetic Modeling Provides Detailed Information of Glucose Metabolism in Ovarian Cancer
Xiaohua Yang, Kuan-Hao Su, Jung-Wen Kuo, Mustafa Tunc, Stefanie Avril, Analisa DiFeo, Raymond F. Muzic Jr., Norbert Avril

Endometriosis, Fibroids and Gynecology III
Moderators:
Micah J. Hill, DO
Joop S.E. Laven, MD, PhD

Floridian C

2:15 p.m. - 2:30 p.m.

ATG4D Silencing Abrogates Autophagy and Induces a Fibroid-Like Transformation in Normal Human Myometrium Cells
Abdeljabar El Andaloussi, Nahed Ismail, Ayman Al-Hendy

2:30 p.m. - 2:45 p.m.

Can Preimplantation Genetic Screening (PGS) Be Applied to Previously Untested Cryopreserved Blastocysts?
Jessica Rubin, Alfred Wun, Cecilia Valdes, Randall Dunn

2:45 p.m. - 3:00 p.m.

The Impact of Excisional Treatment for Cervical Intraepithelial Neoplasia on the Vaginal Microbiota
Anita Mitra, David MacIntyre, Jonathan Lai, Yun Lee, Ann Smith, Julian Marchesi, Deirdre Lyons, Phillip Bennett, Maria Kyrgiou

3:00 p.m. - 3:15 p.m.

Progestin-Only Contraceptives Induce Decidualization by Enhancing ZBTB16 Expression: Implications for Abnormal Uterine Bleeding
Sefa Arlier, Ozlem Guzeloglu-Kayisli, Nihan Semerci, Kellie Larsen, Unit Kayisli, Frederick Schatz, Charles Lockwood

3:15 p.m. - 3:30 p.m.

A Calcium Channel Blocker Used to Treat Hypertension Alters Contractility of the Uterosacral Ligament: Implications for Pelvic Organ Prolapse
Marsha K. Guess, Joshua Johnson, Ritsuko Iwanaga, Kathleen A. Connell

3:30 p.m. - 3:45 p.m.

LGR5 is Expressed by Human Endometrial Epithelial Cells and Regulated by Progesterone
Nicola Tempest, Dharani Hapangama

Preeclampsia II
Moderators:
Chahinda Ghossein-Doha, MD
Carlos Salomon, MSc, PhD

Bonnet Creek XI

2:15 p.m. - 2:30 p.m.

VEGF Simulates Macrophage Recruitment and M2-Polarization in the Decidua: Potential Relevance to the Pathogenesis of Preeclampsia
Karen C. Wheeler, Manoj Jena, Bhola S. Pradhan, Bo Pei, Neha Nayak, Subhendu Das, Sabita Dhal, Kang Chen, Nihar R. Nayak

2:30 p.m. - 2:45 p.m.

Syncytiotrophoblast Extracellular Vesicles Alter Angiotensin-II Induced Vasoconstriction in Mouse Uterine Arteries
Floor Spaans, Jude S. Morton, Dionne S. Tannetta, Ian L. Sargent, Sandra T. Davidge

2:45 p.m. - 3:00 p.m.

Severe Preeclampsia is Associated with Resistance to Decidualization
Tamara Garrido-Gomez, Francisco Dominguez, Alicia Quinonero, Patricia Diaz-Gimeno, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Pablo Padilla, Olga Genbacev, Alfredo Perales, Susan J. Fisher, Carlos Simon

3:00 p.m. - 3:15 p.m.

Placental Extracellular Vesicles Can Sequester VEGF to Induce Endothelial Cell Activation: Relevance for Preeclampsia
Mancy Tong, Qi Chen, Jo L. James, Peter R. Stone, Larry W. Chamley

3:15 p.m. - 3:30 p.m.

Evidence for Partial Overlap of Molecular Etiology Between Preeclampsia and Decidualization Disorders
Maria B. Rabaglino, Emiel D. Post Uiterweer, Kirk P. Conrad

3:30 p.m. - 3:45 p.m.

High Resoluation Flow Cytometry Reveals Abnormal Distribution of Placental Extracellular Vesicles in Murine Placental Insufficiency Model
Nicole Marek, Mayu Morita, Pam Canaday, Terry K. Morgan

Reproductive Biology II
Moderators:
Linda C. Giudice, MD, PhD, MSc
Terrence D. Lewis, MD, PhD

Floridian A

2:15 p.m. - 2:30 p.m.

Granulocyte-Colony Stimulating Factor Reverses Detrimental Effects of High-Fat Diet on Ovarian Reserve
Delaney C. Swindle, Alex J. Polotsky, Malgorzata E. Skaznik-Wikiel

2:30 p.m. - 2:45 p.m.

High-Fat Diet and Aging Affect Ovarian RAGE Gene Expression
Erkan Buyuk, Maureen Charron, Kimberley Thornton, Obehi Asemota, Zaher Merhi

2:45 p.m. - 3:00 p.m.

AKAP13-Deficient Oocytes Show Signs of Precocious Exit from Prophase I Arrest
Carter M. Owen, Ophelia Yin, Sinnie Ng, Pola Olczak, Janice P. Evans, James H. Segars

3:00 p.m. - 3:15 p.m.

Maternally Expressed NLRP2 Links the Subcortical maternal Complex (SCMC) to Fertility, Embryogenesis and Epigenetic Reprogramming
Sangeetha Mahadevan, Varsha Sathappan, Budi Utama, Isabel Lorenzo, Khalied Kaskar, Ignatia Van den Veyver

3:15 p.m. - 3:30 p.m.

DMPS (Dimercapto-1-Propanesulfonic Acid), a Heavy Metal Chelator, Induces Oocyte Deterioration
Sarah R. Aldhaheri, Roohi Jeelani, Mili Thakur, Marisa Hildebrandt, Farnoosh Qadri, Husam M. Abu-Soud

3:30 p.m. - 3:45 p.m.

Med12is Critical in Reproductive Tract Development
Xinye Wang, Priya Mittal, Aleksandar Rajkovic

4:00 p.m. - 6:00 p.m.

Mini Symposia II

 

Mining Big Data to Reveal Biomarkers and Pathophysiology of Preterm Birth
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: Sam Mesiano, PhD

4:00 p.m. – 4:30 p.m.

Maternal Peripheral Blood Leukocytes as Biomarkers of Preterm Birth
Oksana Shynlova, PhD

4:30 p.m. – 5:00 p.m.

Multi-Omic Data Integration and Interrogation to Discover Network Signatures of Preterm Birth
Doug Brubaker, PhD

5:00 p.m. – 5:30 p.m.

In Richness and In Health: The Role of Vaginal Microbiota in Pregnancy
David MacIntyre, PhD

5:30 p.m. – 6:00 p.m.

Mining Big Data to Reveal Biomarkers and Pathophysiology of Preterm Birth: A Skeptic's Guide
William Ackerman, MD

Molecular Biology of Implantation and Recurrent Pregnancy Loss
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: Vikki M. Abrahams, PhD

4:00 p.m. – 4:30 p.m.

Molecular Regulation of Endometrial Plasticity in Implantation and Recurrent Pregnancy Loss
Jan J. Brosens, MD, PhD

4:30 p.m. – 5:00 p.m.

Role of Endogenous Retroviruses in the Establishment and Maintenance of Pregnancy
Neal S. Rote, PhD

5:00 p.m. – 5:30 p.m.

MicroRNA Regulation of Immunotolerance in Early Pregnancy
Sarah A. Robertson, PhD

5:30 p.m. – 6:00 p.m.

Novel Mechanisms of Placental Inflammation in Obstetric Antiphosolipid Syndrome
Vikki M. Abrahams, PhD

Immune Cell Contributions to Endometrial and Cervical Health and Disease
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: Chandrakant Tayade, DVM, PhD

4:00 p.m. – 4:30 p.m.

Modulation of Inflammatory Responses in the Female Reproductive Tract
Charles Wira, PhD

4:30 p.m. – 5:00 p.m.

Immune Basis of Infertility
Bruce Lessey, MD, PhD

5:00 p.m. – 5:30 p.m.

Tissue Resident Uterine Immune Cells
Dorothy K. Sojka, PhD

5:30 p.m. – 6:00 p.m.

Immune Contributions to Initiation of Endometriosis
Chandrakant Tayade, DVM, PhD

Gamete Biology and Gene Editing
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: Kyle Orwig, PhD

4:00 p.m. – 4:30 p.m.

Mitochondrial Replacement Therapy
David L. Keefe, MD

4:30 p.m. – 5:00 p.m.

Target Discovery for Germline Gene Therapy in Male Infertility
Don Conrad, PhD

5:00 p.m. – 5:30 p.m.

Mitochondrial Diseases and Mitochondrial Replacement Therapy
Michio Hirano, MD

5:30 p.m. – 6:00 p.m.

Germline Gene Therapy with Spermatogonial Stem Cells
Kyle Orwig, PhD

Frontiers in Diagnosis, Treatment and Prevention of CMV and Zika in Pregnancy
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: Simcha Yagel, MD

4:00 p.m. – 4:30 p.m.

Ex-Vivo Model of CMV Transmission
Simcha Yagel, MD

4:30 p.m. – 5:00 p.m.

Placental Trophoblasts and Viral Resistance in Recipient Cells
Yoel Sadovsky, MD

5:00 p.m. – 5:30 p.m.

Patterns of CMV and ZIKV Infection in the Uterine-Placenta Interface and Routes of Vertical Transmission
Lenore Pereira, PhD

5:30 p.m. – 6:00 p.m.

Vaccine Development to Control CMV Disease: Immune Manipulation by the Virus
Edward Mocarski, PhD

Linking Early Life Exposures to Later Pathology
Eligible for 2.0 AMA PRA Category 1 Credits ™ / 2.0 Category I College Cognate Credits
Moderator: Dino A. Giussani, PhD, ScD, FRCOG

4:00 p.m. – 4:30 p.m.

Heart Disease Link to Fetal Hypoxia: An Intergenerational Perspective
Dino A. Giussani, PhD, ScD, FRCOG

4:30 p.m. – 5:00 p.m.

Maternal Obesity and Offspring Cardiometabolic Disease: Unravelling the Underlying Mechanisms
Rebecca M. Reynolds, PhD, FRCP, FRCPE

5:00 p.m. – 5:30 p.m.

The Obesity Epidemic: Could it be An Oocyte Issue?
Kelle H. Moley, MD

5:30 p.m. – 6:00 p.m.

Epigenetic Impact of Prenatal Exposure to Adversity
Frances A. Champagne, PhD

6:15 p.m. - 7:45 p.m.

President's Address, Awards, and Wine and Cheese Reception

Floridian D - I

Saturday, March 18

7:00 a.m. - 1:00 p.m.

Registration

Bonnet Creek Foyer

8:00 a.m. - 9:00 a.m.

President's Distinguished Lecture III
Eligible for 1.0 AMA PRA Category 1 Credits ™ / 1.0 Category I College Cognate Credits

Floridian D - I

Maternal-Fetal Conflict and Cooperation in Human Pregnancy
David Haig, PhD
George Putnam Professor of Organismic and Evolutionary Biology
Harvard University

9:00 a.m. - 10:30 a.m.

Poster Session III

Bonnet Creek I - IX

10:30 a.m. - 12:00 p.m.

Concurrent Oral Presentations IV

Various

Developmental Programming II
Moderators:
Sophie Petropoulos, PhD
Jorge P. Figueroa, MD, PhD

Floridian B

10:30 a.m. - 10:45 a.m.

Predictive Modelling of Stress-Related Behavior Through Gene Expression Following Prenatal Glucocorticoid Exposure
Andrea Constantinof, Vasilis Moisiadis, Stephen Matthews

10:45 a.m. - 11:00 a.m.

Treatment with Prenatal Glucocorticoids in Baboons Predisposes Male Offspring (F1) to Obesity in Adulthood
Hilary F. Huber, Anderson H. Kuo, Cun Li, Susan L. Jenkins, Peter W. Nathanielsz

11:00 a.m. - 11:15 a.m.

Maternal Obesity is Associated with Decreased Dopamine Signaling in Juvenile Offspring: A Transgenerational Obesity Cycle
Larissa H. Mattei, Chang Xue, Rachel Zeuner, Emmanuel N. Pothos, Angrea G. Edlow

11:15 a.m. - 11:30 a.m.

Accelerated Ovarian Ageing Induced by Chronic Fetal Hypoxia
C.E. Aiken, J.L. Tarry-Adkins, A.M. Spiroski, A.M. Nuzzo, S.E. Ozanne, D.A. Giussani

11:30 a.m. - 11:45 a.m.

In Utero Bisphenol-A Exposure Leads to Altered Uterine Stromal Cell Migration and Adenomyosis
Myles H. Alderman III, Demetra Hufnagel, Hugh S. Taylor

11:45 a.m. - 12:00 p.m.

Nutrient Sensor-Epigenome Regulation of Apidogenesis Programs Obesity in Offspring of Obese Mothers
Mina Desai, Guang Han, Kavita Narwani, Elaheh Mossayebi, Marie H. Beall, Michael G. Ross

Fetus II
Moderators:
Peta L. Grigsby, PhD
Dean A. Myers, PhD

Bonnet Creek X

10:30 a.m. - 10:45 a.m.

Cardiac Assessment by 4D Echocardiography of Fetal Guinea Pigs
Shifa Turan, Graham W. Aberdeen, Loren P. Thompson

10:45 a.m. - 11:00 a.m.

Neuronal Exosome Synaptopodin: An Early Predictor of Therapeutic Response to Controlled Hypothermia
Laura Goetzl, Diana Martirosyan, Nune Darbinian, Nana Merabova, Keri Fugarolas, Ogechukwu Menkiti

11:00 a.m. - 11:15 a.m.

Volumetric and Vascular MRI Placental Changes with Exposure to Intrauterine Inflammation: Biomarker of Fetal Brain Injury
Jun Lei, Dan Wu, Solange Eloundou, Wael Alshehri, Jiangyang Zhang, Irina Burd

11:15 a.m. - 11:30 a.m.

Chronic Hypoxia Alters Fetal Cerebrovascular Responses to Endothelin-1
Jinjutha Silpanisong, Dahlim Kim, James M. Williams, Olayemi O. Adeoye, William J. Pearce

11:30 a.m. - 11:45 a.m.

Role of Uric Acid and GLUT9 in Pregnancy on Neonatal Development
Benjamin P. Lüscher, Daniel V. Surbek, Camilla Marini, Marc U. Baumann

11:45 a.m. - 12:00 p.m.

Cardiac miRNA Expression in the Fetus and Six Month Old Sheep in Response to Myocardial Infarction
Mitchell Lock, Jia Yin Soo, Jack Darby, Doug Brooks, Enzo Porrello, Ross Tellam, Janna Morrison

Parturition III
Moderators:
Jennifer Herington, PhD
Mala Mahendroo, PhD

Bonnet Creek XII

10:30 a.m. - 10:45 a.m.

Effect of Amnion Derived Exosomes on Feto-Maternal Gestational Cells: Novel Signalers in the Labor Cascade?
Emily E. Hadley, Samantha Sheller, Rheanna Urrabaz-Garza, Talar Kechichian, George Saade, Sam Mesiano, Robert Taylor, Ramkumar Menon

10:45 a.m. - 11:00 a.m.

Collagen Type 1 Gels Augment Healing of Ruptured Amnion in Mouse PROM
Haruta Mogami, Annvarapu H. Kishore, R. Ann Word

11:00 a.m. - 11:15 a.m.

Mechanisms Underlying the Effects of Retosiban/GSK221149A on the Response to Mechanical Stretch in Human Myometrial Explants
Irving L.M.H. Aye, Alex Moraitis, D. Stephen Charnock-Jones, Gordon C.S. Smith

11:15 a.m. - 11:30 a.m.

Characterization of Peptides Against Neuromedin U Receptor 2 in Preterm Labor
Amarilys Boudreault, Christiane Quiniou, Xin Hou, Mathieu Nadeau-Vallée, Sylvain Chemtob

11:30 a.m. - 11:45 a.m.

Adiponectin Receptor Activation Mediates Myometrial Tocolysis: A Mechanism for Obesity Related Preterm Birth
Vibhuti Vyas, Nathan Anderson, Rachael Bok, Theresa Powell, Thomas Jansson, Kenneth J. Hurt

11:45 a.m. - 12:00 p.m.

Functional Pharmacology Coupled with Metabolomics Reveals Novel Pathways of Chlorophyll Compounds on Myometrial Activity
Enitome E. Bafor, Edward G. Rowan, RuAngelie Edrada-Ebel

Placenta II
Moderators:
Vicki L. Clifton, PhD
Susanne Lager, PhD

Bonnet Creek XI

10:30 a.m. - 10:45 a.m.

Inhibition of the Auto-Inflammation Suppressor Protein ISG15 Triggers Preeclampsia by Blocking Trophoblast Migration and Invasion
Nihan Semerci, Ozlem Guzeloglu-Kayisli, Sefa Arlier, Kellie Larsen, Chinedu Nwabuobi, Frederick Schatz, Antony Obido, Charles Lockwood, Umit Kayisli

10:45 a.m. - 11:00 a.m.

Rosiglitazone Reduces Endotoxin Mediated Effects on Inflammation and Trophoblast Differentiation in First Trimester Human Placenta
Leena T. Kadam, Brian Kilburn, Aalem Singh, Hamid Reza Kohan-Ghadr, Sascha T. Drewlo

11:00 a.m. - 11:15 a.m.

SDF2 is a Novel Component of ER Stress-Induced Apoptosis Pathway in Trophoblast Cells via PERK-eIF2 Alpha-ATF4 Branch
Aline R. Lorenzon-Ojea, Clarissa R. Rocha, Estela Bevilacqua

11:15 a.m. - 11:30 a.m.

Human Placental Endothelial Cells are Capable of Recovering from Failed Angiogenesis Secondary to Impaired Wnt Signaling
Toluwalope O. Junaid, Paul Brownbill, Edward D. Johnstone, John D. Aplin

11:30 a.m. - 11:45 a.m.

mTOR Inhibition Down-Regulates Mitochondrial Function in Primary Human Trophoblast Cells and is Associated with Decreased Expression of Electron Transport Chain Complexes in IUGR Placentas
F.J. Rosario, M.B. Gupta, L. Cox, T.L. Powell, T. Jansson

11:45 a.m. - 12:00 p.m.

Sexual Dimorphism in the Regulation of Placental Metabolism and Fetal Growth by miR-210
Yu Wang, Matthew S. Bucher, Bailey L. Simon, Alina Maloyan, Leslie Myatt

Reproductive Endocrinology and Infertility II
Moderators:
Alan DeCherney, MD
Reshef Tal, MD, PhD

Floridian A

10:30 a.m. - 10:45 a.m.

Disruption of Mitochondrial Proteostasis Results in Impaired Mitochondrial Dynamics and Female Infertility
Tianren Wang, Tim Sanchez, Daniel Neddleman, Denny Sakkas, Tamas Horvath, Emre Seli

10:45 a.m. - 11:00 a.m.

Creating a Hormonally Active 3-Dimensional Ovarian Follicle via a Microfluidic System
Mae W. Healy, Shelley N. Dolitsky, Meera Raghaven, Alex Tillman, Maria Villancio-Wolter, Nicole Y Morgan, Alan H. DeCherney, Erin F. Wolff, Solji Park

11:15 a.m. - 11:30 a.m.

Discovery-Based Proteomic Profiling of Tubal Fluid in Hydrosalpinx Reveals Candidate Biomarkers
Morgan E. Lindsay, Elizabeth H. Yohannes, Avedis A. Kazanjian, Ryan J. Heitmann, Richard O. Burney

11:30 a.m. - 11:45 a.m.

Oocyte/Embryo Utilization Rates and Disposition Decisions in Fertility Preservation Patients
Molly B. Moravek, Rafael Confino, Angela K. Lawson, Kristin N. Smith, Susan C. Klock, Mary Ellen Pavone

11:45 a.m. - 12:00 p.m.

Utility of PGS to Determine the Need for Repeat Embryo Cryopreservation Cycles and Improve Fertility Preservation Success in Cancer Patients
Ozgur Kan, Kutluk Oktay

Stem Cells
Moderators:
Panicos Shangaris, MD, BAO, MSc
Hugh S. Taylor, MD

Floridian C

10:30 a.m. - 10:45 a.m.

Cytoskeletal Tension and YAP Regulation Modulate Mechanosensation in Oogonial Stem Cells
Julie A. MacDonald, Dori C. Woods, Jonathan L. Tilly

10:45 a.m. - 11:00 a.m.

Identification of Novel Epigenetic Reprogrammed Genes in Myometrial Stem Cells Developmentally Exposed to Endocrine Disrupting Chemicals
Qiwei Yang, Lindsey S. Trevino, Aymara Mas, Michael P. Diamond, Cheryl Lyn Walker, Ayman Al-Hendy

11:00 a.m. - 11:15 a.m.

Maternal Mesenchymal Stem Cell Administration Alleviates Intrauterine Inflammation-Induced Perinatal Brain Injury Through CD8*T Cell Suppression in Placenta
Li Xie, Honxi Zhao, Jun Lei, Lu Zhong, Hattan Arif, Michael McLane, Irina Burd

11:15 a.m. - 11:30 a.m.

Trophoblast Spheroid Model Derived from hiPSCs to Study Trophoblast Functions Under Pathological-Like Conditions
Mehboob Ali, Mark Hester, Lisa Zhao, Irian A. Buhimschi

11:30 a.m. - 11:45 a.m.

High Throughput Screen (HTS) Using Viable Fluorescent ESC Reporters of Stressed-Forced Differentiation of the First Lineage
Erica D. Louden, Elizabeth E. Puscheck, Quanwen Li, Kang Chen, Daniel A. Rappolee

11:45 a.m. - 12:00 p.m.

Endothelial Progenitor Cells Contribute to Vasculogenesis of the Pregnant Mouse Uterus
Reshef Tal, Dong Dirong, Shafiq Shaikh, Ramanaiah, Maimillapalli, Hugh S. Taylor

12:15 p.m. - 1:45 p.m.

Hot Topics & Awards Ceremony
Moderators: Emre Seli, MD
Marilyn Cipolla, PhD

Floridian D - I

2:00 p.m. - 4:00 p.m.

SRI Council Meeting

Manatee

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